skip navigation links
National Cancer Institute
Enterprise Vocabulary Services
Box
NCIm Version: 201706 Version 2.8 (using LexEVS 6.5)
SearchBox Top
SearchBox Bottom
Norepinephrine (CUI C0028351) Suggest changes to this concept
Add to Cart

Terms & Properties Synonym Details Relationships Sources View All  
Terms & Properties

Concept Unique Identifier (CUI): C0028351

NCI Thesaurus Code: C62098  (see NCI Thesaurus info)

Semantic Type: Hormone

Semantic Type: Organic Chemical

Semantic Type: Pharmacologic Substance

NCIt Definition: A synthetic phenylethylamine that mimics the sympathomimetic actions of the endogenous norepinephrine. Norepinephrine acts directly on the alpha- and beta-adrenergic receptors. Clinically, norepinephrine is used as a peripheral vasoconstrictor that causes constriction of arterial and venous beds via its alpha-adrenergic action. It is also used as a potent inotropic and chronotropic stimulator of the heart mediated through its beta-1 adrenergic action.

NCI-GLOSS Definition: A chemical made by some nerve cells and in the adrenal gland. It can act as both a neurotransmitter (a chemical messenger used by nerve cells) and a hormone (a chemical that travels in the blood and controls the actions of other cells or organs). Noradrenaline is released from the adrenal gland in response to stress and low blood pressure.

MSH Definition: Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.

CSP Definition: precursor of epinephrine; widespread central and autonomic neurotransmitter, principal transmitter of most postganglionic sympathetic fibers; secreted by the adrenal medulla; used pharmacologically as a sympathomimetic.

Synonyms & Abbreviations: (see Synonym Details)
(+/-)-Noradrenaline
(-)-Arterenol
(-)-Noradrenaline
(-)-Norepinephrine
(.+-.)-Noradrenaline
(.+-.)-Norepinephrine
(R)-(-)-Norepinephrine
(R)-4-(2-amino-1-Hydroxyethyl)-1,2-benzenediol
(R)-Norepinephrine
1,2-benzenediol, 4-(2-amino-1-hydroxyethyl)-, (+/-)-
1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-
294898
4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol
51-41-2
Arterenol
L-noradrenaline
L-Norepinephrine
levarterenol
Levonorepinephrine
NA - Noradrenaline
NA - Norepinephrine
Nor-adrenaline
noradrenalin
noradrenaline
NORADRENALINE, (+/-)-
Noradrenaline preparation
Noradrenaline product
Norepinefrina
norepinephrine
NOREPINEPHRINE, DL-
Norepinephrine (substance)
Norepinephrine [Chemical/Ingredient]
Norepinephrine preparation
Norepinephrine preparation (product)
Norepinephrine product
Norepinephrinum

