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Niacin (CUI C0027996) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0027996

NCI Thesaurus Code: C689  (see NCI Thesaurus info)

Semantic Type: Vitamin

Semantic Type: Pharmacologic Substance

NCIt Definition: A water-soluble vitamin belonging to the vitamin B family, which occurs in many animal and plant tissues, with antihyperlipidemic activity. Niacin is converted to its active form niacinamide, which is a component of the coenzymes nicotinamide adenine dinucleotide (NAD) and its phosphate form, NADP. These coenzymes play an important role in tissue respiration and in glycogen, lipid, amino acid, protein, and purine metabolism. Although the exact mechanism of action by which niacin lowers cholesterol is not fully understood, it may act by inhibiting the synthesis of very low density lipoproteins (VLDL), inhibiting the release of free fatty acids from adipose tissue, increasing lipoprotein lipase activity, and reducing the hepatic synthesis of VLDL-C and LDL-C.

PDQ Definition: A water-soluble vitamin belonging to the vitamin B family, which occurs in many animal and plant tissues, with antihyperlipidemic activity. Niacin is converted to its active form niacinamide, which is a component of the coenzymes nicotinamide adenine dinucleotide (NAD) and its phosphate form, NADP. These coenzymes play an important role in tissue respiration and in glycogen, lipid, amino acid, protein, and purine metabolism. Although the exact mechanism of action by which niacin lowers cholesterol is not fully understood, it may act by inhibiting the synthesis of very low density lipoproteins (VLDL), inhibiting the release of free fatty acids from adipose tissue, increasing lipoprotein lipase activity, and reducing the hepatic synthesis of VLDL-C and LDL-C. Check for active clinical trials using this agent. (NCI Thesaurus)

NCI-GLOSS Definition: A nutrient in the vitamin B complex that the body needs in small amounts to function and stay healthy. Niacin helps some enzymes work properly and helps skin, nerves, and the digestive tract stay healthy. Niacin is found in many plant and animal products. It is water-soluble (can dissolve in water) and must be taken in every day. Not enough niacin can cause a disease called pellagra (a condition marked by skin, nerve, and digestive disorders). A form of niacin is being studied in the prevention of skin and other types of cancer. Niacin may help to lower blood cholesterol.

CRCH Definition: Water-soluble vitamin that is a cosubstrate or coenzyme with numerous dehydrogenases for the transfer of the hydride ion. (DRI)

CSP Definition: nicotinic acid (3-pyridinecarboxylic acid) and its derivatives; a water soluble B vitamin which is the precursor of NAD and NADP.

MSH Definition: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.

Synonyms & Abbreviations: (see Synonym Details)
169454
3 Pyridinecarboxylic Acid
3-carboxypyridine
3-Pyridinecarboxylic acid
3-Pyridylcarboxylic acid
59-67-6
[VT103] NICOTINIC ACID
Acide Nicotinique
Acido nicotinico
Acidum Nicotinicum
Anti-pellagra vitamin
Antipellagra factor
beta-Pyridinecarboxylic acid
M-Pyridinecarboxylic Acid
Niacin [Chemical/Ingredient]
Niacin preparation
niacin
Nicotinamide
Nicotinic acid (substance)
Nicotinic Acid Amide
Nicotinic Acid
Nikotinsaeure
P.P. factor
Pellagra preventive factor
PP Factor
Product containing nicotinic acid (medicinal product)
Product containing nicotinic acid
Pyridine-beta-carboxylic acid
pyridine-β-carboxylic acid
Vitamin B-3
Vitamin B3
β-pyridinecarboxylic acid

