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Parkinson Disease (CUI C0030567) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0030567

NCI Thesaurus Code: C26845  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: A progressive degenerative disorder of the central nervous system characterized by loss of dopamine producing neurons in the substantia nigra and the presence of Lewy bodies in the substantia nigra and locus coeruleus. Signs and symptoms include tremor which is most pronounced during rest, muscle rigidity, slowing of the voluntary movements, a tendency to fall back, and a mask-like facial expression.

RADLEX Definition: A progressive, degenerative neurologic disease characterized by a tremor that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. lewy bodies are present in the substantia nigra and locus coeruleus but may also be found in a related condition (lewy body disease, diffuse) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75) [MeSH]

GARD Definition: Parkinson disease belongs to a group of conditions called movement disorders. The four main symptoms are tremor, or trembling in hands, arms, legs, jaw, or head; rigidity, or stiffness of the limbs and trunk; bradykinesia, or slowness of movement; and postural instability, or impaired balance. These symptoms usually begin gradually and worsen with time.  As they become more pronounced, patients may have difficulty walking, talking, or completing other simple tasks.  Not everyone with one or more of these symptoms has Parkinson disease, as the symptoms sometimes appear in other diseases as well.  Parkinson disease affects about 1 to 2 percent of people over the age of 60 years and the chance of developing Parkinson disease increases as we age. Although some Parkinson disease cases appear to be hereditary, and a few can be traced to specific genetic mutations, most cases are sporadic and occur in people with no apparent history of the disorder in their family.  Many researchers now believe that Parkinson disease results from a combination of genetic susceptibility and exposure to one or more environmental factors that trigger the disease.   - this information is from GARD/ORDR/NCATS.

MEDLINEPLUS Definition: 

Parkinson's disease (PD) is a type of movement disorder. It happens when nerve cells in the brain don't produce enough of a brain chemical called dopamine. Sometimes it is genetic, but most cases do not seem to run in families. Exposure to chemicals in the environment might play a role.

Symptoms begin gradually, often on one side of the body. Later they affect both sides. They include

  • Trembling of hands, arms, legs, jaw and face
  • Stiffness of the arms, legs and trunk
  • Slowness of movement
  • Poor balance and coordination

As symptoms get worse, people with the disease may have trouble walking, talking, or doing simple tasks. They may also have problems such as depression, sleep problems, or trouble chewing, swallowing, or speaking.

There is no lab test for PD, so it can be difficult to diagnose. Doctors use a medical history and a neurological examination to diagnose it.

PD usually begins around age 60, but it can start earlier. It is more common in men than in women. There is no cure for PD. A variety of medicines sometimes help symptoms dramatically. Surgery and deep brain stimulation (DBS) can help severe cases. With DBS, electrodes are surgically implanted in the brain. They send electrical pulses to stimulate the parts of the brain that control movement.

NIH: National Institute of Neurological Disorders and Stroke

NCI-GLOSS Definition: A progressive disorder of the nervous system marked by muscle tremors, muscle rigidity, decreased mobility, stooped posture, slow voluntary movements, and a mask-like facial expression.

CSP Definition: progressive, degenerative disorder of the nervous system characterized by tremors, rigidity, bradykinesia, postural instability, and gait abnormalities; caused by a loss of neurons and a decrease of dopamine in the basal ganglia.

MSH Definition: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)

Synonyms & Abbreviations: (see Synonym Details)
DISEASE PARKINSON'S
Idiopathic Parkinson Disease
IDIOPATHIC PARKINSON DIS
Idiopathic Parkinson's Disease
Idiopathic Parkinsonism
IDIOPATHIC PARKINSONS DIS
Lewy Body Parkinson Disease
LEWY BODY PARKINSON DIS
Lewy Body Parkinson's Disease
Morbus Parkinson
PALSY SHAKING
PALSY, SHAKING
PARALYSIS AGITANS <PARKINSONISM>
Paralysis Agitans
PARKINSON DIS IDIOPATHIC
Parkinson Disease [Disease/Finding]
Parkinson Disease, Idiopathic
PARKINSON DISEASE
PARKINSON DIS
Parkinson's disease (disorder)
Parkinson's disease NOS
Parkinson's Disease, Idiopathic
Parkinson's Disease, Lewy Body
Parkinson's disease
Parkinson's dis
PARKINSON'S SYNDROME
Parkinson`s disease
Parkinsonism, Primary
PARKINSONS DIS IDIOPATHIC
PARKINSONS DIS LEWY BODY
Parkinsons disease
PARKINSONS DIS
PD - Parkinson's disease
Primary parkinsonism
Shaking palsy
SYNDROME PARKINSON'S

