skip navigation links
National Cancer Institute
Enterprise Vocabulary Services
Box
NCIm Version: 201808 (Browser Version 2.9, using LexEVS 6.5.1)
SearchBox Top
SearchBox Bottom
Restless Legs Syndrome (CUI C0035258) Suggest changes to this concept
Add to Cart

Terms & Properties

Concept Unique Identifier (CUI): C0035258

NCI Thesaurus Code: C84501  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: A condition that occurs while resting or lying in bed; it is characterized by an irresistible urgency to move the legs to obtain relief from a strange and uncomfortable sensation in the legs.

MSH Definition: A disorder characterized by aching or burning sensations in the lower and rarely the upper extremities that occur prior to sleep or may awaken the patient from sleep.

HPO Definition: A feeling of uneasiness and restlessness in the legs after going to bed (sometimes causing insomnia). [HPO:probinson]

MEDLINEPLUS Definition: 

Restless legs syndrome (RLS) causes a powerful urge to move your legs. Your legs become uncomfortable when you are lying down or sitting. Some people describe it as a creeping, crawling, tingling, or burning sensation. Moving makes your legs feel better, but not for long. RLS can make it hard to fall asleep and stay asleep.

In most cases, there is no known cause for RLS. In other cases, RLS is caused by a disease or condition, such as anemia or pregnancy. Some medicines can also cause temporary RLS. Caffeine, tobacco, and alcohol may make symptoms worse.

Lifestyle changes, such as regular sleep habits, relaxation techniques, and moderate exercise during the day can help. If those don't work, medicines may reduce the symptoms of RLS.

Most people with RLS also have a condition called periodic limb movement disorder (PLMD). PLMD is a condition in which a person's legs twitch or jerk uncontrollably, usually during sleep. PLMD and RLS can also affect the arms.

NIH: National Heart, Lung, and Blood Institute

NCI-GLOSS Definition: A condition in which a person has a strong urge to move his or her legs in order to stop uncomfortable sensations. These include burning, itching, creeping, tugging, crawling, or pain. These feelings usually happen when a person is lying or sitting down, and are worse at night. They can also occur in other parts of the body.

NICHD Definition: Uncomfortable or painful sensation associated with an irresistible urge to move the limbs, usually triggered by relaxation or lying down.

CSP Definition: neurological disorder characterized by unpleasant sensations of the legs and an urge to move them for relief; usually occurs during or just prior to sleep, causing difficulty falling asleep or staying asleep.

Synonyms & Abbreviations: (see Synonym Details)
Disease, Willis Ekbom
Disease, Willis-Ekbom
ekbom syndrome
LEGS RESTLESS
RESTLESS LEG SYNDROME
Restless legs (disorder)
Restless legs syndrome (RLS)
Restless Legs Syndrome [Disease/Finding]
restless legs syndrome
RESTLESS LEGS
RLS
SYNDROME RESTLESS LEGS
Syndrome, Restless Leg
Syndrome, Willis Ekbom
Syndrome, Willis-Ekbom
Syndrome, Wittmaack Ekbom
Syndrome, Wittmaack-Ekbom
Willis Ekbom Disease
Willis Ekbom Syndrome
Willis-Ekbom disease
Willis-Ekbom Syndrome
Wittmaack Ekbom Syndrome
Wittmaack-Ekbom syndrome

External Source Codes: 
NCI Thesaurus Code C84501 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN note entry terms containing "Ekbom": do not confuse with entry terms for DELUSIONAL PARASITOSIS which also contain "Ekbom" MSH
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
Contributing_Source MedDRA NCI
Contributing_Source NICHD NCI
CTV3ID F13z2 SNOMEDCT_US
DATE_CREATED 07/01/1999 MEDLINEPLUS
DATE_CREATED 2013-11-23T07:42:59Z HPO
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 5006-0032 CSP
DX 19730101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
HN 2000(1973) MSH
HPO_COMMENT Restless legs syndrome is a disorder characterized by aching or burning sensations in the legs that occur prior to sleep or may awaken the affected persons. Complying with an irresistible urge to move the affected limbs brings temporary relief. Sleep may become disrupted, resulting in excessive daytime hypersomnolence. HPO
IPX G25.8 ICPC
MDA 19990101 MSH
MESH_DEFINITION A disorder characterized by aching or burning sensations in the lower and rarely the upper extremities that occur prior to sleep or may awaken the patient from sleep. NDFRT
MESH_DUI D012148 NDFRT
MESH_NAME Restless Legs Syndrome NDFRT
MESH_UI M0018926 NDFRT
MMR 20130708 MSH
MN C10.803 MSH
MN C10.886.425.800.700 MSH
MN C10.886.659.634 MSH
MN F03.870.400.800.700 MSH
MN F03.870.664.634 MSH
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/restlesslegs.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/restlesslegs.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Institute of Neurological Disorders and Stroke http://www.ninds.nih.gov/ MEDLINEPLUS
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Restless Leg Syndrome NCI
NUI N0000002605 NDFRT
ORDER_NO 05865 ICD10CM
PM 2000; see Restless Legs 1973-1999 MSH
PRIMARY_PATH 10058920$10040021$10029305$10029205$Restless legs syndrome$Sensory abnormalities NEC$Neurological disorders NEC$Nervous system disorders MDR
PRIMARY_SOC 10029205 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RXAUI 3231768 RXNORM
RXAUI 3231769 RXNORM
RXAUI 3231770 RXNORM
RXAUI 5932169 RXNORM
RXAUI 5932448 RXNORM
RXAUI 5932449 RXNORM
RXAUI 5932450 RXNORM
RXAUI 5932451 RXNORM
RXAUI 5932454 RXNORM
RXAUI 5932455 RXNORM
RXCUI 1025449 RXNORM
SNOMED_CID 32914008 NDFRT
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS G25.8 | POSSIBLE REQUIREMENT FOR AN EXTERNAL CAUSE CODE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~G25.8 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS G25.81 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~G25.81 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~F13z2 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T036177 MSH
TERMUI T365808 MSH
TERMUI T829757 MSH
TERMUI T829758 MSH
TERMUI T829759 MSH
TERMUI T829760 MSH
TERMUI T829761 MSH
TERMUI T829762 MSH
TERMUI T830589 MSH
TH NLM (1973) MSH
TH NLM (2000) MSH
TH NLM (2014) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0035258

Mainbox Bottom