External Source Codes: 
NCI Thesaurus Code C62098 (see NCI Thesaurus info)
CAS Registry Number 138-65-8 (see NLM ChemIDplus info)
FDA UNII Code K294OAI79V
NSC Code 294898 (see NCI DTP info)
PDQ Closed Trial Search ID 691834
PDQ Open Trial Search ID 691834 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BI BL CF CH CL CS CT DF EC GE HI IM IP ME PD PH PK PO RE SD SE ST TO TU UR MSH
AUTHORITY Bloom & Fawcett 94:506; Burt 93:100 FMA
AUTHORITY Gray's 99:936 FMA
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:33569 NCI
Chemical_Formula C8H11NO3 NCI
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID X80FL SNOMEDCT_US
CTV3ID XU2pF SNOMEDCT_US
DATE_FIRST_PUBLISHED 2010-12-22 PDQ
DATE_LAST_MODIFIED 2010-12-22 PDQ
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2268-5994 CSP
DX 19600101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
FDA_UNII_CODE X4W3ENH1CV DRUGBANK
FDA_UNII_CODE X4W3ENH1CV NDFRT
FX D011941 MSH
HN ARTERENOL was see NOREPINEPHRINE 1974-93; LEVONOREPINEPHRINE was heading 1963-65 MSH
LEVEL Ingredient NDFRT
MDA 19990101 MSH
MESH_DEFINITION Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic. NDFRT
MESH_DUI D009638 NDFRT
MESH_NAME Norepinephrine NDFRT
MESH_UI M0014964 NDFRT
MMR 20160701 MSH
MN D02.033.100.291.502 MSH
MN D02.092.063.480 MSH
MN D02.092.211.215.311.560 MSH
MN D02.092.311.461.484 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NCI_THESAURUS_CODE C62098 PDQ
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000007426 NDFRT
NUI N0000147945 NDFRT
OL use NOREPINEPHRINE to search ARTERENOL 1974-93 MSH
ORIG_STY Drug/agent PDQ
PA D000316 MSH
PA D013566 MSH
PA D014662 MSH
PM ARTERENOL was see NOREPINEPHRINE 1974-93; LEVONOREPINEPHRINE was heading 1963-65 MSH
RN X4W3ENH1CV MSH
RR 138-65-8 ((+-)-isomer) MSH
RR 149-95-1 ((+)-isomer) MSH
RR 21368-51-4 (d-tartrate (1:1)) MSH
RR 329-56-6 (HCl) MSH
RR 3414-63-9 ((+-)-isomer, l-tartrate (1:1)) MSH
RR 3458-94-4 ((+)-isomer, HCl) MSH
RR 34888-32-9 (l-tartrate (1:1), mono-H2O) MSH
RR 4W6461XR05 MSH
RR 51-40-1 (l-tartrate (1:1)) MSH
RR 51-41-2 (Norepinephrine) MSH
RR 55-27-6 ((+-)-isomer, HCl) MSH
RR 5794-08-1 ((+)-isomer, l-tartrate (1:1), mono-H2O) MSH
RR 586-17-4 (cpd without isomeric designation) MSH
RR 636-88-4 ((+)-isomer, l-tartrate (1:1)) MSH
RR 71827-07-1 (l-tartrate (1:2)) MSH
RR IFY5PE3ZRW MSH
RXAUI 2072569 RXNORM
RXAUI 243301 RXNORM
RXAUI 3091070 RXNORM
RXAUI 3189347 RXNORM
RXAUI 3189370 RXNORM
RXAUI 3203712 RXNORM
RXAUI 3203713 RXNORM
RXAUI 3207540 RXNORM
RXAUI 3207567 RXNORM
RXAUI 3207589 RXNORM
RXAUI 3632073 RXNORM
RXAUI 4618345 RXNORM
RXAUI 7251794 RXNORM
RXAUI 7251888 RXNORM
RXCUI 1657875 RXNORM
RXCUI 7512 RXNORM
SID APRD01299 DRUGBANK
SNOMEDID C-680D0 SNOMEDCT_US
SNOMEDID F-B2120 SNOMEDCT_US
SPL_SET_ID 0012578b-66ff-49a8-8415-693c68ab9c16 MTHSPL
SPL_SET_ID 0735b8c0-fd9c-4154-9a08-8c2d2200ec93 MTHSPL
SPL_SET_ID 0b8896b6-b8ac-4d04-9d5f-60c21404e159 MTHSPL
SPL_SET_ID 0b94f4c6-7907-4162-ab8f-15e881adcfa5 MTHSPL
SPL_SET_ID 10007c6a-1e22-4221-bde7-ff8e63ab9adc MTHSPL
SPL_SET_ID 1093e746-cb28-4537-becb-b84670b88309 MTHSPL
SPL_SET_ID 1228bfab-6e51-4295-8194-5f2b395d62d2 MTHSPL
SPL_SET_ID 160afc8d-b485-41ac-97ad-96f567ace387 MTHSPL
SPL_SET_ID 19aa6ca2-66e9-42e7-91e4-93220da84a08 MTHSPL
SPL_SET_ID 1d5238c4-3974-4cac-b77c-452e6dcff9de MTHSPL
SPL_SET_ID 2801988f-18a8-491b-b7fd-132dedc3e4c6 MTHSPL
