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Quercetin (CUI C0034392) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0034392

NCI Thesaurus Code: C792  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Pharmacologic Substance

NCIt Definition: A polyphenolic flavonoid with potential chemopreventive activity. Quercetin, ubiquitous in plant food sources and a major bioflavonoid in the human diet, may produce antiproliferative effects resulting from the modulation of either EGFR or estrogen-receptor mediated signal transduction pathways. Although the mechanism of action of action is not fully known, the following effects have been described with this agent in vitro: decreased expression of mutant p53 protein and p21-ras oncogene, induction of cell cycle arrest at the G1 phase and inhibition of heat shock protein synthesis. This compound also demonstrates synergy and reversal of the multidrug resistance phenotype, when combined with chemotherapeutic drugs, in vitro. Quercetin also produces anti-inflammatory and anti-allergy effects mediated through the inhibition of the lipoxygenase and cyclooxygenase pathways, thereby preventing the production of pro-inflammatory mediators.

PDQ Definition: A polyphenolic flavonoid with potential chemopreventive activity. Quercetin, ubiquitous in plant food sources and a major bioflavonoid in the human diet, may produce antiproliferative effects resulting from the modulation of either EGFR or estrogen-receptor mediated signal transduction pathways. Although the mechanism of action of action is not fully known, the following effects have been described with this agent in vitro: decreased expression of mutant p53 protein and p21-ras oncogene, induction of cell cycle arrest at the G1 phase and inhibition of heat shock protein synthesis. This compound also demonstrates synergy and reversal of the multidrug resistance phenotype, when combined with chemotherapeutic drugs, in vitro. Quercetin also produces anti-inflammatory and anti-allergy effects mediated through the inhibition of the lipoxygenase and cyclooxygenase pathways, thereby preventing the production of pro-inflammatory mediators. Check for active clinical trials using this agent. (NCI Thesaurus)

CRCH Definition: A kaempferol with a hydroxyl group at C-3'.

CSP Definition: antioxidant flavonol widely distributed in plants.

MSH Definition: A flavonol widely distributed in plants. It is an antioxidant, like many other phenolic heterocyclic compounds. Glycosylated forms include RUTIN and quercetrin.

Synonyms & Abbreviations: (see Synonym Details)
2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one
2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromen-4-one
3,3',4',5,7-Pentahydroxyflavone
4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-
C.I. Natural Yellow 10
Dikvertin
Quercetin (substance)
Quercetin [Chemical/Ingredient]
Quercetin preparation (product)
Quercetin preparation
quercetin

