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Multiple Sclerosis (CUI C0026769) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0026769

NCI Thesaurus Code: C3243  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers.

GARD Definition: Multiple sclerosis (MS) is a disorder that affects the central nervous system (CNS), specifically the brain and spinal cord. A fatty tissue called myelin surrounds and protects the nerve fibers of the CNS. Myelin insulates the nerves and allows them to transmit electrical impulses from the brain to other parts of the body. In MS, myelin is lost in multiple areas, and sometimes the nerve fiber itself is damaged or broken. When myelin or the nerve fiber is destroyed or damaged, the nerve's ability to conduct electrical impulses to and from the brain is disrupted; therefore, nerve signals cannot be transmitted. The disruption of the electrical impulses causes the symptoms associated with MS. - this information is from GARD/ORDR/NCATS.

PDQ Definition: A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers. Check for active clinical trials using this agent. (NCI Thesaurus)

MEDLINEPLUS Definition: 

Multiple sclerosis (MS) is a nervous system disease that affects your brain and spinal cord. It damages the myelin sheath, the material that surrounds and protects your nerve cells. This damage slows down or blocks messages between your brain and your body, leading to the symptoms of MS. They can include

  • Visual disturbances
  • Muscle weakness
  • Trouble with coordination and balance
  • Sensations such as numbness, prickling, or "pins and needles"
  • Thinking and memory problems

No one knows what causes MS. It may be an autoimmune disease, which happens when your immune system attacks healthy cells in your body by mistake. Multiple sclerosis affects women more than men. It often begins between the ages of 20 and 40. Usually, the disease is mild, but some people lose the ability to write, speak, or walk.

There is no single test for MS. Doctors use a medical history, physical exam, neurological exam, MRI, and other tests to diagnose it. There is no cure for MS, but medicines may slow it down and help control symptoms. Physical and occupational therapy may also help.

NIH: National Institute of Neurological Disorders and Stroke

NICHD Definition: An autoimmune demyelinating disease characterized by a relapsing-remitting or progressive pattern of central nervous system impairment.

NCI-GLOSS Definition: A disorder of the central nervous system marked by weakness, numbness, a loss of muscle coordination, and problems with vision, speech, and bladder control. Multiple sclerosis is thought to be an autoimmune disease in which the body's immune system destroys myelin. Myelin is a substance that contains both protein and fat (lipid), serving as a nerve insulator and helping in the transmission of nerve signals.

CSP Definition: chronic disease characterized by presence of numerous areas of demyelination in the central nervous system with symptoms such as weakness, incoordination, paresthesis, and speech disturbances; the etiology is unknown.

MSH Definition: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)

Synonyms & Abbreviations: (see Synonym Details)
disseminated sclerosis
DS - Disseminated sclerosis
Generalised multiple sclerosis
Generalized multiple sclerosis (disorder)
Generalized multiple sclerosis
insular sclerosis
MS (Multiple Sclerosis)
MS - Multiple sclerosis
MS
Multiple sclerosis (disorder)
Multiple sclerosis - MS
Multiple Sclerosis [Disease/Finding]
Multiple sclerosis NOS
multiple sclerosis
SCLEROSIS MULTIPLE
SCLEROSIS, DISSEMINATED
SCLEROSIS, INSULAR
SCLEROSIS, MULTIPLE

External Source Codes: 
NCI Thesaurus Code C3243 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
ANSWER_CODE 1 LNC
ANSWER_CODE 28 LNC
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CITE Playbook RADLEX
Contributing_Source CTRP NCI
Contributing_Source MedDRA NCI
Contributing_Source NICHD NCI
CTV3ID F20.. SNOMEDCT_US
CTV3ID F202. SNOMEDCT_US
DATE_CREATED 01/15/1999 MEDLINEPLUS
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_FIRST_PUBLISHED 2010-12-21 PDQ
DATE_LAST_MODIFIED 2010-12-21 PDQ
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2042-2324 CSP
DISEASE_IDENTIFIER_ID 21587 GARD
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EXTERNALLY_DEFINED N LNC
FX D009188 MSH
HAS_GARD_PAGE true GARD
IAN DEFAULT ICD10
ICE Disseminated or multiple sclerosis: {NOS; brain stem; cord; generalized} ICD9CM
IDENTIFIER_TYPE_ID 1 GARD
INCLUSION_TERM Multiple sclerosis (of): brain stem ICD10
INCLUSION_TERM Multiple sclerosis (of): cord ICD10
INCLUSION_TERM Multiple sclerosis (of): disseminated ICD10
INCLUSION_TERM Multiple sclerosis (of): generalized ICD10
INCLUSION_TERM Multiple sclerosis (of): NOS ICD10
IPX G35 ICPC
IS_ACTIVE true GARD
IS_RARE false GARD
IS_SPANISH false GARD
MDA 19990101 MSH
MESH_DEFINITION An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903) NDFRT
MESH_DUI D009103 NDFRT
MESH_NAME Multiple Sclerosis NDFRT
MESH_UI M0014197 NDFRT
MMR 20100625 MSH
MN C10.114.375.500 MSH
MN C10.314.350.500 MSH
MN C20.111.258.250.500 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
MODULE_ID 731000124108 SNOMEDCT_US
MODULE_NAME US National Library of Medicine maintained module SNOMEDCT_US
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/multiplesclerosis.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/multiplesclerosis.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Institute of Neurological Disorders and Stroke http://www.ninds.nih.gov/ MEDLINEPLUS
NCI_THESAURUS_CODE C3243 PDQ
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Multiple Sclerosis NCI
NUI N0000002052 NDFRT
ORDER_NO 05895 ICD10CM
ORIG_STY Disease/diagnosis PDQ
PRIMARY_PATH 10028245$10052785$10012303$10029205$Multiple sclerosis$Multiple sclerosis acute and progressive$Demyelinating disorders$Nervous system disorders MDR
PRIMARY_SOC 10029205 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/10255/multiple-sclerosis/resources/1 GARD
RXAUI 3195433 RXNORM
RXAUI 3200118 RXNORM
RXAUI 3200119 RXNORM
RXAUI 3236921 RXNORM
RXCUI 1024685 RXNORM
SMQ_TERM_ADDVERSION 11.1 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 11.1 MDR
SMQ_TERM_SCOPE 1 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 192928003 NDFRT
SNOMED_CID 24700007 NDFRT
SNOMEDID DA-25010 SNOMEDCT_US
SNOMEDID DA-25018 SNOMEDCT_US
SOS Abnormal neural activity due to loss of myelin. AOD
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS G35 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~G35 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS G35 | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS G35 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~G35 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~F20.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~F202. SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~DA-25010 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~DA-25018 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T027212 MSH
TERMUI T027213 MSH
TERMUI T366472 MSH
TH NLM (1966) MSH
TH NLM (2000) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

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