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Neuroblastoma (CUI C0027819) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0027819

NCI Thesaurus Code: C3270  (see NCI Thesaurus info)

Semantic Type: Neoplastic Process

NCIt Definition: A neuroblastic tumor characterized by the presence of neuroblastic cells, the absence of ganglion cells, and the absence of a prominent Schwannian stroma formation.

RADLEX Definition: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51) [MeSH]

GARD Definition: Neuroblastoma is a tumor that develops from a nerve in a child, usually before the age of 5.  It occurs in the abdomen near the adrenal glands, but it can also occur in other parts of the body.  It is considered an aggressive tumor because it often spreads to other parts of the body (metastasizes).   The symptoms of a neuroblastoma may include a lump in the abdomen, pain, diarrhea, or generally feeling unwell.  It affects one out of 100,000 children.   The exact cause of this tumor is not yet known.  Neuroblastoma may be diagnosed by physical examination; specific blood tests; imaging tests such as x-rays, magnetic resonance imaging (MRI), or computed tomography (CT) scans; and a biopsy.   Treatment depends on the size and location of the tumor within the body, as well as the child's age. Surgery is often the first step of treatment, and may be followed by chemotherapy, radiation therapy, or a stem cell transplant in more severe cases. - this information is from GARD/ORDR/NCATS.

HPO Definition: Neuroblastoma is a solid tumor that originate in neural crest cells of the sympathetic nervous system. Most neuroblastomas originate in the abdomen, and most abdominal neuroblastomas originate in the adrenal gland. Neuroblastomas can also originate in the thorax, usually in the posterior mediastinum. [HPO:probinson]

MEDLINEPLUS Definition: 

Neuroblastoma is a cancer that forms in your nerve tissue. It usually begins in the adrenal glands, which sit atop your kidneys. It may also begin in your neck, chest or spinal cord. The cancer often begins in early childhood. Sometimes it begins before a child is born. By the time doctors find the cancer, it has usually spread to other parts of the body. The most common symptoms are

  • A lump in the abdomen, neck or chest
  • Bulging eyes
  • Dark circles around the eyes
  • Bone pain
  • Swollen stomach and trouble breathing in babies
  • Painless, bluish lumps under the skin in babies
  • Inability to move a body part

Treatments include surgery, radiation therapy, chemotherapy, biologic therapy, or a combination. Biologic therapy boosts your body's own ability to fight cancer. Sometimes before giving treatment, doctors wait to see whether symptoms get worse. This is called watchful waiting.

NIH: National Cancer Institute

CDISC Definition: A malignant neoplasm composed of neuroblastic cells.

NICHD Definition: A malignant neoplasm comprised of neuroblasts that commonly arises in or near the adrenal glands.

NCI-GLOSS Definition: Cancer that arises in immature nerve cells and affects mostly infants and children.

CSP Definition: common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death; histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa; the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system.

MSH Definition: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)

Synonyms & Abbreviations: (see Synonym Details)
Central neuroblastoma
NB - Neuroblastoma
NB
Neural Crest Tumor, Malignant
Neuroblastoma (disorder)
Neuroblastoma (morphologic abnormality)
Neuroblastoma (Schwannian Stroma-poor)
Neuroblastoma [Disease/Finding]
Neuroblastoma NOS
NEUROBLASTOMA, MALIGNANT
Neuroblastoma, NOS
Neuroblastomas
neuroblastoma
Neuroblastom
Schwannian stroma-poor peripheral neuroblastic neoplasm

