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Pentaerythritol Tetranitrate (CUI C0030858) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0030858

NCI Thesaurus Code: C47660  (see NCI Thesaurus info)

Semantic Type: Pharmacologic Substance

Semantic Type: Organic Chemical

NCIt Definition: The lipid soluble polyol ester of nitric acid belonging to the family of nitrovasodilators that exhibit vasodilatory property. Pentaerythritol tetranitrate releases free nitric oxide (NO) after denitration reaction, which triggers NO-dependent signaling transduction involving soluble guanylate cyclase (sGC). NO binds reversibly to the ferrous-heme center of sGC, thereby causes conformational change and activates the enzyme. Activation results in increasing cellular levels of cyclic guanosine monophosphate (cGMP) within vascular smooth muscle, which results in vasodilation mediated by cGMP-dependent protein kinases. Furthermore, this agent causes arterial and venous bed dilation in a dose-dependent manner.

MSH Definition: A vasodilator with general properties similar to NITROGLYCERIN but with a more prolonged duration of action. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1025)

Synonyms & Abbreviations: (see Synonym Details)
1,3-Dinitrato-2,2-bis(nitratomethyl)propane
1,3-Propanediol, 2,2-bis((nitrooxy)methyl)-, dinitrate (ester)
1,3-Propanediol, 2,2-bis((nitrooxy)methyl)-, Dinitrate(ester)
Erynite
Nitropentaerythrol
Pentaerithrityl tetranitrate
Pentaerythritol tetranitrate (product)
Pentaerythritol tetranitrate (substance)
Pentaerythritol Tetranitrate [Chemical/Ingredient]
PENTAERYTHRITOL TETRANITRATE
Pentafin
Peritrate
PETN
Tetranitrate, Pentaerythritol
Vasolat

External Source Codes: 
NCI Thesaurus Code C47660 (see NCI Thesaurus info)
CAS Registry Number 78-11-5 (see NLM ChemIDplus info)
FDA UNII Code 10L39TRG1Z

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:25879 NCI
Chemical_Formula C5H8N4O12 NCI
Contributing_Source FDA NCI
CTV3ID bl4.. SNOMEDCT_US
CTV3ID XUWmb SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20030131 SNOMEDCT_US
FDA_UNII_CODE 10L39TRG1Z NDFRT
LEVEL Ingredient NDFRT
LT TRD MSH
MDA 19990101 MSH
MESH_DEFINITION A vasodilator with general properties similar to NITROGLYCERIN but with a more prolonged duration of action. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1025) NDFRT
MESH_DUI D010417 NDFRT
MESH_NAME Pentaerythritol Tetranitrate NDFRT
MESH_UI M0016166 NDFRT
MMR 20160701 MSH
MN D02.033.455.706.690 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000005705 NDFRT
NUI N0000146783 NDFRT
PA D014665 MSH
RN 0 MSH
RN 10L39TRG1Z MSH
RR 78-11-5 (Pentaerythritol Tetranitrate) MSH
RXAUI 2072857 RXNORM
RXAUI 258243 RXNORM
RXAUI 3091220 RXNORM
RXAUI 3212853 RXNORM
RXAUI 3212854 RXNORM
RXAUI 3218740 RXNORM
RXAUI 3218741 RXNORM
RXCUI 7992 RXNORM
SUBSET_MEMBER 900000000000497000~MAPTARGET~bl4.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUWmb SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T030759 MSH
TERMUI T030760 MSH
TH BAN (19XX) MSH
TH FDA SRS (2014) MSH
TH USP (19XX) MSH
TH US MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^1057^Active/Master NDFRT
VANDF_RECORD 50.6^1081^Active/Master NDFRT
VUID 4018459 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0030858

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