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Osteosarcoma (CUI C0029463) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0029463

NCI Thesaurus Code: C9145  (see NCI Thesaurus info)

Semantic Type: Neoplastic Process

NCIt Definition: A usually aggressive malignant bone-forming mesenchymal neoplasm, predominantly affecting adolescents and young adults. It usually involves bones and less frequently extraosseous sites. It often involves the long bones (particularly distal femur, proximal tibia, and proximal humerus). Pain with or without a palpable mass is the most frequent clinical symptom. It may spread to other anatomic sites, particularly the lungs.

RADLEX Definition: A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed) [MeSH]

GARD Definition: Osteosarcoma is the most common cancerous (malignant) bone tumor in youth. The average age at diagnosis is 15. Boys and girls have a similar incidence of this tumor until late adolescence, at which time boys are more commonly affected. In rare cases, osteosarcoma occurs in adults. The cause of osteosarcoma is not known. In some cases, it runs in families, and at least one gene has been linked to increased risk. Although osteosarcoma tends to occur in the larger bones, such as the shin (near the knee), thigh (near the knee) and upper arm (near the shoulder), it can occur in any bone. A number of variants of osteosarcoma exist, including conventional types (osteoblastic, chondroblastic, and fibroblastic), telangiectatic, multifocal, parosteal, and periosteal.  Treatment usually starts after a biopsy of the tumor and includes chemotherapy followed by surgery. - this information is from GARD/ORDR/NCATS.

HPO Definition: A malignant bone tumor that usually develops during adolescence and usually affects the long bones including the tibia, femur, and humerus. The typical symptoms of osteosarcoma comprise bone pain, fracture, limitation of motion, and tenderness or swelling at the site of the tumor. [HPO:probinson]

NICHD Definition: A malignant neoplasm of connective tissue origin that produces bone or osteoid.

NCI-GLOSS Definition: A cancer of the bone that usually affects the large bones of the arm or leg. It occurs most commonly in young people and affects more males than females.

CDISC Definition: A malignant neoplasm usually arising from bone.

CTEP Definition: CTEP_For_FDA: 90600096/Osteosarcoma NOS

CSP Definition: malignant primary cancer of bone composed of a connective tissue stroma with evidence of malignant osteoid, bone and/or cartilage formation.

MSH Definition: A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)

Synonyms & Abbreviations: (see Synonym Details)
BONE CANCER, OSTEOGENIC SARCOMA
OSRC
osteochondrosarcoma
Osteogenic sarcoma, NOS
Osteogenic Sarcomas
Osteogenic Sarcoma
osteoid sarcoma
Osteosarcoma [Disease/Finding]
Osteosarcoma NOS
Osteosarcoma Tumors
Osteosarcoma Tumor
OSTEOSARCOMA, MALIGNANT
Osteosarcoma, no ICD-O subtype
Osteosarcoma, no International Classification of Diseases for Oncology subtype (morphologic abnormality)
Osteosarcoma, no International Classification of Diseases for Oncology subtype
Osteosarcoma, NOS
Osteosarcomas
osteosarcoma
Osteosarkom
SARCOMA OSTEOGENIC
Sarcoma, Osteogenic
Sarcomas, Osteogenic
Tumor, Osteosarcoma
Tumors, Osteosarcoma

External Source Codes: 
NCI Thesaurus Code C9145 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN /blood supply /chem /second /secret /ultrastruct permitted; coord IM with BONE NEOPLASMS (IM) or specific precoord bone/neopl term (IM) or specific bone (IM) + BONE NEOPLASMS (IM) MSH
AQL BL BS CF CH CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SC SE SU TH UL UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CODE_REF (C40._, C41._) ICDO
Contributing_Source CDISC NCI
Contributing_Source CTEP NCI
Contributing_Source CTRP NCI
Contributing_Source MedDRA NCI
Contributing_Source NICHD NCI
CTV3ID Xa9AV SNOMEDCT_US
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_LAST_MODIFIED 2012-03-28 PDQ
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2019-1578 CSP
DISEASE_IDENTIFIER_ID 5142 GARD
DX 19890101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
GENELOCUS ,1,3,q,1,4,.,1,-,q,1,4,.,2, OMIM
GENESYMBOL RB1 OMIM
HAS_GARD_PAGE true GARD
HN 89; was SARCOMA, OSTEOGENIC 1963-88 MSH
ICD-O-3_Code 9180/3 NCI
ICD-O-3_CODE 9180/3 SNOMEDCT_US
IDENTIFIER_TYPE_ID 1 GARD
IS_ACTIVE true GARD
IS_RARE true GARD
IS_SPANISH false GARD
MDA 19990101 MSH
MESH_DEFINITION A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed) NDFRT
MESH_DUI D012516 NDFRT
MESH_NAME Osteosarcoma NDFRT
MESH_UI M0019439 NDFRT
MIMTYPE 3 OMIM
MIMTYPEMEANING Phenotype description, molecular basis known. OMIM
MIMTYPEVALUE pound OMIM
MMR 20120703 MSH
MN C04.557.450.565.575.650 MSH
MN C04.557.450.795.620 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
MODULE_ID 731000124108 SNOMEDCT_US
MODULE_NAME US National Library of Medicine maintained module SNOMEDCT_US
NDFRT_KIND DISEASE_KIND NDFRT
Neoplastic_Status Malignant NCI
NICHD_Hierarchy_Term Osteosarcoma NCI
NUI N0000002678 NDFRT
OL use OSTEOSARCOMA to search SARCOMA, OSTEOGENIC 1966-88 MSH
ORIG_STY Neoplasm diagnosis PDQ
PID 49 PDQ
PM 89; was SARCOMA, OSTEOGENIC 1963-88 MSH
PRIMARY_PATH 10031291$10039498$10040778$10029104$Osteosarcoma$Bone sarcomas$Skeletal neoplasms malignant and unspecified$Neoplasms benign, malignant and unspecified (incl cysts and polyps) MDR
PRIMARY_SOC 10029104 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/7284/osteosarcoma/resources/1 GARD
RXAUI 3211029 RXNORM
RXAUI 3211030 RXNORM
RXAUI 3236581 RXNORM
RXAUI 3606153 RXNORM
RXAUI 5039764 RXNORM
RXCUI 1022808 RXNORM
SMQ_TERM_ADDVERSION 10.0 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 20.0 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 21708004 NDFRT
SNOMEDID M-91803 SNOMEDCT_US
SUBSET_MEMBER 446608001~MAPTARGET~9180/3 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~Xa9AV SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~M-91803 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERM_LEVEL 4 ICDO
TERM_LEVEL Synonym ICDO
TERMUI T037138 MSH
TERMUI T037139 MSH
TERMUI T769788 MSH
TERMUI T811802 MSH
TH NLM (1966) MSH
TH NLM (2011) MSH
TH OMIM (2013) MSH
TH ORD (2010) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0029463

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