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Plasma Cell Myeloma (CUI C0026764) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0026764

NCI Thesaurus Code: C3242  (see NCI Thesaurus info)

Semantic Type: Neoplastic Process

NCIt Definition: A bone marrow-based plasma cell neoplasm characterized by a serum monoclonal protein and skeletal destruction with osteolytic lesions, pathological fractures, bone pain, hypercalcemia, and anemia. Clinical variants include non-secretory myeloma, smoldering myeloma, indolent myeloma, and plasma cell leukemia. (WHO, 2001)

RADLEX Definition: A malignant tumor of plasma cells usually arising in the bone marrow; characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria, and anemia. [MeSH]

GARD Definition: Multiple myeloma is a cancer of the plasma cells in the bone marrow. Plasma cells help the body fight infection by producing proteins called antibodies. In multiple myeloma, plasma cells grow out of control in the bone marrow and form tumors in the areas of solid bone. The growth of these bone tumors makes it harder for the bone marrow to make healthy blood cells and platelets. This disease may also harm other tissues and organs, such as the kidneys. Multiple myeloma mainly affects older adults. Although the exact cause is unknown, there are several known risk factors that can increase a person's chance of getting this disease. - this information is from GARD/ORDR/NCATS.

PDQ Definition: A bone marrow-based plasma cell neoplasm characterized by a serum monoclonal protein and skeletal destruction with osteolytic lesions, pathological fractures, bone pain, hypercalcemia, and anemia. Clinical variants include non-secretory myeloma, smoldering myeloma, indolent myeloma, and plasma cell leukemia. (WHO, 2001) Check for active clinical trials using this agent. (NCI Thesaurus)

HPO Definition: A malignant plasma cell tumor growing within soft tissue or within the skeleton. [HPO:sdoelken]

MEDLINEPLUS Definition: 

Multiple myeloma is a cancer that begins in plasma cells, a type of white blood cell. These cells are part of your immune system, which helps protect the body from germs and other harmful substances. In time, myeloma cells collect in the bone marrow and in the solid parts of bones.

No one knows the exact causes of multiple myeloma, but it is more common in older people and African Americans. It can run in families. Common symptoms may include

  • Bone pain, often in the back or ribs
  • Broken bones
  • Weakness or fatigue
  • Weight loss
  • Frequent infections and fevers
  • Feeling very thirsty
  • Frequent urination

Doctors diagnose multiple myeloma using lab tests, imaging tests, and a bone marrow biopsy. Your treatment depends on how advanced the disease is and whether you have symptoms. If you have no symptoms, you may not need treatment right away. If you have symptoms, you may have chemotherapy, stem cell transplantation, radiation, or targeted therapy. Targeted therapy uses substances that attack cancer cells without harming normal cells.

NIH: National Cancer Institute

CDISC Definition: A malignant neoplasm of the bone marrow composed of plasma cells.

NCI-GLOSS Definition: A type of cancer that begins in plasma cells (white blood cells that produce antibodies).

CTEP Definition: CTEP_For_FDA: 90600228/Myeloma

CSP Definition: malignant neoplasm of plasma cells usually arising in the bone marrow and manifested by skeletal destruction, bone pain, and the presence of anomalous immunoglobulins.

MSH Definition: A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.

Synonyms & Abbreviations: (see Synonym Details)
Cell Myeloma, Plasma
Cell Myelomas, Plasma
Disease, Kahler
KAHLER DISEASE
Kahler's disease
KAHLER-BOZZOLO DISEASE
Kahlers disease
Multiple myeloma (clinical)
Multiple myeloma (disorder)
Multiple myeloma / Plasma cell neoplasm
Multiple Myeloma [Disease/Finding]
multiple myeloma and other plasma cell neoplasms
MULTIPLE MYELOMA MYELOMATOSIS
Multiple myeloma NOS
Multiple myeloma, no ICD-O subtype
Multiple myeloma, no International Classification of Diseases for Oncology subtype (morphologic abnormality)
Multiple myeloma, no International Classification of Diseases for Oncology subtype
Multiple Myeloma/Plasma Cell Myeloma
Multiple Myelomas
multiple myeloma
Multiples Myelom
Myeloma - multiple
Myeloma Multiple
MYELOMA, MULTIPLE
Myeloma, NOS
MYELOMA, PLASMA CELL, MALIGNANT
Myeloma, Plasma Cell
Myeloma, Plasma-Cell
Myeloma-Multiples
Myeloma-Multiple
Myelomas, Multiple
Myelomas, Plasma Cell
Myelomas, Plasma-Cell
Myelomatoses
MYELOMATOSIS MULTIPLE
myelomatosis
Myeloma
neoplasm, plasma cell
Peripheral plasma cell myeloma
Plasma cell myelomas
plasma cell myeloma
Plasma cell neoplasm / Multiple myeloma
plasma cell neoplasms
plasma cell neoplasm
Plasma-Cell Myelomas
Plasma-cell Myeloma
Plasmacytic myeloma

