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Precocious Puberty (CUI C0034013) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0034013

NCI Thesaurus Code: C79704  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: Unusually early sexual maturity.

GARD Definition: Precocious puberty is when a person's sexual and physical traits develop and mature earlier than normal. Normal puberty typically begins between ages 10 and 14 for girls, and ages 12 and 16 for boys. The start of puberty depends on various factors such as family history, nutrition and gender. The cause of precocious puberty is not always known. Some cases of precocious puberty are due to conditions that cause changes in the body's release of hormones. Treatment involves medications that can stop the release of sexual hormones. - this information is from GARD/ORDR/NCATS.

HPO Definition: The onset of secondary sexual characteristics before a normal age. Although it is difficult to define normal age ranges because of the marked variation with which puberty begins in normal children, precocious puberty can be defined as the onset of puberty before the age of 8 years in girls or 9 years in boys. [HPO:probinson]

CTCAE Definition: A disorder characterized by unusually early development of secondary sexual features; the onset of sexual maturation begins usually before age 8 for girls and before age 9 for boys.

NICHD Definition: Onset and progression of breast development before the age of 8 years in girls and testicular enlargement before the age of 9 years in boys.

CSP Definition: unusually early sexual maturity.

MSH Definition: Development of SEXUAL MATURATION in boys and girls at a chronological age that is 2.5 standard deviations below the mean age at onset of PUBERTY in the population. This early maturation of the hypothalamic-pituitary-gonadal axis results in sexual precocity, elevated serum levels of GONADOTROPINS and GONADAL STEROID HORMONES such as ESTRADIOL and TESTOSTERONE.

Synonyms & Abbreviations: (see Synonym Details)
Accelerated sexual maturation
ACCELERATED SEXUAL MATURITY
Early onset of puberty
Early puberty
Familial precocious puberty
Idiopathic sexual precocity
MATURATION SEX ACCELERATED
Precocious puberty (disorder)
Precocious puberty NOS
precocious puberty
Precocious sexual development (disorder)
Precocious sexual development
Premature puberty
PUBERTY PRECOCIOUS
Puberty, Precocious [Disease/Finding]
Puberty, Precocious
Sexual precocity NOS
SEXUAL PRECOCITY
True precocious puberty

External Source Codes: 
NCI Thesaurus Code C79704 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN human only MSH
AQL BL CF CI CL CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VI MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
Contributing_Source MedDRA NCI
Contributing_Source NICHD NCI
CTV3ID XE10t SNOMEDCT_US
CTV3ID XUZ1p SNOMEDCT_US
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2586-8869 CSP
DISEASE_IDENTIFIER_ID 5470 GARD
DISEASE_IDENTIFIER_ID 5471 GARD
DISEASE_IDENTIFIER_ID 5472 GARD
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20030731 SNOMEDCT_US
EXCLUDES1 Albright (-McCune) (-Sternberg) syndrome (Q78.1) ICD10CM
EXCLUDES1 central precocious puberty (E22.8) ICD10CM
EXCLUDES1 congenital adrenal hyperplasia (E25.0) ICD10CM
EXCLUDES1 female heterosexual precocious pseudopuberty (E25.-) ICD10CM
EXCLUDES1 male isosexual precocious pseudopuberty (E25.-) ICD10CM
HAS_GARD_PAGE true GARD
IAN DEFAULT ICD10
IDENTIFIER_TYPE_ID 1 GARD
INCLUSION_TERM Precocious menstruation ICD10
IS_ACTIVE true GARD
IS_RARE true GARD
IS_SPANISH false GARD
MDA 19990101 MSH
MESH_DEFINITION Development of SEXUAL MATURATION in boys and girls at a chronological age that is 2.5 standard deviations below the mean age at onset of PUBERTY in the population. This early maturation of the hypothalamic-pituitary-gonadal axis results in sexual precocity, elevated serum levels of GONADOTROPINS and GONADAL STEROID HORMONES such as ESTRADIOL and TESTOSTERONE. NDFRT
MESH_DUI D011629 NDFRT
MESH_NAME Puberty, Precocious NDFRT
MESH_UI M0018083 NDFRT
MMR 20090706 MSH
MN C19.391.693 MSH
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Precocious Puberty NCI
NUI N0000002535 NDFRT
ORDER_NO 04364 ICD10CM
PRIMARY_PATH 10058084$10014692$10014701$10014698$Precocious puberty$Endocrine abnormalities of puberty$Endocrine disorders of gonadal function$Endocrine disorders MDR
PRIMARY_SOC 10014698 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/7446/precocious-puberty/resources/1 GARD
REF orcid.org/0000-0001-5208-3432 HPO
RXAUI 3223194 RXNORM
RXAUI 3225976 RXNORM
RXAUI 3225977 RXNORM
RXCUI 1023098 RXNORM
SNOMED_CID 123527003 NDFRT
SNOMED_CID 400179000 NDFRT
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS E30.1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~E30.1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS E30.1 | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~E30.1 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XE10t SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUZ1p SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T034340 MSH
TERMUI T609186 MSH
TH NLM (1966) MSH
TH NLM (2006) MSH
TH ORD (2010) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0034013

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