External Source Codes: 
NCI Thesaurus Code C792 (see NCI Thesaurus info)
CAS Registry Number 117-39-5 (see NLM ChemIDplus info)
FDA UNII Code 9IKM0I5T1E
NSC Code 9219 (see NCI DTP info)
PDQ Closed Trial Search ID 43114
PDQ Open Trial Search ID 43114 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BI BL CF CH CL CS CT EC GE HI IM IP ME PD PH PK PO RE SD SE ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:16243 NCI
Chemical_Formula C15H10O7 NCI
Contributing_Source CRCH NCI
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID XU6fE SNOMEDCT_US
CTV3ID XUFk1 SNOMEDCT_US
DATE_LAST_MODIFIED 2012-10-24 PDQ
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 1154-1145 CSP
DX 19910101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
FDA_UNII_CODE 9IKM0I5T1E NDFRT
HN 1991(1975); MSH
LEVEL Ingredient NDFRT
MDA 19990101 MSH
MESH_DEFINITION A flavonol widely distributed in plants. It is an antioxidant, like many other phenolic heterocyclic compounds. Glycosylated forms include RUTIN and quercetrin. NDFRT
MESH_DUI D011794 NDFRT
MESH_NAME Quercetin NDFRT
MESH_UI M0018327 NDFRT
MMR 20160531 MSH
MN D03.383.663.283.266.450.284.777 MSH
MN D03.633.100.150.266.450.284.777 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NCI_THESAURUS_CODE C792 PDQ
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000167022 NDFRT
NUI N0000182642 NDFRT
ORIG_STY Drug/agent PDQ
PA D000975 MSH
PID 7510 PDQ
PM 1991; 3,3',4',5,7-PENTAHYDROXYFLAVONE was indexed under FLAVINOIDS 1999-2013, see FLAVONES 1975-1990, see BIOFLAVONOIDS 1963-1974 MSH
RN 9IKM0I5T1E MSH
RR 117-39-5 (Quercetin) MSH
RXAUI 290381 RXNORM
RXAUI 3093794 RXNORM
RXAUI 3227052 RXNORM
RXAUI 3227054 RXNORM
RXAUI 3632464 RXNORM
RXAUI 3717899 RXNORM
RXAUI 3720414 RXNORM
RXAUI 3720415 RXNORM
RXAUI 4618403 RXNORM
RXAUI 5930041 RXNORM
RXAUI 5930734 RXNORM
RXCUI 9060 RXNORM
SPL_SET_ID 05f6cca2-5f5f-4538-8def-0c459b5ca4c0 MTHSPL
SPL_SET_ID 06b3137f-15cb-4d30-8741-12f6231e8402 MTHSPL
SPL_SET_ID 1430eca0-ca85-4852-a0c0-032a96b845e2 MTHSPL
SPL_SET_ID 179dc9f7-10b3-4a41-8daf-7846730b7865 MTHSPL
SPL_SET_ID 1d0de662-ab95-4534-9889-d83abde05608 MTHSPL
SPL_SET_ID 24dc942b-dce3-4d4b-ac1d-15723e9404b3 MTHSPL
SPL_SET_ID 2b65a555-2bb3-4caf-b366-0afe7ed4cf2c MTHSPL
SPL_SET_ID 2ccbffbd-4e87-48ad-ae8e-dcdaf04972b4 MTHSPL
SPL_SET_ID 2da03883-f86f-4f5b-9537-ed4201e2bc73 MTHSPL
SPL_SET_ID 2f5b946f-3751-4bcc-ace9-eb5041dd189e MTHSPL
SPL_SET_ID 30d7c66e-9a92-4e96-9ec9-20bbdd863a2a MTHSPL
SPL_SET_ID 33c0a5ad-3a7a-44c3-862d-288f4a7bc5c4 MTHSPL
SPL_SET_ID 3560f11d-e5fc-4b2f-bb87-6054060414a1 MTHSPL
SPL_SET_ID 3615fdf9-bdc5-44ad-a9f3-cbd0ea87c4a5 MTHSPL
SPL_SET_ID 49f31fe2-bb1f-4596-b748-86ae0567c261 MTHSPL
SPL_SET_ID 5ac18b08-021f-4091-9b10-5dd5c5c4955d MTHSPL
SPL_SET_ID 5c8f36b2-aec3-442a-bc13-d454a0de252b MTHSPL
SPL_SET_ID 60ddc558-882c-454c-aa61-bf8bc7270f70 MTHSPL
SPL_SET_ID 619a3a3f-039e-437f-b734-2f6dd280c029 MTHSPL
SPL_SET_ID 67731723-9078-4eff-bbf2-582d07982edc MTHSPL
SPL_SET_ID 6d196573-3d99-418e-a25c-4d84ba711eab MTHSPL
SPL_SET_ID 6f494d81-e439-4dbc-aef2-e3ce9e691b1c MTHSPL
SPL_SET_ID 714bba7d-daf2-4f90-bf18-9129e2db5d17 MTHSPL
SPL_SET_ID 74d757cd-6eb0-4a14-8b32-4ddd3619d0ca MTHSPL
SPL_SET_ID 7c76bce0-5f91-4c32-a1d9-b2cd607418c2 MTHSPL
SPL_SET_ID 7ea0c9a4-a616-4d13-a7bf-c09b4cb1ab60 MTHSPL
SPL_SET_ID 87dec202-711c-4270-a176-306cf6365558 MTHSPL
SPL_SET_ID 9433f1c1-3c3f-45f2-81e1-1aca241d5b76 MTHSPL
SPL_SET_ID 99b7dad2-bf6d-4d0f-923b-6eef4c56bc41 MTHSPL
SPL_SET_ID a06106dd-4ca6-4c7f-99b3-b8e464bf59bb MTHSPL
SPL_SET_ID a3c6cfa5-c6f6-489e-9270-7c4dacb5fcb0 MTHSPL
SPL_SET_ID a5786c97-1339-4ec9-8730-b039aaa32650 MTHSPL
SPL_SET_ID b0b52963-0ce7-47bd-b06a-1fa8da17e761 MTHSPL
SPL_SET_ID b2b15c98-8fc4-40b8-af18-0e6b0c176781 MTHSPL
SPL_SET_ID b63fbb3b-662d-4752-8ea5-d05ed96b648f MTHSPL
SPL_SET_ID b7172039-9cca-4a43-a06e-535027879967 MTHSPL
SPL_SET_ID be0e5c01-7e28-4de4-abce-e40ae27bdb41 MTHSPL
SPL_SET_ID c2d4d260-9d53-4314-a9e1-a710cd00a27e MTHSPL
SPL_SET_ID c4a3b80a-26d8-430c-9b7c-2e6de0fb2e7b MTHSPL
SPL_SET_ID c54d391e-33d1-4af8-a510-321a544c50c4 MTHSPL
SPL_SET_ID c8c3e50f-023e-4f89-84a7-ad5678381649 MTHSPL
SPL_SET_ID c9dbfdfa-287a-465c-b8ac-03b1dead1d54 MTHSPL
SPL_SET_ID d00794b2-183c-4adb-b499-c4b9d30704e5 MTHSPL
SPL_SET_ID d2115d34-5ec2-475d-8c47-7ef22a09fd27 MTHSPL
SPL_SET_ID d658fdc7-9dac-47bf-8e83-1433a29a6cf6 MTHSPL
SPL_SET_ID e3830e3f-fa8f-4f44-91f1-69ecfc6ae71f MTHSPL
SPL_SET_ID e96ed884-239a-4676-aa3c-a472d8e23a61 MTHSPL
SPL_SET_ID f13a92ec-bb94-4ebd-acaa-b9ad14d67cac MTHSPL
SPL_SET_ID f474e0d7-5287-491a-8759-23396af43119 MTHSPL
SPL_SET_ID f8bd067b-49f3-4c06-82a3-7189cd3f573b MTHSPL
SPL_SET_ID fa8b2dd2-fe78-4b32-883d-8e1401b42822 MTHSPL
SPL_SET_ID fd40af4a-92c1-4d38-931a-4c92a8184c3e MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~XU6fE SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUFk1 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
TERMUI T034837 MSH
TERMUI T837058 MSH
TERMUI T837059 MSH
TH FDA SRS (2014) MSH
TH NLM (1975) MSH
TH NLM (2014) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
Unit mg NCI
VANDF_RECORD 50.416^4741^Active/Master NDFRT
VANDF_RECORD 50.6^4624^Active/Master NDFRT
VUID 4030654 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0034392

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