skip navigation links
National Cancer Institute
Enterprise Vocabulary Services
Box
NCIm Version: 201808 (Browser Version 2.9, using LexEVS 6.5.1)
SearchBox Top
SearchBox Bottom
Osteitis Deformans (CUI C0029401) Suggest changes to this concept
Add to Cart

Terms & Properties

Concept Unique Identifier (CUI): C0029401

NCI Thesaurus Code: C3292  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: A disease of bone that initially results in the excessive resorption of bone (by osteoclasts) followed by the replacement of normal bone marrow with vascular and fibrous tissue.

GARD Definition: Paget disease of bone is a disorder that involves abnormal bone destruction and regrowth, which results in deformity. This condition can affect any of the bones in the body; but most people have it in their spine, pelvis, skull, or leg bones. The disease may affect only one bone or several bones; but it does not affect the entire skeleton. Bones with Paget disease may break more easily, and the disease can lead to other health problems. The cause of Paget disease is unknown, although it may be associated with faulty genes or viral infections early in life. - this information is from GARD/ORDR/NCATS.

PDQ Definition: A disease of bone that initially results in the excessive resorption of bone (by osteoclasts) followed by the replacement of normal bone marrow with vascular and fibrous tissue. Check for active clinical trials using this agent. (NCI Thesaurus)

MEDLINEPLUS Definition: 

Paget's disease of bone causes your bones to grow too large and weak. They also might break easily. The disease can lead to other health problems, too, such as arthritis and hearing loss. You can have Paget's disease in any bone, but it is most common in the spine, pelvis, skull, and legs. The disease might affect one or several bones, but not your entire skeleton. More men than women have the disease. It is most common in older people.

No one knows what causes Paget's disease. In some cases, a virus might be responsible. It tends to run in families. Many people do not know they have Paget's disease because their symptoms are mild. For others, symptoms can include

  • Pain
  • Enlarged bones
  • Broken bones
  • Damaged cartilage in joints

Doctors use blood tests and imaging tests to diagnose Paget's disease. Early diagnosis and treatment can prevent some symptoms from getting worse. Treatments include medicines and sometimes surgery. A good diet and exercise might also help.

NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

NCI-GLOSS Definition: A chronic condition in which both the breakdown and regrowth of bone are increased. Paget disease of bone occurs most frequently in the pelvic and leg bones, skull, and lower spine. It is most common in older individuals, and may lead to bone pain, deformities, and fractures.

CSP Definition: disease marked by repeated episodes of increased bone resorption followed by excessive repair, resulting in weakened, deformed bones of increased mass.

MSH Definition: A disease marked by repeated episodes of increased bone resorption followed by excessive attempts at repair, resulting in weakened, deformed bones of increased mass. The resultant architecture of the bone assumes a mosaic pattern in which the fibers take on a haphazard pattern instead of the normal parallel symmetry.

Synonyms & Abbreviations: (see Synonym Details)
Bone Paget Disease
Bone Paget's Disease
Osseous Paget's Disease
Osteitis deformans (disorder)
Osteitis Deformans [Disease/Finding]
Osteitis deformans [Paget's disease of bone]
Osteitis deformans NOS
Osteitis deformans without mention of bone tumor
Osteitis deformans without mention of bone tumour
osteitis deformans
PAGET DIS OF BONE
Paget disease of bone
PAGET DISEASE, BONE
Paget disease
PAGET'S BONE DISEASE
Paget's disease (bone)
Paget's disease of bone [osteitis deformans]
Paget's disease of bone, unspecified
Paget's disease of bone
PAGET'S DISEASE OF THE BONE
Paget's disease
PAGETS DIS OF BONE
Pagets Disease (Bone)
PAGETS DISEASE OF BONE
Pagets Disease, Bone
PDB

External Source Codes: 
NCI Thesaurus Code C3292 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CTV3ID N310. SNOMEDCT_US
DATE_CREATED 03/28/2002 MEDLINEPLUS
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_FIRST_PUBLISHED 2011-01-03 PDQ
DATE_LAST_MODIFIED 2011-01-03 PDQ
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2715-2725 CSP
DISEASE_IDENTIFIER_ID 3190 GARD
DISEASE_IDENTIFIER_ID 3191 GARD
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EXCLUDES1 osteitis deformans in neoplastic disease (M90.6) ICD10CM
HAS_GARD_PAGE true GARD
IAN DEFAULT ICD10
ICE Paget's disease of bone ICD9CM
IDENTIFIER_TYPE_ID 1 GARD
IS_ACTIVE true GARD
IS_RARE false GARD
IS_SPANISH false GARD
LAST_REVIEW_DATE 2009-12-31T00:00:00 GARD
MDA 19990101 MSH
MESH_DEFINITION A disease marked by repeated episodes of increased bone resorption followed by excessive attempts at repair, resulting in weakened, deformed bones of increased mass. The resultant architecture of the bone assumes a mosaic pattern in which the fibers take on a haphazard pattern instead of the normal parallel symmetry. NDFRT
MESH_DUI D010001 NDFRT
MESH_NAME Osteitis Deformans NDFRT
MESH_UI M0015507 NDFRT
MMR 20130708 MSH
MN C05.116.692 MSH
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/pagetsdiseaseofbone.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/pagetsdiseaseofbone.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Institute of Arthritis and Musculoskeletal and Skin Diseases http://www.niams.nih.gov/ MEDLINEPLUS
NCI_THESAURUS_CODE C3292 PDQ
NDFRT_KIND DISEASE_KIND NDFRT
NUI N0000002242 NDFRT
ORDER_NO 22332 ICD10CM
ORIG_STY Disease/diagnosis PDQ
PRIMARY_PATH 10031151$10027658$10005959$10028395$Osteitis deformans$Bone disorders NEC$Bone disorders (excl congenital and fractures)$Musculoskeletal and connective tissue disorders MDR
PRIMARY_SOC 10028395 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/8615/paget-disease-of-bone/resources/1 GARD
RXAUI 3210889 RXNORM
RXAUI 3210890 RXNORM
RXAUI 3217357 RXNORM
RXAUI 3217365 RXNORM
RXAUI 5931857 RXNORM
RXAUI 5931992 RXNORM
RXCUI 1022971 RXNORM
SMQ_TERM_ADDVERSION 12.0 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 14.0 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS I MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 203353000 NDFRT
SNOMED_CID 2089002 NDFRT
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS M88.99 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~M88.99 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS M88.9 | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~M88.9 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~N310. SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T029598 MSH
TERMUI T029599 MSH
TERMUI T029600 MSH
TERMUI T842227 MSH
TERMUI T842228 MSH
TH GHR (2014) MSH
TH NLM (1966) MSH
TH OMIM (2013) MSH
TH ORD (2010) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0029401

Mainbox Bottom