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Pyridoxal Phosphate (CUI C0034266) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0034266

NCI Thesaurus Code: C81627  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Vitamin

Semantic Type: Pharmacologic Substance

NCIt Definition: The active form of vitamin B6 and a coenzyme for many pyridoxal phosphate (PLP)-dependent enzymes. PLP is involved in numerous enzymatic transamination, decarboxylation and deamination reactions; it is necessary for the synthesis of amino acids and amino acid metabolites, and for the synthesis and/or catabolism of certain neurotransmitters, including the conversion of glutamate into gamma-aminobutyric acid (GABA) and levodopa into dopamine. PLP can be used as a dietary supplement in cases of vitamin B6 deficiency. Reduced levels of PLP in the brain can cause neurological dysfunction.

MSH Definition: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).

Synonyms & Abbreviations: (see Synonym Details)
4-Pyridinecarboxaldehyde, 3-hydroxy-2-methyl-5-((phosphonooxy)methyl)-
Phosphate, Pyridoxal
Pyridoxal 5 Phosphate
PYRIDOXAL 5'-PHOSPHATE
Pyridoxal 5-Phosphate
Pyridoxal phosphate (product)
Pyridoxal phosphate (substance)
Pyridoxal Phosphate [Chemical/Ingredient]
pyridoxal phosphate
Pyridoxal P
Pyridoxal-P

External Source Codes: 
NCI Thesaurus Code C81627 (see NCI Thesaurus info)
CAS Registry Number 41468-25-1 (see NLM ChemIDplus info)
FDA UNII Code 5V5IOJ8338

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN deficiency: coordinate PYRIDOXAL PHOSPHATE /defic (IM) with VITAMIN B 6 DEFICIENCY (IM) MSH
AQL AA AD AE AG AI AN BI BL CF CH CL CS CT DF EC GE HI IM IP ME PD PH PK PO RE SD SE ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Chemical_Formula C8H10NO6P.H2O NCI
Contributing_Source FDA NCI
CTV3ID X80RW SNOMEDCT_US
CTV3ID XUebx SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 3147-5307 CSP
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20070131 SNOMEDCT_US
FDA_UNII_CODE F06SGE49M6 NDFRT
LEVEL Ingredient NDFRT
MDA 19990101 MSH
MESH_DEFINITION This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE). NDFRT
MESH_DUI D011732 NDFRT
MESH_NAME Pyridoxal Phosphate NDFRT
MESH_UI M0018242 NDFRT
MMR 20160531 MSH
MN D03.383.725.676.925.500.500 MSH
MN D08.211.740 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000007581 NDFRT
NUI N0000023490 NDFRT
PA D014803 MSH
RN 5V5IOJ8338 MSH
RR 54-47-7 (Pyridoxal Phosphate) MSH
RXAUI 2602644 RXNORM
RXAUI 288959 RXNORM
RXAUI 3093692 RXNORM
RXAUI 3217258 RXNORM
RXAUI 3217259 RXNORM
RXAUI 3226492 RXNORM
RXAUI 3226496 RXNORM
RXAUI 3226497 RXNORM
RXAUI 3226500 RXNORM
RXAUI 3862268 RXNORM
RXAUI 4651901 RXNORM
RXCUI 9004 RXNORM
SPL_SET_ID 2fac1a04-070e-4516-86f7-441302e8d70b MTHSPL
SPL_SET_ID 33f32537-b148-48f3-a732-1f7c2f092f00 MTHSPL
SPL_SET_ID 88ecef82-6c3c-419b-9138-921fea04913a MTHSPL
SPL_SET_ID a82f674f-a17c-4a21-b7c1-8ccb0fc430d3 MTHSPL
SPL_SET_ID d271868a-9461-4ca4-97ee-4dab4af902d0 MTHSPL
SPL_SET_ID e83b2dd3-a9a0-40bc-ade4-6cd4db433b06 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~X80RW SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUebx SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T034682 MSH
TERMUI T034683 MSH
TERMUI T034684 MSH
TH FDA SRS (2014) MSH
TH NLM (1966) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^4246^Active/Master NDFRT
VUID 4024929 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0034266

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