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Plague (CUI C0032064) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0032064

NCI Thesaurus Code: C85015  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: A Gram-negative bacterial infection caused by Yersinia pestis. It is usually transmitted to humans from bites of infected rodent fleas. It is manifested as a bubonic, septicemic, or pneumonic plague. In bubonic plague, the lymph nodes adjacent to the site of the skin bite are infected and enlarged. In septicemic plague, the infection spreads directly through the bloodstream. In pneumonic plague, the infection spreads to the lungs either following bubonic plague, or by inhalation of infective droplets. If untreated, it may lead to death.

MEDLINEPLUS Definition: 

Plague is an infection caused by the bacterium Yersinia pestis. The bacteria are found mainly in rats and in the fleas that feed on them. People and other animals can get plague from rat or flea bites. In the past, plague destroyed entire civilizations. Today plague is uncommon, due to better living conditions and antibiotics.

There are three forms of plague:

  • Bubonic plague causes the tonsils, adenoids, spleen, and thymus to become inflamed. Symptoms include fever, aches, chills, and tender lymph glands.
  • In septicemic plague, bacteria multiply in the blood. It causes fever, chills, shock, and bleeding under the skin or other organs.
  • Pneumonic plague is the most serious form. Bacteria enter the lungs and cause pneumonia. People with the infection can spread this form to others. This type could be a bioterror agent.

Lab tests can diagnose plague. Treatment is a strong antibiotic. There is no vaccine.

NIH: National Institute of Allergy and Infectious Diseases

NICHD Definition: An infection that is caused by Yersinia pestis, which is usually transmitted to humans from infected rodent fleas. It is manifested as a bubonic (lymph node), pneumonic, or septicemic plague. In bubonic plague, the lymph nodes adjacent to the site of the skin bite are infected and enlarged. In pneumonic plague, the infection spreads to the lungs, either following bubonic plague or by inhalation of infective droplets. The term septicemic plague is used when the primary manifestation is a bloodstream infection.

CSP Definition: acute infectious disease caused by Yersinia pestis that affects humans, wild rodents, and their ectoparasites; bubonic plague is the most common form.

MSH Definition: An acute infectious disease caused by YERSINIA PESTIS that affects humans, wild rodents, and their ectoparasites. This condition persists due to its firm entrenchment in sylvatic rodent-flea ecosystems throughout the world. Bubonic plague is the most common form.

Synonyms & Abbreviations: (see Synonym Details)
Infection by Yersinia pestis
Pestilential fever
Pest
Plague (disorder)
Plague [Disease/Finding]
Plague NOS
Plague, unspecified
Plague
Unspecified plague
Yersinia pestis disease
Yersinia pestis infection

External Source Codes: 
NCI Thesaurus Code C85015 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN Pasteurella pestis or Yersinia pestis infection only; swine plague = HEMORRHAGIC SEPTICEMIA /vet (IM) + SWINE DISEASES (IM) but do not confuse with African swine plague ( = AFRICAN SWINE FEVER) MSH
ANSWER_CODE 10440 LNC
ANSWER_CODE_SYSTEM NNDSS LNC
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH TM UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
Contributing_Source NICHD NCI
CTV3ID A20.. SNOMEDCT_US
DATE_CREATED 05/28/2002 MEDLINEPLUS
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DID 0368-3331 CSP
DX 19660101 MSH
EFFECTIVE_TIME 20040731 SNOMEDCT_US
EXTERNALLY_DEFINED N LNC
IAN DEFAULT ICD10
INCLUSION_TERM infection due to Yersinia pestis ICD10
MDA 19990101 MSH
MESH_DEFINITION An acute infectious disease caused by YERSINIA PESTIS that affects humans, wild rodents, and their ectoparasites. This condition persists due to its firm entrenchment in sylvatic rodent-flea ecosystems throughout the world. Bubonic plague is the most common form. NDFRT
MESH_DUI D010930 NDFRT
MESH_NAME Plague NDFRT
MESH_UI M0016945 NDFRT
MMR 20100625 MSH
MN C01.252.400.310.980.745 MSH
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/plague.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Amharic https://www.nlm.nih.gov/medlineplus/languages/plague.html#Amharic MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Hmong https://www.nlm.nih.gov/medlineplus/languages/plague.html#Hmong MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/plague.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Institute of Allergy and Infectious Diseases http://www.niaid.nih.gov/ MEDLINEPLUS
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Plague NCI
NUI N0000002415 NDFRT
ORDER_NO 00154 ICD10CM
ORDER_NO 00161 ICD10CM
PRIMARY_PATH 10035148$10048249$10004018$10021881$Plague$Yersinia infections$Bacterial infectious disorders$Infections and infestations MDR
PRIMARY_SOC 10021881 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RXAUI 3221284 RXNORM
RXAUI 3221287 RXNORM
RXCUI 1027188 RXNORM
SNOMED_CID 186290009 NDFRT
SNOMED_CID 58750007 NDFRT
SOS Includes: infection by Yersinia [Pasteurella] pestis ICD9CM
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS A20.9 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~A20.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS A20.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF AMBULATORY PLAGUE CHOOSE A20.8 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF BUBONIC PLAGUE CHOOSE A20.0 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF CELLULOCUTANEOUS PLAGUE CHOOSE A20.1 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF GASTROENTERIC PLAGUE CHOOSE A20.8 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF PLAGUE MENINGITIS CHOOSE A20.3 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF PNEUMONIC PLAGUE CHOOSE A20.2 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF SEPTICEMIC PLAGUE CHOOSE A20.7 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447639009 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~4 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~5 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~6 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~7 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~8 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 186284005 | Plague meningitis | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 186287003 | Ambulatory plague | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 240384004 | Gastroenteric plague | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 38976008 | Pneumonic plague | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 43484003 | Cellulocutaneous plague | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 50797007 | Bubonic plague | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 9012003 | Septicemic plague | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~OTHERWISE TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~A20.0 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~A20.1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~A20.2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~A20.3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~A20.7 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~A20.8 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~A20.9 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~A20.. SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T032192 MSH
TH ORD (2010) MSH
TH POPLINE (1981) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

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