External Source Codes: 
NCI Thesaurus Code C26845 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN drug ther: consider also ANTIPARKINSON AGENTS; /chem ind = PARKINSON DISEASE, SECONDARY/chem ind MSH
AQL BL CF CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CTV3ID F12.. SNOMEDCT_US
DATE_CREATED 11/14/1998 MEDLINEPLUS
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2057-3689 CSP
DISEASE_IDENTIFIER_ID 21581 GARD
DISEASE_IDENTIFIER_ID 21582 GARD
DISEASE_IDENTIFIER_ID 21583 GARD
DISEASE_IDENTIFIER_ID 21584 GARD
DX 19670101 MSH
EC chemically induced:Parkinson Disease, Secondary/chemically induced MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EXCLUDES1 dementia with Parkinsonism (G31.83) ICD10CM
FX D016631 MSH
HAS_GARD_PAGE true GARD
HN 1979(1963) MSH
IAN DEFAULT ICD10
ICE Parkinsonism or Parkinson's disease: {NOS; idiopathic; primary} ICD9CM
IDENTIFIER_TYPE_ID 1 GARD
INCLUSION_TERM Hemiparkinsonism ICD10
INCLUSION_TERM Paralysis agitans ICD10
INCLUSION_TERM Parkinsonism or Parkinson's disease: idiopathic ICD10
INCLUSION_TERM Parkinsonism or Parkinson's disease: NOS ICD10
INCLUSION_TERM Parkinsonism or Parkinson's disease: primary ICD10
IS_ACTIVE true GARD
IS_RARE false GARD
IS_SPANISH false GARD
MDA 19990101 MSH
MESH_DEFINITION A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75) NDFRT
MESH_DUI D010300 NDFRT
MESH_NAME Parkinson Disease NDFRT
MESH_UI M0015963 NDFRT
MMR 20130708 MSH
MN C10.228.140.079.862.500 MSH
MN C10.228.662.600.400 MSH
MN C10.574.812 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/parkinsonsdisease.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Arabic https://www.nlm.nih.gov/medlineplus/languages/parkinsonsdisease.html#Arabic MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Chinese - Simplified https://www.nlm.nih.gov/medlineplus/languages/parkinsonsdisease.html#Chinese - Simplified MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Chinese - Traditional https://www.nlm.nih.gov/medlineplus/languages/parkinsonsdisease.html#Chinese - Traditional MEDLINEPLUS
MP_OTHER_LANGUAGE_URL French https://www.nlm.nih.gov/medlineplus/languages/parkinsonsdisease.html#French MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Hindi https://www.nlm.nih.gov/medlineplus/languages/parkinsonsdisease.html#Hindi MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Japanese https://www.nlm.nih.gov/medlineplus/languages/parkinsonsdisease.html#Japanese MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Korean https://www.nlm.nih.gov/medlineplus/languages/parkinsonsdisease.html#Korean MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Russian https://www.nlm.nih.gov/medlineplus/languages/parkinsonsdisease.html#Russian MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Somali https://www.nlm.nih.gov/medlineplus/languages/parkinsonsdisease.html#Somali MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/parkinsonsdisease.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Institute of Neurological Disorders and Stroke http://www.ninds.nih.gov/ MEDLINEPLUS
NDFRT_KIND DISEASE_KIND NDFRT
NUI N0000002327 NDFRT
ORDER_NO 05821 ICD10CM
PM 1979; see PARKINSONISM 1967-1978, see PARALYSIS AGITANS 1963-1966 MSH
PRIMARY_PATH 10061536$10034005$10028037$10029205$Parkinson's disease$Parkinson's disease and parkinsonism$Movement disorders (incl parkinsonism)$Nervous system disorders MDR
PRIMARY_SOC 10029205 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/10251/parkinson-disease/resources/1 GARD
RXAUI 3178238 RXNORM
RXAUI 3178239 RXNORM
RXAUI 3189403 RXNORM
RXAUI 3189404 RXNORM
RXAUI 3217918 RXNORM
RXAUI 3218247 RXNORM
RXAUI 3218248 RXNORM
RXAUI 3218252 RXNORM
RXAUI 3218264 RXNORM
RXAUI 3218265 RXNORM
RXAUI 3218266 RXNORM
RXAUI 3223646 RXNORM
RXCUI 1022466 RXNORM
SMQ_TERM_ADDVERSION 10.0 MDR
SMQ_TERM_ADDVERSION 9.0 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_CAT D MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 10.0 MDR
SMQ_TERM_LMVERSION 9.0 MDR
SMQ_TERM_SCOPE 1 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 49049000 NDFRT
SNOMEDID DA-21012 SNOMEDCT_US
SOS Excludes: dementia with Parkinsonism (331.82) ICD9CM
SOS Loss of striatal dopamine due to degeneration of the substantia nigra. AOD
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS G20 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~G20 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS G20 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~G20 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~F12.. SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~DA-21012 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T030418 MSH
TERMUI T030419 MSH
TERMUI T030420 MSH
TERMUI T364505 MSH
TERMUI T364506 MSH
TERMUI T364507 MSH
TERMUI T364508 MSH
TERMUI T364509 MSH
TERMUI T364510 MSH
TERMUI T364511 MSH
TERMUI T364512 MSH
TH GHR (2014) MSH
TH NLM (1967) MSH
TH NLM (1992) MSH
TH NLM (2000) MSH
TH OMIM (2013) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

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