SPL_SET_ID 28f82bb6-1769-490d-ba28-2b382b6e6aca MTHSPL
SPL_SET_ID 2ba1f768-ccc7-41d0-8039-ccb81931fedd MTHSPL
SPL_SET_ID 2bf86a71-0ee2-4801-8cdd-e79907d3e020 MTHSPL
SPL_SET_ID 2e0570e7-d28f-4936-cba8-81ee0c4c3547 MTHSPL
SPL_SET_ID 3352c7d0-e621-46ed-9a54-e4a9583cde10 MTHSPL
SPL_SET_ID 33c0a5ad-3a7a-44c3-862d-288f4a7bc5c4 MTHSPL
SPL_SET_ID 350f76f7-a6de-48b9-a09a-847ba4041180 MTHSPL
SPL_SET_ID 3af34476-26df-8ecd-2198-40b6ee5708b0 MTHSPL
SPL_SET_ID 40fd45b4-d955-4fea-b891-32eae19ab25e MTHSPL
SPL_SET_ID 4533d8c9-b35c-4753-bb72-ba4fffd0f1a9 MTHSPL
SPL_SET_ID 49f31fe2-bb1f-4596-b748-86ae0567c261 MTHSPL
SPL_SET_ID 4d3531fb-82a4-41ab-8c36-eb0aace61f5c MTHSPL
SPL_SET_ID 521b3175-d997-494f-9722-74246fe4f55d MTHSPL
SPL_SET_ID 576e3499-260b-4cc9-87c8-b54375719dd3 MTHSPL
SPL_SET_ID 57c8ec91-5103-4e6f-a678-efa4d55145ae MTHSPL
SPL_SET_ID 59a111c0-b728-4f33-8528-4cb09ecf5ae3 MTHSPL
SPL_SET_ID 5c8f36b2-aec3-442a-bc13-d454a0de252b MTHSPL
SPL_SET_ID 697aedf6-c414-432a-9303-87e824e31d61 MTHSPL
SPL_SET_ID 6e77a40c-6c9d-44ed-8a62-1b3a508a69dc MTHSPL
SPL_SET_ID 70251489-1511-485e-bb95-6eaac218c27b MTHSPL
SPL_SET_ID 71f901b5-022b-43ea-b1a0-29adc9a1f718 MTHSPL
SPL_SET_ID 74bdd5ad-0f93-4f2e-87a1-960d68458314 MTHSPL
SPL_SET_ID 7665d5a4-06d5-4d78-b7a9-481512b8a5ef MTHSPL
SPL_SET_ID 77da899e-fa5b-476c-a7b3-5fa635e5ea4c MTHSPL
SPL_SET_ID 82badddc-47b3-4779-af64-a0e08bc4dee9 MTHSPL
SPL_SET_ID 89ef0203-5cb0-4c18-bfa4-e23e4f52d812 MTHSPL
SPL_SET_ID 8c9dc6eb-e53a-4cc0-92c3-7a53d268cf93 MTHSPL
SPL_SET_ID 91916d24-940c-4f6c-85ef-f1524f1db5c7 MTHSPL
SPL_SET_ID 9531bf7b-85fe-4d82-9ef8-e10eab82a7a2 MTHSPL
SPL_SET_ID 971d503f-217b-4c35-88d0-790c1eb89447 MTHSPL
SPL_SET_ID 997f00c2-affb-4af1-bdff-7ceb418df696 MTHSPL
SPL_SET_ID a27fb6e0-8f7a-11db-9739-0050c2490048 MTHSPL
SPL_SET_ID b3abed0f-4d8c-42b5-8b28-f7bfb3fcb0eb MTHSPL
SPL_SET_ID b6637f00-3660-4fc5-acbd-4f1dfb02e80d MTHSPL
SPL_SET_ID b9f61ca1-e9f7-4e3b-9039-a6585c4e5bb3 MTHSPL
SPL_SET_ID bb5e8d16-303f-49fc-8424-d57ce41b588d MTHSPL
SPL_SET_ID bd9698e8-1f5e-4881-8b58-beb6b632198e MTHSPL
SPL_SET_ID c4de72a8-2a75-4984-ce90-e4870226dc12 MTHSPL
SPL_SET_ID ca3c681c-5e5b-34d0-5917-549529afa65d MTHSPL
SPL_SET_ID d1bbc5b7-984b-46c9-89f7-e97942f79b3e MTHSPL
SPL_SET_ID d2b5320e-e6a6-4a43-8f3c-9c21195ceb4a MTHSPL
SPL_SET_ID d65fb844-183c-462f-a4ce-200ca5fe0803 MTHSPL
SPL_SET_ID dd6b7ad0-0dca-40a0-9b38-5856f1893281 MTHSPL
SPL_SET_ID e66d3794-3395-45e6-901f-21e26ad42a2e MTHSPL
SPL_SET_ID e82e3fb5-65f8-415f-bc98-3f9cf3111164 MTHSPL
SPL_SET_ID e96ed884-239a-4676-aa3c-a472d8e23a61 MTHSPL
SPL_SET_ID edf75607-d285-45e5-912e-280d13acbc2b MTHSPL
SPL_SET_ID f075a58f-2977-44b4-838d-a24ae0bc550c MTHSPL
SPL_SET_ID f13a92ec-bb94-4ebd-acaa-b9ad14d67cac MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~X80FL SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XU2pF SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~C-680D0 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~F-B2120 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T028673 MSH
TERMUI T028674 MSH
TERMUI T028675 MSH
TERMUI T028676 MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
UWT Anatomical Structure UWDA
VANDF_RECORD 50.416^2482^Active/Master NDFRT
VANDF_RECORD 50.6^545^Active/Master NDFRT
VUID 4019859 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0028351

Mainbox Bottom