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Bone necrosis (CUI C0029445) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0029445

NCI Thesaurus Code: C34880  (see NCI Thesaurus info)

Semantic Type: Pathologic Function

NCIt Definition: Death of bone tissue due to traumatic or nontraumatic causes.

RADLEX Definition: Death of a bone or part of a bone, either atraumatic or posttraumatic. [MeSH]

MEDLINEPLUS Definition: 

Osteonecrosis is a disease caused by reduced blood flow to bones in the joints. In people with healthy bones, new bone is always replacing old bone. In osteonecrosis, the lack of blood causes the bone to break down faster than the body can make enough new bone. The bone starts to die and may break down.

You can have osteonecrosis in one or several bones. It is most common in the upper leg. Other common sites are your upper arm and your knees, shoulders and ankles. The disease can affect men and women of any age, but it usually strikes in your thirties, forties or fifties.

At first, you might not have any symptoms. As the disease gets worse, you will probably have joint pain that becomes more severe. You may not be able to bend or move the affected joint very well.

No one is sure what causes the disease. Risk factors include

  • Long-term steroid treatment
  • Alcohol abuse
  • Joint injuries
  • Having certain diseases, including arthritis and cancer

Doctors use imaging tests and other tests to diagnose osteonecrosis. Treatments include medicines, using crutches, limiting activities that put weight on the affected joints, electrical stimulation and surgery.

NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

PDQ Definition: Death of bone tissue due to traumatic or nontraumatic causes. Check for active clinical trials using this agent.

NICHD Definition: Death of bone tissue.

CSP Definition: death of a bone or part of a bone, either atraumatic or posttraumatic.

MSH Definition: Death of a bone or part of a bone, either atraumatic or posttraumatic.

Synonyms & Abbreviations: (see Synonym Details)
Bone Necroses
Bone necrosis (disorder)
bone necrosis
Necroses, Bone
NECROSIS BONE
Necrosis of bone NOS
Necrosis of bone
Necrosis, Bone
Osteochondronecrosis
Osteonecroses
Osteonecrosis [Disease/Finding]
Osteonecrosis, unspecified
osteonecrosis
Osteonekrose

External Source Codes: 
NCI Thesaurus Code C34880 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN OSTEORADIONECROSIS & FEMUR HEAD NECROSIS are available MSH
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Contributing_Source CTRP NCI
Contributing_Source MedDRA NCI
Contributing_Source NICHD NCI
CTV3ID X70CH SNOMEDCT_US
DATE_CREATED 05/02/2002 MEDLINEPLUS
DATE_FIRST_PUBLISHED 2015-09-25 PDQ
DATE_LAST_MODIFIED 2015-09-25 PDQ
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DID 2715-1650 CSP
DX 19770101 MSH
EFFECTIVE_TIME 20050131 SNOMEDCT_US
EXCLUDES1 juvenile osteonecrosis (M91-M92) ICD10CM
EXCLUDES1 osteochondropathies (M90-M93) ICD10CM
HN 1977; for KIENBOCK DISEASE, use OSTEOCHONDRITIS 1963-2002 MSH
IAN DEFAULT ICD10
INCLUSION_TERM avascular necrosis of bone ICD10
MDA 19760416 MSH
MESH_DEFINITION Death of a bone or part of a bone, either atraumatic or posttraumatic. NDFRT
MESH_DUI D010020 NDFRT
MESH_NAME Osteonecrosis NDFRT
MESH_UI M0015546 NDFRT
MMR 20160531 MSH
MN C05.116.852 MSH
MN C23.550.717.732 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/osteonecrosis.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/osteonecrosis.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Institute of Arthritis and Musculoskeletal and Skin Diseases http://www.niams.nih.gov/ MEDLINEPLUS
NCI_THESAURUS_CODE C34880 PDQ
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Osteonecrosis NCI
NUI N0000002257 NDFRT
ORDER_NO 22073 ICD10CM
ORDER_NO 22331 ICD10CM
ORIG_STY Secondary related condition PDQ
PM 1977; for KIENBOCK DISEASE, see OSTEOCHONDRITIS 1963-2002 MSH
PRIMARY_PATH 10031264$10027658$10005959$10028395$Osteonecrosis$Bone disorders NEC$Bone disorders (excl congenital and fractures)$Musculoskeletal and connective tissue disorders MDR
PRIMARY_SOC 10028395 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RXAUI 3210991 RXNORM
RXAUI 3210992 RXNORM
RXCUI 1024239 RXNORM
SMQ_TERM_ADDVERSION 13.0 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 13.0 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 240196003 NDFRT
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS M87.99 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~M87.99 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS M87.9 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~M87.9 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~X70CH SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T000898398 MSH
TERMUI T029658 MSH
TH NLM (1977) MSH
TH NLM (2017) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
USE_ADDITIONAL code to identify major osseous defect, if applicable (M89.7-) ICD10CM

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0029445

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