External Source Codes: 
NCI Thesaurus Code C3270 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN coord IM with precoord organ/neopl term (IM); for NEUROBLASTOMA, RETINAL see RETINOBLASTOMA MSH
AQL BL BS CF CH CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SC SE SU TH UL UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CODE_REF (C71._) ICDO
Contributing_Source CDISC NCI
Contributing_Source CTEP NCI
Contributing_Source CTRP NCI
Contributing_Source MedDRA NCI
Contributing_Source NICHD NCI
CTV3ID Xa99D SNOMEDCT_US
CTV3ID XUgvc SNOMEDCT_US
DATE_CREATED 07/18/2000 MEDLINEPLUS
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_LAST_MODIFIED 2012-03-27 PDQ
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2012-7126 CSP
DISEASE_IDENTIFIER_ID 4979 GARD
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20080731 SNOMEDCT_US
HAS_GARD_PAGE true GARD
ICD-O-3_Code 9500/3 NCI
ICD-O-3_CODE 9500/3 SNOMEDCT_US
IDENTIFIER_TYPE_ID 1 GARD
IS_ACTIVE true GARD
IS_RARE true GARD
IS_SPANISH false GARD
MDA 19990101 MSH
MESH_DEFINITION A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51) NDFRT
MESH_DUI D009447 NDFRT
MESH_NAME Neuroblastoma NDFRT
MESH_UI M0014699 NDFRT
MMR 20130708 MSH
MN C04.557.465.625.600.590.650.550 MSH
MN C04.557.470.670.590.650.550 MSH
MN C04.557.580.625.600.590.650.550 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/neuroblastoma.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/neuroblastoma.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Cancer Institute http://www.nci.nih.gov/ MEDLINEPLUS
NDFRT_KIND DISEASE_KIND NDFRT
Neoplastic_Status Malignant NCI
NICHD_Hierarchy_Term Neuroblastoma NCI
NUI N0000002167 NDFRT
ORIG_STY Neoplasm diagnosis PDQ
PID 530 PDQ
PRIMARY_PATH 10029260$10029212$10029211$10029104$Neuroblastoma$Nervous system neoplasms malignant NEC$Nervous system neoplasms malignant and unspecified NEC$Neoplasms benign, malignant and unspecified (incl cysts and polyps) MDR
PRIMARY_SOC 10029104 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/7185/neuroblastoma/resources/1 GARD
RXAUI 3206048 RXNORM
RXAUI 3206049 RXNORM
RXCUI 1026096 RXNORM
SID HP:0006738 HPO
SMQ_TERM_ADDVERSION 10.0 MDR
SMQ_TERM_ADDVERSION 14.0 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 14.0 MDR
SMQ_TERM_LMVERSION 20.0 MDR
SMQ_TERM_SCOPE 1 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 87364003 NDFRT
SUBSET_MEMBER 446608001~MAPTARGET~9500/3 SNOMEDCT_US
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS C74.9 | POSSIBLE REQUIREMENT FOR MORPHOLOGY CODE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~C74.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS C74.90 | CONSIDER LATERALITY SPECIFICATION SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF ABDOMINOTHORACIC NEUROBLASTOMA CHOOSE C76.8 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF METASTATIC NEUROBLASTOMA CHOOSE C79.9 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF METASTATIC NEUROBLASTOMA OF ORBIT PROPER CHOOSE C79.49 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF NEUROBLASTOMA OF BRAIN CHOOSE C71.9 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF NEUROBLASTOMA OF CENTRAL NERVOUS SYSTEM CHOOSE C72.9 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF PARASPINAL NEUROBLASTOMA CHOOSE C75.5 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF PELVIC NEUROBLASTOMA CHOOSE C76.3 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF THORACIC NEUROBLASTOMA CHOOSE C76.1 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447639009 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~4 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~5 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~6 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~7 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~8 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 281560004 | Neuroblastoma of brain | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 281563002 | Thoracic neuroblastoma | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 281564008 | Pelvic neuroblastoma | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 281565009 | Paraspinal neuroblastoma | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 281566005 | Abdominothoracic neuroblastoma | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 414676007 | Metastatic neuroblastoma of orbit proper | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 704152002 | Metastatic neuroblastoma | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 734099007 | Neuroblastoma of central nervous system | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~OTHERWISE TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~C71.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~C72.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~C74.90 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~C75.5 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~C76.1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~C76.3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~C76.8 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~C79.49 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~C79.9 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~Xa99D SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUgvc SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERM_LEVEL 4 ICDO
TERM_LEVEL Synonym ICDO
TERMUI T028158 MSH
TH GHR (2014) MSH
TH NLM (1966) MSH
TH ORD (2010) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0027819

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