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Nephrotic Syndrome (CUI C0027726) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0027726

NCI Thesaurus Code: C34845  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: A collection of symptoms that include severe edema, proteinuria, and hypoalbuminemia; it is indicative of renal dysfunction.

HPO Definition: Nephrotic syndrome is a collection of findings resulting from glomerular dysfunction with an increase in glomerular capillary wall permeability associated with pronounced proteinuria. Nephrotic syndrome refers to the constellation of clinical findings that result from severe renal loss of protein, with Proteinuria and hypoalbuminemia, edema, and hyperlipidemia. [HPO:probinson]

NICHD Definition: A syndrome characterized by proteinuria, hypoalbuminemia, and varying degrees of edema, and possibly hypercholesteremia.

CSP Definition: diseases involving defective kidney glomeruli, characterized by massive proteinuria and lipiduria with varying degrees of edema, hypoalbuminemia, and hyperlipidemia.

MSH Definition: A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in the urine results in complications such as HYPOPROTEINEMIA; generalized EDEMA; HYPERTENSION; and HYPERLIPIDEMIAS. Diseases associated with nephrotic syndrome generally cause chronic kidney dysfunction.

Synonyms & Abbreviations: (see Synonym Details)
-- Nephrotic Syndrome
Nephrosis
Nephrotic syndrome (disorder)
Nephrotic Syndrome [Disease/Finding]
Nephrotic syndrome; Unspecified
Nephrotic Syndromes
nephrotic syndrome
NS - Nephrotic syndrome
SYNDROME NEPHROTIC
Syndrome, Nephrotic
Syndromes, Nephrotic

External Source Codes: 
NCI Thesaurus Code C34845 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Contributing_Source NICHD NCI
CTV3ID K01.. SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 1682-1943 CSP
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EXTERNALLY_DEFINED N LNC
HN Introduced 2000. AOD
HPO_COMMENT In adults, nephrotic syndrome is characterized by protein excretion of 3.5 g or more per day. In children, nephrotic syndrome is accompanied by protein excretion of more than 40 mg/m2/h. HPO
IAN DEFAULT ICD10
INCLUSION_TERM congenital nephrotic syndrome ICD10
INCLUSION_TERM lipoid nephrosis ICD10
MDA 19990101 MSH
MESH_DEFINITION A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in the urine results in complications such as HYPOPROTEINEMIA; generalized EDEMA; HYPERTENSION; and HYPERLIPIDEMIAS. Diseases associated with nephrotic syndrome generally cause chronic kidney dysfunction. NDFRT
MESH_DUI D009404 NDFRT
MESH_NAME Nephrotic Syndrome NDFRT
MESH_UI M0014639 NDFRT
MMR 20060707 MSH
MN C12.777.419.630.643 MSH
MN C13.351.968.419.630.643 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Nephrotic Syndrome NCI
NUI N0000002155 NDFRT
ORDER_NO 23245 ICD10CM
PRIMARY_PATH 10029164$10018365$10029149$10038359$Nephrotic syndrome$Glomerulonephritis and nephrotic syndrome$Nephropathies$Renal and urinary disorders MDR
PRIMARY_SOC 10038359 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RXAUI 3205642 RXNORM
RXAUI 3205643 RXNORM
RXCUI 1026285 RXNORM
SID HP:0000801 HPO
SID HP:0004718 HPO
SID HP:0008638 HPO
SID HP:0008727 HPO
SMQ_TERM_ADDVERSION 16.0 MDR
SMQ_TERM_ADDVERSION 17.1 MDR
SMQ_TERM_ADDVERSION 19.0 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_CAT B MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 16.0 MDR
SMQ_TERM_LMVERSION 17.1 MDR
SMQ_TERM_LMVERSION 19.0 MDR
SMQ_TERM_SCOPE 1 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 52254009 NDFRT
SNOMEDID D7-11280 SNOMEDCT_US
SOS An abnormal condition of the kidney, characterized by marked proteinura, hypoalbuminemia, and edema. It occurs in glomerrular disease and thrombosis of a renal vein, and as a complication of many systemic diseases, diabetes mellitus, amyloidosis, etc. AOD
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS N04.9 | POSSIBLE REQUIREMENT FOR AN EXTERNAL CAUSE CODE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~N04.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS N04.9 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~N04.9 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~K01.. SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~D7-11280 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T028053 MSH
TH NLM (1963) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0027726

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