|Terms & Properties|
Concept Unique Identifier (CUI): C0027836
NCI Thesaurus Code: C12615 (see NCI Thesaurus info)
Semantic Type: Cell
NCIt Definition: A non-neuronal cell of the nervous system. Glial cells have diverse roles, including in regulation of neuronal survival and differentiation, maintenance of ion and neurotransmitter concentrations in the neuronal environment, synapse formation, and support of synaptic interactions and electrical signal propagation.
NCI-GLOSS Definition: Any of the cells that hold nerve cells in place and help them work the way they should. The types of neuroglia include oligodendrocytes, astrocytes, microglia, and ependymal cells.
CSP Definition: non-neuronal cells of the nervous system; they provide physical support, respond to injury, regulate the ionic and chemical composition of the extracellular milieu, form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons.
MSH Definition: The non-neuronal cells of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu, participate in the BLOOD-BRAIN BARRIER and BLOOD-RETINAL BARRIER, form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear.
Synonyms & Abbreviations: (see Synonym Details)
|Glia (body structure)|
|Glial cell (cell)|
|Neuroglial cells set|
|Set of glial cells|
|Set of neuroglial cells|
External Source Codes:
|NCI Thesaurus Code||C12615 (see NCI Thesaurus info)|
|AQL||CH CL CY DE EN IM ME MI PA PH PS RE SE TR UL VI||MSH|
|AUTHORITY||Bloom & Fawcett 1975||FMA|
|AUTHORITY||Bloom & Fawcett 94: 355||FMA|
|AUTHORITY||Gray's 99: 937||FMA|
|AUTHORITY||Terminologia Anatomica 1998||FMA|
|DATE_LAST_MODIFIED||Fri Jun 09 10:51:56 PDT 2000||FMA|
|DATE_LAST_MODIFIED||Fri Jun 09 11:04:21 PDT 2000||FMA|
|DATE_LAST_MODIFIED||Fri Jun 09 11:32:48 PDT 2000||FMA|
|DATE_LAST_MODIFIED||Fri Jun 09 15:56:38 PDT 2000||FMA|
|DATE_LAST_MODIFIED||Fri Jun 09 15:57:10 PDT 2000||FMA|
|SOS||Collectively, the non-neuronal cellular components of the central nervous system that, together with the fine tissue web that they generate, make up the structural and functional support system of the brain and spinal cord. Neuroglial cells are usually divided into two major categories, macroglia and microglia. The macroglia consists of astrocytes and oligodendrocytes (oligodendroglia), which are of ectodermal origin. Astrocytes may be of protoplasmic or fibrillary type, the latter developing particularly in later life or in response to neural tissue injury. Oligodendrocytes frequently surround neurons closely as satellite cells or lie among the myelinated axon bundles as interfascicular oligodendroglia. All of these types may be involved in the control of the ionic and molecular medium and in the synthesis of important neurally active materials. Interfascicular oligoglia are also concerned with the formation and maintenance of myelin. The microglia, of mesodermal origin, are believed to be derived from blood vessels, and they form wandering phagocytes.||AOD|
Additional Concept Data: (none)