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Tropical Spastic Paraparesis (CUI C0030481) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0030481

Semantic Type: Disease or Syndrome

GARD Definition: HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic, progressive disease of the nervous system that affects less than 2 percent of people with HTLV-1 infection. Signs and symptoms vary but may include progressive weakness, stiff muscles, muscle spasms, backache, a 'weak' bladder, and constipation. The HTLV-1 virus can be transmitted from mother to child via breastfeeding or childbirth, from person to person through sexual contact and through blood contact, either by transfusion or by reuse of injection equipment. HTLV infection is not passed from person to person by coughing, sneezing, kissing, cuddling or daily social contact. Screening of donated blood for HTLV-1 has been done in the United States since 1988. - this information is from GARD/ORDR/NCATS.

SNOMEDCT_US Definition: A progressive chronic inflammatory disease of the central nervous system with the aetiologic agent Human T cell lymphotropic virus type I (HTLV-I), the disease is characterised by unremitting myelopathic symptoms such as spastic paraparesis, bowel and/or bladder dysfunction and sensory changes of the lower limbs.

SNOMEDCT_US Definition: A progressive chronic inflammatory disease of the central nervous system with the etiologic agent Human T cell lymphotropic virus type I (HTLV-I), the disease is characterized by unremitting myelopathic symptoms such as spastic paraparesis, bowel and/or bladder dysfunction and sensory changes of the lower limbs.

MSH Definition: A subacute paralytic myeloneuropathy occurring endemically in tropical areas such as the Caribbean, Colombia, India, and Africa, as well as in the southwestern region of Japan; associated with infection by HUMAN T-CELL LEUKEMIA VIRUS I. Clinical manifestations include a slowly progressive spastic weakness of the legs, increased reflexes, Babinski signs, incontinence, and loss of vibratory and position sensation. On pathologic examination inflammatory, demyelination, and necrotic lesions may be found in the spinal cord. (Adams et al., Principles of Neurology, 6th ed, p1239)

Synonyms & Abbreviations: (see Synonym Details)
Familial Spastic Paraparesis, Htlv 1 Associated
Familial Spastic Paraparesis, Htlv-1-Associated
HAM/TSP
HAM
HTLV I ASSOC MYELOPATHIES
HTLV I ASSOC MYELOPATHY TROPICAL SPASTIC PARAPARESIS
HTLV I ASSOC MYELOPATHY
HTLV I Associated Myelopathies
HTLV I Associated Myelopathy Tropical Spastic Paraparesis
HTLV I Associated Myelopathy
HTLV WI ASSOCIATED MYELOPATHY
HTLV-1 associated myelopathy/tropical spastic paraparesis
Htlv-1-Associated Myelopathies
Htlv-1-Associated Myelopathy
HTLV-I-Associated Myelopathies
HTLV-I-Associated Myelopathy-Tropical Spastic Paraparesis
HTLV-I-associated myelopathy
HUMAN T LYMPHOTROPIC VIRUS TYPE 1 ASSOC MYELOPATHY
Human T Lymphotropic Virus Type 1 Associated Myelopathy
Human T-cell leukaemia virus type I myelopathy
Human T-cell leukemia virus type 1 associated myelopathy/tropical spastic paraparesis
Human T-cell leukemia virus type I myelopathy
Human T-cell lymphotropic virus 1-associated myelopathy
Human T-Lymphotropic Virus Type 1 Associated Myelopathy
MYELOPATHIES HTLV I ASSOC
Myelopathies, HTLV I Associated
Myelopathies, Htlv-1-Associated
Myelopathies, HTLV-I-Associated
Myelopathy caused by Human T-lymphotropic virus 1 (disorder)
Myelopathy caused by Human T-lymphotropic virus 1
MYELOPATHY HUMAN T LYMPHOTROPIC VIRUS TYPE 1 ASSOC
Myelopathy, Htlv 1 Associated
Myelopathy, Htlv-1-Associated
Myelopathy, HTLV-I-Associated
Myelopathy, Human T Lymphotropic Virus Type 1 Associated
Myelopathy, Human T-Lymphotropic Virus Type 1 Associated
Parapareses, Tropical Spastic
Paraparesis, Tropical Spastic [Disease/Finding]
Paraparesis, Tropical Spastic
Paraplegia, Tropical Spastic
Paraplegias, Tropical Spastic
Spastic Parapareses, Tropical
Spastic Paraparesis, Tropical
Spastic Paraplegia, Tropical
Spastic Paraplegias, Tropical
Tropical Spastic Parapareses
Tropical spastic paraparesis (formerly)
tropical spastic paraparesis
Tropical Spastic Paraplegias
Tropical spastic paraplegia
Tropical spastic paresis

