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Progesterone (CUI C0033308) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0033308

NCI Thesaurus Code: C2297  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Hormone

NCIt Definition: Produced in the corpus luteum and by the placenta, as an antagonist of estrogens. Promotes proliferation of uterine mucosa and the implantation of the blastocyst, prevents further follicular development.

NCI-GLOSS Definition: A type of hormone made by the body that plays a role in the menstrual cycle and pregnancy. Progesterone can also be made in the laboratory. It may be used as a type of birth control and to treat menstrual disorders, infertility, symptoms of menopause, and other conditions.

CSP Definition: principal progestational hormone, secreted by the corpus luteum, placenta, and in minute amounts by the adrenal cortex; it prepares the uterus for the reception and development of the fertilized ovum; it acts on the mammary glands and on the brain; it serves as an intermediate in the biosynthesis of sex steroids and adrenal corticosteroids.

MSH Definition: The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.

Synonyms & Abbreviations: (see Synonym Details)
(S)-4-Pregnene-3,20-dione
(S)-Pregn-4-en-3,20-dione
(S)-Progesterone
17alpha-Progesterone
17α-progesterone
Corpus Luteum Hormone
delta(4)-Pregnene-3,20-dione
Delta4-pregnene-3,20-dione
Gelbkoerperhormon
Lutogynon
Pregn-4-ene-3,20-dione
Pregnenedione
Progesterona
Progesterone [Chemical/Ingredient]
progesterone
Progesteronum
Progesteron
Progestérone

External Source Codes: 
NCI Thesaurus Code C2297 (see NCI Thesaurus info)
CAS Registry Number 57-83-0 (see NLM ChemIDplus info)
NSC Code 64377 (see NCI DTP info)

Other Properties: Property Definitions
Name Value Source
AQL AA AD AE AG AI AN BI BL CF CH CL CS CT DF EC GE HI IM IP ME PD PH PK PO RE SD SE ST TO TU UR MSH
CHEBI_ID CHEBI:17026 NCI
CITE breastNLP RADLEX
Contributing_Source CTRP NCI
DATE_CREATED 2/17/2016 RADLEX
DATE_LAST_MODIFIED 3.14 RADLEX
DC 1 MSH
DID 2422-5382 CSP
DX 19660101 MSH
FDA_UNII_CODE 4G7DS2Q64Y DRUGBANK
FDA_UNII_CODE 4G7DS2Q64Y NDFRT
FX D011980 MSH
LAST_CHANGES_TO_CLASS new RADLEX
LEVEL Ingredient NDFRT
MDA 19990101 MSH
MESH_DEFINITION The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS. NDFRT
MESH_DUI D011374 NDFRT
MESH_NAME Progesterone NDFRT
MESH_UI M0017672 NDFRT
MMR 20160531 MSH
MN D04.210.500.745.745.654.829 MSH
MN D06.472.334.734.623 MSH
MN D06.472.334.851.687.750 MSH
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000005934 NDFRT
NUI N0000145841 NDFRT
PA D011372 MSH
RN 4G7DS2Q64Y MSH
RR 2000-66-0 ((17 alpha)-isomer) MSH
RR 2755-10-4 ((9 beta,10 alpha)-isomer) MSH
RR 57-83-0 (Progesterone) MSH
RR 59952-90-8 ((13 alpha,17 alpha)-(+-)-isomer) MSH
RXAUI 3216411 RXNORM
RXAUI 3216412 RXNORM
RXAUI 3223228 RXNORM
RXAUI 3223404 RXNORM
RXAUI 3223868 RXNORM
RXAUI 3223883 RXNORM
RXCUI 8727 RXNORM
SID APRD00700 DRUGBANK
TERMUI T033552 MSH
TERMUI T527786 MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH NLM (1963) MSH
TH NLM (2004) MSH
TH USP (19XX) MSH
VANDF_RECORD 50.416^45^Active/Master NDFRT
VANDF_RECORD 50.6^23^Active/Master NDFRT
VUID 4017453 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0033308

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