External Source Codes: 
NCI Thesaurus Code C3242 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN myeloma unspecified is probably MULTIPLE MYELOMA; solitary myeloma = PLASMACYTOMA MSH
AQL BL BS CF CH CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SC SE SU TH UL UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CODE_REF (C42.1) ICDO
Contributing_Source CDISC NCI
Contributing_Source CTEP NCI
Contributing_Source CTRP NCI
CTV3ID B630. SNOMEDCT_US
CTV3ID BBn0. SNOMEDCT_US
DATE_CREATED 06/28/1999 MEDLINEPLUS
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_CREATED 2015-01-22T00:04:00 GARD
DATE_LAST_MODIFIED 2006-03-28 PDQ
DATE_LAST_MODIFIED 2012-03-27 PDQ
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2004-0850 CSP
DISEASE_IDENTIFIER_ID 32281 GARD
DISEASE_IDENTIFIER_ID 4874 GARD
DISEASE_IDENTIFIER_ID 4875 GARD
DISEASE_IDENTIFIER_ID 4876 GARD
DISEASE_IDENTIFIER_ID 4878 GARD
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20050131 SNOMEDCT_US
EXCLUDES1 solitary myeloma (C90.3-) ICD10CM
EXCLUDES1 solitary plasmactyoma (C90.3-) ICD10CM
FX D009194 MSH
GENELOCUS ,1,3,q,2,2,-,q,3,4, OMIM
GENESYMBOL LIG4S OMIM
GENESYMBOL LIG4 OMIM
HAS_GARD_PAGE true GARD
IAN DEFAULT ICD10
ICD-O-3_Code 9732/3 NCI
ICD-O-3_CODE 9732/3 SNOMEDCT_US
ICE Kahler's disease; Myelomatosis ICD9CM
IDENTIFIER_SOURCE Orp GARD
IDENTIFIER_TYPE_ID 1 GARD
INCLUSION_TERM Kahler's disease ICD10
INCLUSION_TERM Medullary plasmacytoma ICD10
INCLUSION_TERM Myelomatosis ICD10
INCLUSION_TERM Plasma cell myeloma ICD10
IS_ACTIVE true GARD
IS_RARE true GARD
IS_SPANISH false GARD
LAST_REVIEW_DATE 2009-01-19T00:00:00 GARD
MDA 19990101 MSH
MESH_DEFINITION A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY. NDFRT
MESH_DUI D009101 NDFRT
MESH_NAME Multiple Myeloma NDFRT
MESH_UI M0014195 NDFRT
MIMTYPE 3 OMIM
MIMTYPEMEANING Phenotype description, molecular basis known. OMIM
MIMTYPEVALUE pound OMIM
MMR 20120703 MSH
MN C04.557.595.500 MSH
MN C14.907.454.460 MSH
MN C15.378.147.780.650 MSH
MN C15.378.463.515.460 MSH
MN C20.683.515.845 MSH
MN C20.683.780.650 MSH
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/multiplemyeloma.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/multiplemyeloma.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Cancer Institute http://www.nci.nih.gov/ MEDLINEPLUS
NCI_THESAURUS_CODE C3242 PDQ
NDFRT_KIND DISEASE_KIND NDFRT
Neoplastic_Status Malignant NCI
NUI N0000002050 NDFRT
ORDER_NO 02568 ICD10CM
ORIG_STY Cancer stage PDQ
ORIG_STY Neoplasm diagnosis PDQ
PID 10392 PDQ
PID 281 PDQ
PID 7017 PDQ
PRIMARY_PATH 10035226$10074470$10035227$10029104$Plasma cell myeloma$Plasma cell myelomas$Plasma cell neoplasms$Neoplasms benign, malignant and unspecified (incl cysts and polyps) MDR
PRIMARY_SOC 10029104 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/7108/multiple-myeloma/resources/1 GARD
REF http://orcid.org/0000-0001-6908-9849 HPO
RXAUI 3200096 RXNORM
RXAUI 3200097 RXNORM
RXAUI 3200711 RXNORM
RXAUI 3288402 RXNORM
RXAUI 3605992 RXNORM
RXAUI 3606121 RXNORM
RXAUI 3606122 RXNORM
RXAUI 5039663 RXNORM
RXCUI 1022141 RXNORM
SMQ_TERM_ADDVERSION 10.0 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 20.0 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 109989006 NDFRT
SOS Excludes: solitary myeloma (238.6) ICD9CM
SUBSET_MEMBER 446608001~MAPTARGET~9732/3 SNOMEDCT_US
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS C90.0 | POSSIBLE REQUIREMENT FOR MORPHOLOGY CODE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~C90.0 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS C90.00 | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~C90.00 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~B630. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~BBn0. SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERM_LEVEL 4 ICDO
TERM_LEVEL Synonym ICDO
TERMUI T027205 MSH
TERMUI T027206 MSH
TERMUI T727383 MSH
TERMUI T753627 MSH
TERMUI T767845 MSH
TERMUI T767846 MSH
TERMUI T811766 MSH
TH NLM (1966) MSH
TH NLM (2010) MSH
TH NLM (2011) MSH
TH OMIM (2013) MSH
TH ORD (2010) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

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