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Paromomycin (CUI C0030576) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0030576

NCI Thesaurus Code: C61878  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Antibiotic

NCIt Definition: An aminoglycoside antibiotic derived from Streptomyces rimosus var. paromomycinus, with amebicidal and antibacterial activity. Paromomycin binds specifically to the RNA oligonucleotide at the A site of bacterial 30S ribosomes, thereby causing misreading and premature termination of translation, thereby leading to inhibition of protein synthesis followed by cell death.

MSH Definition: An oligosaccharide antibiotic produced by various STREPTOMYCES.

Synonyms & Abbreviations: (see Synonym Details)
(1R,2R,3S,4R,6S)-4,6-Diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside
Aminosidine
Aminosidin
Antibiotic 503-3
Antibiotic SF 767B
Catenulin
Crestomycin
D-Streptamine, O-2-amino-2-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1-3)-beta-D-ribofuranosyl-(1-5))-2-deoxy-
Estomycin
Gabromycin
Hydroxymycin
Monomycin a
Neomycin e
O-2,6-Diamino-2,6-Dideoxy-Beta-L-Idopyranosyl-(1->3)-O-Beta-D-Ribofuranosyl-(1->5)-O-(2-Amino-2-Deoxy-Alpha-D-Glucopyranosyl-(1->4))-2-Deoxystreptamine
O-2-Amino-2-Deoxy-Alpha-D-Glucopyranosyl-(1->4)-O-(O-2,6-Diamino-2,6-Dideoxy-Beta-L-Idopyranosyl-(1->3)-Beta-D-Ribofuranosyl-(1->5))-2-Deoxy-D-Streptamine
Paramomycin
Paromomicina
Paromomycin (substance)
Paromomycin [Chemical/Ingredient]
Paromomycin i
Paromomycine
Paromomycinum
Paromomycin
Paucimycinum
Paucimycin
Product containing paromomycin (medicinal product)
Product containing paromomycin
Quintomycin C
R-400
Zygomycin a1

External Source Codes: 
NCI Thesaurus Code C61878 (see NCI Thesaurus info)
CAS Registry Number 7542-37-2 (see NLM ChemIDplus info)
CAS Registry Number 59-04-1 (see NLM ChemIDplus info)
FDA UNII Code 61JJC8N5ZK

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BI BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:7934 NCI
Chemical_Formula C23H45N5O14 NCI
Contributing_Source FDA NCI
CTV3ID XUCtI SNOMEDCT_US
CTV3ID XUUVW SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20160131 SNOMEDCT_US
FDA_UNII_CODE 61JJC8N5ZK DRUGBANK
FDA_UNII_CODE 61JJC8N5ZK NDFRT
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
MDA 19990101 MSH
MESH_DEFINITION An oligosaccharide antibiotic produced by various STREPTOMYCES. NDFRT
MESH_DUI D010303 NDFRT
MESH_NAME Paromomycin NDFRT
MESH_UI M0015969 NDFRT
MMR 20160701 MSH
MN D09.408.051.623.635 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006544 NDFRT
NUI N0000147963 NDFRT
PA D000563 MSH
PA D000900 MSH
RN 61JJC8N5ZK MSH
RR 120247-71-4 (phosphate) MSH
RR 1263-89-4 (sulfate) MSH
RR 35665-49-7 (sulfate (2:5)) MSH
RR 68538-83-0 (beta-D-glucopyranosyl-isomer) MSH
RR 7205-49-4 (sulfate (1:1)) MSH
RR 7542-37-2 (Paromomycin) MSH
RXAUI 2072780 RXNORM
RXAUI 256625 RXNORM
RXAUI 3108424 RXNORM
RXAUI 3130946 RXNORM
RXAUI 3137833 RXNORM
RXAUI 3155600 RXNORM
RXAUI 3174084 RXNORM
RXAUI 3204860 RXNORM
RXAUI 3212224 RXNORM
RXAUI 3212225 RXNORM
RXAUI 3217977 RXNORM
RXAUI 3218298 RXNORM
RXAUI 3218301 RXNORM
RXAUI 5931999 RXNORM
RXAUI 6395744 RXNORM
RXCUI 7934 RXNORM
SPL_SET_ID 22494bde-a53e-4b3c-a89b-0ccda341f28f MTHSPL
SPL_SET_ID 2b5b3dae-b406-1e2e-e054-00144ff88e88 MTHSPL
SPL_SET_ID cc0f4113-e627-4caf-b2d4-95b4106e57f5 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUCtI SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUUVW SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T030435 MSH
TERMUI T030436 MSH
TERMUI T030437 MSH
TERMUI T030438 MSH
TERMUI T030439 MSH
TERMUI T030440 MSH
TERMUI T030441 MSH
TERMUI T030442 MSH
TH BAN (19XX) MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^2503^Active/Master NDFRT
VANDF_RECORD 50.6^966^Active/Master NDFRT
VUID 4019878 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0030576

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