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pyridoxine (CUI C0034272) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0034272

NCI Thesaurus Code: C62619  (see NCI Thesaurus info)

Semantic Type: Vitamin

Semantic Type: Pharmacologic Substance

NCI-GLOSS Definition: A nutrient in the vitamin B complex that the body needs in small amounts to function and stay healthy. Pyridoxine helps keep nerves and skin healthy, fight infections, keep blood sugar levels normal, produce red blood cells, and some enzymes work properly. Pyridoxine is a group of related compounds (pyridoxine, pyridoxal, and pyridoxamine) found in cereals, beans, peas, nuts, meat, poultry, fish, eggs, and bananas. It is water-soluble (can dissolve in water). Not enough pyridoxine can cause mouth and tongue sores and nervous disorders. Pyridoxine is being studied in the prevention of hand-foot syndrome (a disorder caused by certain anticancer drugs and marked by pain, swelling, numbness, tingling, or redness of the hands or feet).

MSH Definition: The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).

Synonyms & Abbreviations: (see Synonym Details)
2-Methyl-3-hydroxy-4,5-dihydroxymethylpyridine
3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-
3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine
3-Hydroxy-4,5-dimethylol-alpha-picoline
5-Hydroxy-6-methyl-3,4-pyridinedimethanol
[VT104] PYRIDOXINE
Pyridoxine (substance)
Pyridoxine [Chemical/Ingredient]
Pyridoxine Drug Class
Pyridoxine preparation (product)
Pyridoxine preparation
pyridoxine
Pyridoxin
pyridoxol

External Source Codes: 
NCI Thesaurus Code C62619 (see NCI Thesaurus info)
CAS Registry Number 65-23-6 (see NLM ChemIDplus info)
FDA UNII Code KV2JZ1BI6Z

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN deficiency: coordinate PYRIDOXINE /defic (IM) with VITAMIN B 6 DEFICIENCY (IM) MSH
AQL AA AD AE AG AI AN BI BL CF CH CL CS CT DF EC GE HI IM IP ME PD PH PK PO RE SD SE ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:16709 NCI
Chemical_Formula C8H11NO3 NCI
Contributing_Source FDA NCI
CTV3ID x01PP SNOMEDCT_US
CTV3ID XUgRd SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 3147-5673 CSP
DRUG_CLASS_TYPE 2 VANDF
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20080731 SNOMEDCT_US
FDA_UNII_CODE KV2JZ1BI6Z DRUGBANK
FDA_UNII_CODE KV2JZ1BI6Z NDFRT
HN ETOH descriptor 1995. AOD
LEVEL Ingredient NDFRT
LEVEL VA Class NDFRT
MDA 19990101 MSH
MESH_DEFINITION The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990). NDFRT
MESH_DUI D011736 NDFRT
MESH_NAME Pyridoxine NDFRT
MESH_UI M0018247 NDFRT
MMR 20160531 MSH
MN D03.383.725.676.925.875 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006060 NDFRT
NUI N0000029452 NDFRT
NUI N0000148007 NDFRT
PA D014803 MSH
PARENT_CLASS 427 VANDF
RN KV2JZ1BI6Z MSH
RR 58-56-0 (hydrochloride) MSH
RR 65-23-6 MSH
RR 68Y4CF58BV MSH
RXAUI 2074094 RXNORM
RXAUI 2629071 RXNORM
RXAUI 2760584 RXNORM
RXAUI 3093125 RXNORM
RXAUI 3217260 RXNORM
RXAUI 3217261 RXNORM
RXAUI 3217262 RXNORM
RXAUI 3226510 RXNORM
RXAUI 3226511 RXNORM
RXAUI 3226516 RXNORM
RXAUI 3226520 RXNORM
RXAUI 3257951 RXNORM
RXAUI 3280018 RXNORM
RXAUI 3280073 RXNORM
RXAUI 4248717 RXNORM
RXCUI 1551665 RXNORM
RXCUI 684879 RXNORM
SID APRD00204 DRUGBANK
SID NUTR00002 DRUGBANK
SNOMEDID C-A4440 SNOMEDCT_US
SNOMEDID F-BB59E SNOMEDCT_US
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SPL_SET_ID f5c9e7ee-01a9-4b5c-a08b-b64570ba18f0 MTHSPL
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SPL_SET_ID f8489a5b-72d1-4bb3-b686-8984c779dd66 MTHSPL
SPL_SET_ID f9de62af-4b3d-45a0-8db1-c2e0e52f2ace MTHSPL
SPL_SET_ID fa02b240-62cd-4042-839e-a04d2f41d6b7 MTHSPL
SPL_SET_ID fa8470fb-6e36-4c5a-8b44-cc9965638bb5 MTHSPL
SPL_SET_ID fad8432f-caf4-4e0b-91ec-12995652bd68 MTHSPL
SPL_SET_ID fb8d7ace-df0c-49f6-8d91-fa2d76e596d5 MTHSPL
SPL_SET_ID fb8eb411-0bf2-4ba8-ae9a-b08f113d54d7 MTHSPL
SPL_SET_ID fc729ca5-3846-48fd-8d8c-d2b6a7563741 MTHSPL
SPL_SET_ID fe0a737e-4f28-40d8-b4a7-090edf86a823 MTHSPL
SPL_SET_ID ff83f5d0-7dec-4089-aafe-77e486d9d335 MTHSPL
SPL_SET_ID ffb770b4-8b6d-445c-9faa-8a61efd7d6b0 MTHSPL
SPL_SET_ID ffc79b35-c32a-4a36-a8b4-20e2a816c9de MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~x01PP SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUgRd SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~C-A4440 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~F-BB59E SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T034694 MSH
TERMUI T034695 MSH
TERMUI T429907 MSH
TH FDA SRS (2015) MSH
TH INN (19XX) MSH
TH NLM (1966) MSH
TH NLM (2002) MSH
TH UNK (19XX) MSH
TH USAN (1999) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VAC VT104 NDFRT
VAC VT104 VANDF
VANDF_RECORD 50.416^2547^Active/Master NDFRT
VANDF_RECORD 50.605^422^Active/Master NDFRT
VANDF_RECORD 50.6^44^Active/Master NDFRT
VUID 4019922 NDFRT
VUID 4021899 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0034272

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