External Source Codes:  (none)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH TM UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CTV3ID XUsbj SNOMEDCT_US
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2057-3666 CSP
DID 3130-7431 CSP
DISEASE_IDENTIFIER_ID 295 GARD
DISEASE_IDENTIFIER_ID 296 GARD
DISEASE_IDENTIFIER_ID 297 GARD
DX 19890101 MSH
EFFECTIVE_TIME 20160131 SNOMEDCT_US
HAS_GARD_PAGE true GARD
HN 1989 MSH
IAN DEFAULT ICD10
IDENTIFIER_TYPE_ID 1 GARD
IS_ACTIVE true GARD
IS_RARE true GARD
IS_SPANISH false GARD
MDA 19880610 MSH
MESH_DEFINITION A subacute paralytic myeloneuropathy occurring endemically in tropical areas such as the Caribbean, Colombia, India, and Africa, as well as in the southwestern region of Japan; associated with infection by HUMAN T-CELL LEUKEMIA VIRUS I. Clinical manifestations include a slowly progressive spastic weakness of the legs, increased reflexes, Babinski signs, incontinence, and loss of vibratory and position sensation. On pathologic examination inflammatory, demyelination, and necrotic lesions may be found in the spinal cord. (Adams et al., Principles of Neurology, 6th ed, p1239) NDFRT
MESH_DUI D015493 NDFRT
MESH_NAME Paraparesis, Tropical Spastic NDFRT
MESH_UI M0023855 NDFRT
MIMTYPE 0 OMIM
MIMTYPEMEANING Other, mainly phenotypes with suspected mendelian basis OMIM
MIMTYPEVALUE none OMIM
MMR 20150623 MSH
MN C02.782.815.200.470.710 MSH
MN C10.228.228.618.500 MSH
MN C10.228.854.525.700 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DISEASE_KIND NDFRT
NUI N0000003276 NDFRT
ORDER_NO 05773 ICD10CM
PM 1989 MSH
PRIMARY_PATH 10044696$10038997$10047438$10021881$Tropical spastic paresis$Retroviral infections$Viral infectious disorders$Infections and infestations MDR
PRIMARY_SOC 10021881 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/8208/htlv-1-associated-myelopathytropical-spastic-paraparesis/resources/1 GARD
RXAUI 3169045 RXNORM
RXAUI 3169083 RXNORM
RXAUI 3169084 RXNORM
RXAUI 3173548 RXNORM
RXAUI 3200727 RXNORM
RXAUI 3200738 RXNORM
RXAUI 3218051 RXNORM
RXAUI 3218052 RXNORM
RXAUI 3218071 RXNORM
RXAUI 3250985 RXNORM
RXAUI 5039352 RXNORM
RXAUI 5039664 RXNORM
RXCUI 984370 RXNORM
SNOMED_CID 45129002 NDFRT
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS G04.1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~G04.1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS B97.33 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS G95.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~B97.33 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~G95.9 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUsbj SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T045941 MSH
TERMUI T045942 MSH
TERMUI T045943 MSH
TERMUI T045944 MSH
TERMUI T045945 MSH
TERMUI T369826 MSH
TERMUI T369827 MSH
TERMUI T369828 MSH
TERMUI T369829 MSH
TERMUI T811813 MSH
TERMUI T811814 MSH
TH NLM (1989) MSH
TH NLM (1990) MSH
TH NLM (2000) MSH
TH OMIM (2013) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0030481

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