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Propofol (CUI C0033487) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0033487

NCI Thesaurus Code: C29384  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Pharmacologic Substance

NCIt Definition: A hypnotic alkylphenol derivative. Formulated for intravenous induction of sedation and hypnosis during anesthesia, propofol facilitates inhibitory neurotransmission mediated by gamma-aminobutyric acid (GABA). This agent is associated with minimal respiratory depression and has a short half-life with a duration of action of 2 to 10 minutes.

PDQ Definition: A hypnotic alkylphenol derivative. Formulated for intravenous induction of sedation and hypnosis during anesthesia, propofol facilitates inhibitory neurotransmission mediated by gamma-aminobutyric acid (GABA). This agent is associated with minimal respiratory depression and has a short half-life with a duration of action of 2 to 10 minutes. Check for active clinical trials using this agent. (NCI Thesaurus)

MSH Definition: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.

Synonyms & Abbreviations: (see Synonym Details)
2,6 Diisopropylphenol
2,6-Bis(1-methylethyl)phenol
2,6-Diisopropylphenol
Astra Brand of Propofol
AstraZeneca Brand of Propofol
Diprivan
Disoprivan
Disoprofol
Phenol, 2,6-bis(1-methylethyl)-
Product containing propofol (medicinal product)
Product containing propofol
Propofol (substance)
Propofol [Chemical/Ingredient]
Propofolum
propofol
Zeneca Brand of Propofol

External Source Codes: 
NCI Thesaurus Code C29384 (see NCI Thesaurus info)
CAS Registry Number 2078-54-8 (see NLM ChemIDplus info)
FDA UNII Code YI7VU623SF
NSC Code 5105 (see NCI DTP info)
PDQ Closed Trial Search ID 461189
PDQ Open Trial Search ID 461189 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:44915 NCI
Chemical_Formula C12H18O NCI
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID o15.. SNOMEDCT_US
CTV3ID XUWw8 SNOMEDCT_US
DATE_FIRST_PUBLISHED 2005-12-22 PDQ
DATE_LAST_MODIFIED 2007-07-11 PDQ
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DX 19900101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20030131 SNOMEDCT_US
FDA_UNII_CODE YI7VU623SF DRUGBANK
FDA_UNII_CODE YI7VU623SF NDFRT
FX D000072736 MSH
HN 90 MSH
HN Introduced 2000. AOD
LEVEL Ingredient NDFRT
LT TRD MSH
LT TRD MTH
LT TRD PDQ
MDA 19890608 MSH
MESH_DEFINITION An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS. NDFRT
MESH_DUI D015742 NDFRT
MESH_NAME Propofol NDFRT
MESH_UI M0024130 NDFRT
MMR 20160701 MSH
MN D02.455.426.559.389.657.773 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NCI_THESAURUS_CODE C29384 PDQ
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006386 NDFRT
NUI N0000147620 NDFRT
ORIG_STY Drug/agent PDQ
PA D006993 MSH
PA D018686 MSH
PM 90 MSH
RN 0 MSH
RN YI7VU623SF MSH
RR 2078-54-8 (Propofol) MSH
RXAUI 1090300 RXNORM
RXAUI 2074054 RXNORM
RXAUI 2597961 RXNORM
RXAUI 2771847 RXNORM
RXAUI 281156 RXNORM
RXAUI 3092336 RXNORM
RXAUI 3092344 RXNORM
RXAUI 3148420 RXNORM
RXAUI 3216635 RXNORM
RXAUI 3216636 RXNORM
RXAUI 3219741 RXNORM
RXAUI 3224227 RXNORM
RXAUI 3224228 RXNORM
RXAUI 6378860 RXNORM
RXCUI 196459 RXNORM
RXCUI 8782 RXNORM
RXN_BN_CARDINALITY single RXNORM
SID APRD01201 DRUGBANK
SID DB05893 DRUGBANK
SID EXPT02558 DRUGBANK
SPL_SET_ID 28d7ba00-f824-4e55-139a-03f509c099db MTHSPL
SPL_SET_ID 3d382e4e-dab1-47d6-a509-49f5f38bfbfe MTHSPL
SPL_SET_ID 6f8bebf9-d87b-469a-911a-21135ba841ae MTHSPL
SPL_SET_ID 7603f1ba-cfbd-4ec5-881a-13f4832c9893 MTHSPL
SPL_SET_ID 7699dd48-068e-4f74-bb50-c0f6cc531263 MTHSPL
SPL_SET_ID 9c7679bd-31d1-4a62-b7b5-d0c52be1fccd MTHSPL
SPL_SET_ID a240bf74-5dee-ab9f-65fc-09565dc32f44 MTHSPL
SPL_SET_ID C0403897-79F5-4086-94B7-56C0CB7EE65C MTHSPL
SPL_SET_ID d1ae9e26-ffd6-43df-bbd6-869cdede6afe MTHSPL
SPL_SET_ID dd28195e-a481-4d7a-b578-488fe37ecc09 MTHSPL
SPL_SET_ID e3105799-a4b6-f3f4-e6e2-b2b29bbdb538 MTHSPL
SPL_SET_ID e56dadc5-c771-4eb3-91ca-d3a59fc29eaa MTHSPL
SPL_SET_ID ea7567c4-4bf9-58f1-1ccb-65d1a1a8c620 MTHSPL
SPL_SET_ID ee0c3437-614d-4631-a061-257f5f60c70b MTHSPL
SPL_SET_ID ef14e332-51ac-ea97-3542-9bc92557dbed MTHSPL
SPL_SET_ID fa93f173-7858-4d88-860e-76ab97e65c2f MTHSPL
SPL_SET_ID fee3bd4a-ade3-41fa-839a-48e9af69bcf4 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~o15.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUWw8 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T046692 MSH
TERMUI T046694 MSH
TERMUI T046696 MSH
TERMUI T046697 MSH
TERMUI T046698 MSH
TERMUI T619237 MSH
TERMUI T619238 MSH
TERMUI T619239 MSH
TERMUI T619240 MSH
TH AU MSH
TH BAN (19XX) MSH
TH CA MSH
TH DE MSH
TH ES MSH
TH FDA SRS (2014) MSH
TH FR MSH
TH INN (19XX) MSH
TH MX MSH
TH NLM (1990) MSH
TH NLM (1996) MSH
TH NLM (1999) MSH
TH NLM (2006) MSH
TH UK MSH
TH USAN (1984) MSH
TH USP (19XX) MSH
TH US MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^2114^Active/Master NDFRT
VANDF_RECORD 50.6^2145^Active/Master NDFRT
VUID 4019500 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0033487

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