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Osteoporosis (CUI C0029456) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0029456

NCI Thesaurus Code: C3298  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: A condition of reduced bone mass, with decreased cortical thickness and a decrease in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence. Osteoporosis is classified as primary (Type 1, postmenopausal osteoporosis; Type 2, age-associated osteoporosis; and idiopathic, which can affect juveniles, premenopausal women, and middle-aged men) and secondary osteoporosis (which results from an identifiable cause of bone mass loss).

RADLEX Definition: Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (osteoporosis, postmenopausal) and age-related or senile osteoporosis. [MeSH]

HPO Definition: Osteoporosis is a systemic skeletal disease characterized by low bone density and microarchitectural deterioration of bone tissue with a consequent increase in bone fragility. According to the WHO, osteoporosis is characterized by a value of BMD 2.5 standard deviations or more below the young adult mean. [HPO:curators]

MEDLINEPLUS Definition: 

Osteoporosis makes your bones weak and more likely to break. Anyone can develop osteoporosis, but it is common in older women. As many as half of all women and a quarter of men older than 50 will break a bone due to osteoporosis.

Risk factors include

  • Getting older
  • Being small and thin
  • Having a family history of osteoporosis
  • Taking certain medicines
  • Being a white or Asian woman
  • Having osteopenia, which is low bone density

Osteoporosis is a silent disease. You might not know you have it until you break a bone. A bone mineral density test is the best way to check your bone health. To keep bones strong, eat a diet rich in calcium and vitamin D, exercise and do not smoke. If needed, medicines can also help.

NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

NCI-GLOSS Definition: A condition that is marked by a decrease in bone mass and density, causing bones to become fragile.

CTCAE Definition: A disorder characterized by reduced bone mass, with a decrease in cortical thickness and in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence.

NICHD Definition: Reduced bone mineral density due to decreased number and thickness of bone trabeculae and decreased cortical thickness, associated with increased risk of skeletal fractures. A clinical diagnosis of osteoporosis in childhood requires either a finding of one or more otherwise unexplained vertebral compression fractures, or the presence of bone mineral density Z-score less than or equal to 2.0 accompanied by one or more of the following: 1) at least two long bone fractures by age 10 years; 2) at least three long bone fractures up to age 19 years.

CSP Definition: loss of bone mass and strength due to nutritional, metabolic, or other factors, usually resulting in deformity or fracture; a major public health problem of the elderly, especially women.

MSH Definition: Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.

Synonyms & Abbreviations: (see Synonym Details)
Generalized osteoporosis
OP - Osteoporosis
Osteoporoses
Osteoporosis (disorder)
Osteoporosis [Disease/Finding]
Osteoporosis NOS
Osteoporosis, unspecified
osteoporosis

External Source Codes: 
NCI Thesaurus Code C3298 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN related to aging: note X refs; age-related osteoporosis in men goes here; age-related osteoporosis in women is probably OSTEOPOROSIS, POSTMENOPAUSAL MSH
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
Contributing_Source CTRP NCI
Contributing_Source NICHD NCI
CTV3ID N330. SNOMEDCT_US
DATE_CREATED 10/22/1998 MEDLINEPLUS
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2715-1636 CSP
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EXTERNALLY_DEFINED N LNC
GENELOCUS ,1,1,p,1,2, OMIM
GENESYMBOL BMND8 OMIM
HPO_COMMENT Note, that this class is not equivalent to "generalized osteoporosis", which is a subclass of this class HPO
IAN DEFAULT ICD10
ICA Use additional code to identify major osseous defect, if applicable (731.3); Use additional code to identify personal history of pathologic (healed) fracture (V13.51) ICD9CM
ICE Wedging of vertebra NOS ICD9CM
IPX -M80 ICPC
IPX -M81 ICPC
IPX -M82 ICPC
MDA 19990101 MSH
MESH_DEFINITION Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis. NDFRT
MESH_DUI D010024 NDFRT
MESH_NAME Osteoporosis NDFRT
MESH_UI M0015552 NDFRT
MIMTYPE 3 OMIM
MIMTYPEMEANING Phenotype description, molecular basis known. OMIM
MIMTYPEVALUE pound OMIM
MMR 20151124 MSH
MN C05.116.198.579 MSH
MN C18.452.104.579 MSH
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/osteoporosis.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Arabic https://www.nlm.nih.gov/medlineplus/languages/osteoporosis.html#Arabic MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Chinese - Traditional https://www.nlm.nih.gov/medlineplus/languages/osteoporosis.html#Chinese - Traditional MEDLINEPLUS
MP_OTHER_LANGUAGE_URL French https://www.nlm.nih.gov/medlineplus/languages/osteoporosis.html#French MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Russian https://www.nlm.nih.gov/medlineplus/languages/osteoporosis.html#Russian MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Somali https://www.nlm.nih.gov/medlineplus/languages/osteoporosis.html#Somali MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/osteoporosis.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Institute of Arthritis and Musculoskeletal and Skin Diseases http://www.niams.nih.gov/ MEDLINEPLUS
NCI_THESAURUS_CODE C3298 PDQ
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Osteoporosis NCI
NUI N0000002260 NDFRT
ORIG_STY Secondary related condition PDQ
PID 4691 PDQ
PRIMARY_PATH 10031282$10027425$10005959$10028395$Osteoporosis$Metabolic bone disorders$Bone disorders (excl congenital and fractures)$Musculoskeletal and connective tissue disorders MDR
PRIMARY_SOC 10028395 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RXAUI 3211012 RXNORM
RXAUI 3211013 RXNORM
RXCUI 1022418 RXNORM
SID HP:0002774 HPO
SID HP:0005744 HPO
SMQ_TERM_ADDVERSION 12.1 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 12.1 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 203428004 NDFRT
SNOMED_CID 64859006 NDFRT
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS M81.99 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~M81.99 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS M81.0 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~M81.0 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~N330. SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T029672 MSH
TH POPLINE (1994) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

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