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Purpura, Thrombotic Thrombocytopenic (CUI C0034155) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0034155

NCI Thesaurus Code: C78797  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: A coagulation disorder characterized by extensive formation of thrombi in small blood vessels throughout the body due to low levels of ADAMTS13 protein, and resulting in consumption of circulating platelets, which is characterized by thrombocytopenia, anemia, neurologic changes, and sometimes fever and renal dysfunction.

CTCAE Definition: A disorder characterized by the presence of microangiopathic hemolytic anemia, thrombocytopenic purpura, fever, renal abnormalities and neurological abnormalities such as seizures, hemiplegia, and visual disturbances. It is an acute or subacute condition.

NICHD Definition: A coagulation disorder characterized by extensive formation of thrombi in small blood vessels throughout the body due to low levels of ADAMTS13 protein, and resulting in consumption of circulating platelets, which is characterized by thrombocytopenia, anemia, neurologic changes, and sometimes fever and renal dysfunction.

MSH Definition: An acquired, congenital, or familial disorder caused by PLATELET AGGREGATION with THROMBOSIS in terminal arterioles and capillaries. Clinical features include THROMBOCYTOPENIA; HEMOLYTIC ANEMIA; AZOTEMIA; FEVER; and thrombotic microangiopathy. The classical form also includes neurological symptoms and end-organ damage, such as RENAL FAILURE.

Synonyms & Abbreviations: (see Synonym Details)
Disease, Moschcowitz
Disease, Moschkowitz
Moschcowitz Disease
MOSCHCOWITZ SYNDROME
Moschcowitz's syndrome
Moschkowitz Disease
MOSCHKOWITZ DIS
Moschowitz Disease
Moschowitz syndrome
Moschowitz's syndrome
Purpura thrombopaenic thrombotic
PURPURA THROMBOPENIC THROMBOTIC
PURPURA, THROMBOCYTOPENIC, THROMBOTIC
PURPURA, THROMBOHEMOLYTIC
Purpura, Thrombotic Thrombocytopenic [Disease/Finding]
Purpura, thrombotic thrombocytopenic
Purpura, Thrombotic Thrombopenic
Thrombocytopenic purpura, thrombotic
Thrombopenic Purpura, Thrombotic
Thrombotic thrombocytopenic purpura (disorder)
Thrombotic Thrombocytopenic Purpura
Thrombotic Thrombopenic Purpura
TTP - Thrombotic thrombocytopenic purpura
TTP

External Source Codes: 
NCI Thesaurus Code C78797 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
Contributing_Source CTRP NCI
Contributing_Source MedDRA NCI
Contributing_Source NICHD NCI
CTV3ID G7560 SNOMEDCT_US
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_FIRST_PUBLISHED 2011-01-28 PDQ
DATE_LAST_MODIFIED 2011-01-28 PDQ
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DISEASE_IDENTIFIER_ID 14526 GARD
DISEASE_IDENTIFIER_ID 14527 GARD
DISEASE_IDENTIFIER_ID 14528 GARD
DX 19650101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
HN 1986; use PURPURA, THROMBOTIC THROMBOPENIC 1965-1985 MSH
IDENTIFIER_TYPE_ID 1 GARD
IS_ACTIVE true GARD
MDA 19990101 MSH
MESH_DEFINITION An acquired, congenital, or familial disorder caused by PLATELET AGGREGATION with THROMBOSIS in terminal arterioles and capillaries. Clinical features include THROMBOCYTOPENIA; HEMOLYTIC ANEMIA; AZOTEMIA; FEVER; and thrombotic microangiopathy. The classical form also includes neurological symptoms and end-organ damage, such as RENAL FAILURE. NDFRT
MESH_DUI D011697 NDFRT
MESH_NAME Purpura, Thrombotic Thrombocytopenic NDFRT
MESH_UI M0018188 NDFRT
MMR 20130708 MSH
MN C15.378.100.802.687.680 MSH
MN C15.378.140.855.925.750.680 MSH
MN C15.378.925.850 MSH
MN C23.550.414.950.687.680 MSH
MN C23.888.885.687.687.680 MSH
NCI_THESAURUS_CODE C78797 PDQ
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Thrombotic Thrombocytopenic Purpura NCI
NUI N0000002557 NDFRT
ORIG_STY Secondary related condition PDQ
PM 1986; see PURPURA, THROMBOTIC THROMBOPENIC 1965-1985 MSH
PRIMARY_PATH 10043648$10043555$10035534$10005329$Thrombotic thrombocytopenic purpura$Thrombocytopenias$Platelet disorders$Blood and lymphatic system disorders MDR
PRIMARY_SOC 10005329 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RXAUI 3199704 RXNORM
RXAUI 3226318 RXNORM
RXAUI 3226319 RXNORM
RXAUI 3226320 RXNORM
RXAUI 3288048 RXNORM
RXAUI 5932359 RXNORM
RXCUI 1024310 RXNORM
SMQ_TERM_ADDVERSION 10.0 MDR
SMQ_TERM_ADDVERSION 13.0 MDR
SMQ_TERM_ADDVERSION 16.0 MDR
SMQ_TERM_ADDVERSION 9.0 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 10.0 MDR
SMQ_TERM_LMVERSION 12.0 MDR
SMQ_TERM_LMVERSION 13.0 MDR
SMQ_TERM_LMVERSION 16.0 MDR
SMQ_TERM_SCOPE 1 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 126729006 NDFRT
SNOMED_CID 78129009 NDFRT
SNOMEDID DC-61130 SNOMEDCT_US
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS M31.1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~M31.1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS M31.1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF DRUG INDUCED THROMBOTIC THROMBOCYTOPENIC PURPURA CHOOSE M31.1 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF DRUG INDUCED THROMBOTIC THROMBOCYTOPENIC PURPURA CHOOSE T50.901? | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | EPISODE OF CARE INFORMATION NEEDED | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~MAP SOURCE CONCEPT CANNOT BE CLASSIFIED WITH AVAILABLE DATA SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447638001 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447639009 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 441322009 | Drug induced thrombotic thrombocytopenic purpura (disorder) | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~OTHERWISE TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~M31.1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~T50.901? SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~ SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~G7560 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~DC-61130 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T034585 MSH
TERMUI T034586 MSH
TERMUI T034587 MSH
TERMUI T679329 MSH
TERMUI T740806 MSH
TERMUI T843443 MSH
TH GHR (2014) MSH
TH NLM (1964) MSH
TH NLM (1992) MSH
TH NLM (2008) MSH
TH NLM (2014) MSH
TH ORD (2010) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0034155

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