External Source Codes: 
NCI Thesaurus Code C689 (see NCI Thesaurus info)
CAS Registry Number 59-67-6 (see NLM ChemIDplus info)
FDA UNII Code 2679MF687A
NSC Code 169454 (see NCI DTP info)
PDQ Closed Trial Search ID 38351
PDQ Open Trial Search ID 38351 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN /defic: consider also PELLAGRA; /ther use: coordinate with disease term with either /drug ther or /diet ther depending on whether niacin is discussed as a drug or a dietary supplement MSH
AQL AA AD AE AG AI AN BI BL CF CH CL CS CT DF EC GE HI IM IP ME PD PH PK PO RE SD SE ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:15940 NCI
Chemical_Formula C6H5NO2 NCI
Contributing_Source CRCH NCI
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID bx8.. SNOMEDCT_US
CTV3ID XM0l0 SNOMEDCT_US
DATE_LAST_MODIFIED 2008-09-22 PDQ
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 3147-2013 CSP
DRUG_CLASS_TYPE 2 VANDF
DX 19830101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
FDA_UNII_CODE 2679MF687A DRUGBANK
FDA_UNII_CODE 2679MF687A NDFRT
HN 83; was see NICOTINIC ACIDS 1975-82 & NICOTINIC ACID 1963-74 MSH
INFOODS NIA NCI
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
LEVEL VA Class NDFRT
MDA 19820506 MSH
MESH_DEFINITION A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties. NDFRT
MESH_DUI D009525 NDFRT
MESH_NAME Niacin NDFRT
MESH_UI M0014807 NDFRT
Micronutrient Y NCI
MMR 20160531 MSH
MN D03.066.515.475 MSH
MN D03.383.725.547.475 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NCI_THESAURUS_CODE C689 PDQ
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006449 NDFRT
NUI N0000029451 NDFRT
NUI N0000146039 NDFRT
NUI N0000147570 NDFRT
Nutrient Y NCI
OL search NICOTINIC ACIDS 1966-82 MSH
ORIG_STY Drug/agent PDQ
PA D000960 MSH
PA D014665 MSH
PA D014803 MSH
PARENT_CLASS 427 VANDF
PID 1097 PDQ
PM 83; was see NICOTINIC ACIDS 1975-82 & NICOTINIC ACID 1963-74 MSH
RN 2679MF687A MSH
RR 10361-13-4 (Fe(2+) salt) MSH
RR 128758-69-0 (Li salt, hemi-H20) MSH
RR 16518-17-5 (K salt) MSH
RR 1976-28-9 (Al salt) MSH
RR 28029-53-0 (Co(2+) salt) MSH
RR 28029-54-1 (Mn(2+) salt) MSH
RR 30827-46-4 (Cu(2+) salt) MSH
RR 36321-41-2 (NH4 salt) MSH
RR 3789-96-6 (tartrate) MSH
RR 51914-60-4 (Zn salt) MSH
RR 53890-72-5 (Li salt) MSH
RR 54-86-4 (Na salt) MSH
RR 59-67-6 MSH
RR 636-79-3 (HCl) MSH
RR 7069-06-9 (Mg salt) MSH
RR 823-77-8 (Ca salt) MSH
RR 99148-57-9 (tosylate) MSH
RXAUI 2072519 RXNORM
RXAUI 2072535 RXNORM
RXAUI 2595289 RXNORM
RXAUI 2628791 RXNORM
RXAUI 2629780 RXNORM
RXAUI 2969520 RXNORM
RXAUI 3093303 RXNORM
RXAUI 3093304 RXNORM
RXAUI 3202749 RXNORM
RXAUI 3202750 RXNORM
RXAUI 3203013 RXNORM
RXAUI 3203014 RXNORM
RXAUI 3203015 RXNORM
RXAUI 3206840 RXNORM
RXAUI 3206841 RXNORM
RXAUI 3206906 RXNORM
RXAUI 3257950 RXNORM
RXAUI 3722901 RXNORM
RXCUI 1551658 RXNORM
RXCUI 7393 RXNORM
SID APRD00536 DRUGBANK
SID NUTR00042 DRUGBANK
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SPL_SET_ID e351c4f3-af84-44e2-b04d-d7628088105b MTHSPL
SPL_SET_ID e65ad789-6e09-4c29-9e6c-bc26c892c98e MTHSPL
SPL_SET_ID e6e6b4c6-5d1f-4cd8-9dd5-db184b64d98e MTHSPL
SPL_SET_ID e700dc6e-e7ae-47ee-9974-430bfd045b4f MTHSPL
SPL_SET_ID e80aadb4-0533-4887-8dbb-a75f0c739942 MTHSPL
SPL_SET_ID eac1abb4-58bf-4cd0-aa66-a93e116f516c MTHSPL
SPL_SET_ID eb67ee2f-a71b-4c76-a0b8-c7e904061003 MTHSPL
SPL_SET_ID eba71a0a-cefc-47d3-87ea-74ffea8dea6c MTHSPL
SPL_SET_ID ec145460-3b21-4c6f-abd3-8764bd624417 MTHSPL
SPL_SET_ID ed793721-e869-43de-9d6e-6dc9c8230e36 MTHSPL
SPL_SET_ID ee94954f-ec49-4a10-8af9-c667603cefce MTHSPL
SPL_SET_ID ef22b808-7bcc-413a-925a-4dc1f70f36a9 MTHSPL
SPL_SET_ID f02b9e2f-426a-45e8-b98f-a6f382f9a28e MTHSPL
SPL_SET_ID f2b02ab6-0d90-4a2e-87d4-06e65f27d9f6 MTHSPL
SPL_SET_ID f3a46fb0-5f62-49b6-b228-9bde6206a669 MTHSPL
SPL_SET_ID f5c6a7a2-ec5a-43b0-b819-263ebad66cfe MTHSPL
SPL_SET_ID f74db588-313c-4eec-8c9d-9ff9455c9fa6 MTHSPL
SPL_SET_ID f9b97613-c62e-40b0-a2aa-a7fde6bd5bc7 MTHSPL
SPL_SET_ID fadfbb61-6c66-4fcb-80c4-0fb35ae9978b MTHSPL
SPL_SET_ID fbe83466-aaea-49ab-9f00-4ff6e0930c44 MTHSPL
SPL_SET_ID fc312806-1441-478d-95a2-68ce9a7a796d MTHSPL
SPL_SET_ID fe10912e-00e3-406c-a80c-d9c991dc9f8b MTHSPL
SPL_SET_ID fee71618-533b-41c8-bbdd-0a7ff68509b8 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~bx8.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XM0l0 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T028358 MSH
TERMUI T028359 MSH
TERMUI T028360 MSH
TH BAN (19XX) MSH
TH FDA SRS (2015) MSH
TH INN (19XX) MSH
TH POPLINE (1984) MSH
TH UNK (19XX) MSH
TH USAN (19XX) MSH
TH USP (19XX) MSH
Tolerable_Level Y NCI
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
Unit mg NCI
US_Recommended_Intake Y NCI
USDA_ID 406 NCI
VAC VT103 NDFRT
VAC VT103 VANDF
VANDF_RECORD 50.416^2054^Active/Master NDFRT
VANDF_RECORD 50.416^256^Active/Master NDFRT
VANDF_RECORD 50.605^421^Active/Master NDFRT
VANDF_RECORD 50.6^1080^Active/Master NDFRT
VUID 4017661 NDFRT
VUID 4019440 NDFRT
VUID 4021898 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0027996

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