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Mucocutaneous Lymph Node Syndrome (CUI C0026691) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0026691

NCI Thesaurus Code: C34825  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: A vasculitis characterized by inflammation of the arteries, particularly the coronary arteries. The vasculitis may lead to aneurysm formation and possibly, heart attacks. It affects young children who usually present with persistent high fever, redness of the mucous membranes of the mouth, redness of the palms and soles, skin rashes, lymphadenitis, and joint pain and swelling.

RADLEX Definition: An acute, febrile, mucocutaneous condition accompanied by swelling of cervical lymph nodes in infants and young children. The principal symptoms are fever, congestion of the ocular conjunctivae, reddening of the lips and oral cavity, protuberance of tongue papillae, and edema or erythema of the extremities. [MeSH]

GARD Definition: Kawasaki syndrome is a condition that involves inflammation of the blood vessels.  It is typically diagnosed in young children, but older children and adults can also develop this condition.   Kawasaki syndrome is usually accompanied by a fever that lasts at least 5 days. Other classic symptoms may include red eyes, lips, and mouth; rash; swollen and red hands and feet; and swollen lymph nodes. Kawasaki syndrome occurs most often in people of Asian and Pacific Island descent.
- this information is from GARD/ORDR/NCATS.

MEDLINEPLUS Definition: 

Kawasaki disease is a rare childhood disease. It makes the walls of the blood vessels in the body become inflamed. It can affect any type of blood vessel, including the arteries, veins, and capillaries.

No one knows what causes Kawasaki disease. Symptoms include

  • High fever that lasts longer than 5 days
  • Swollen lymph nodes in the neck
  • A rash on the mid-section and genital area
  • Red, dry, cracked lips and a red, swollen tongue
  • Red, swollen palms of the hands and soles of the feet
  • Redness of the eyes

Kawasaki disease can't be passed from one child to another. There is no single test. To diagnose it, doctors look at the signs and symptoms. They may also use an echocardiogram or other tests. It is mainly treated with medicines. Rarely, medical procedures and surgery also may be used for children whose coronary arteries are affected.

Kawasaki disease can't be prevented. However, most children who develop the disease fully recover - usually within weeks of getting signs and symptoms. Further problems are rare.

NIH: National Heart, Lung, and Blood Institute

NICHD Definition: Medium-sized vessel vasculitis seen primarily in young children with predilection for the coronary arteries. Diagnosis is based on clinical findings of persistent high fever, changes in lips and oral mucous membranes, erythema and edema of hands/feet and later desquamation, bilateral bulbar conjunctivitis, unilateral cervical adenopathy, polymorphous rash.

CSP Definition: systemic disease primarily of infants and young children, characterized by skin rash, swelling of hands and feet, enlarged cervical lymph nodes, "strawberry tongue", dry and cracked lips, high fevers, and coronary artery disease.

MSH Definition: An acute, febrile, mucocutaneous condition accompanied by swelling of cervical lymph nodes in infants and young children. The principal symptoms are fever, congestion of the ocular conjunctivae, reddening of the lips and oral cavity, protuberance of tongue papillae, and edema or erythema of the extremities.

Synonyms & Abbreviations: (see Synonym Details)
Acute febrile MCLS
Acute febrile mucocutaneous lymph node syndrome (disorder)
Acute febrile mucocutaneous lymph node syndrome (MCLS)
Acute febrile mucocutaneous lymph node syndrome [MCLS]
Acute febrile mucocutaneous lymph node syndrome
Infantile Polyarteritis Nodosa
Kawasaki disease
KAWASAKI DIS
Kawasaki syndrome
Kawasaki Syndrom
Kawasaki's disease
Kawasaki's syndrome
Kawasakis mucocutaneous lymph node syndrome
KD
Lymph Node Syndrome, Mucocutaneous
MCLS
MLNS
Mucocutan lymph node syn
Mucocutaneous Lymph Node Syndrome [Disease/Finding]
Mucocutaneous lymph node syndrome [Kawasaki]
mucocutaneous lymph node syndrome

External Source Codes: 
NCI Thesaurus Code C34825 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN DF: MLNS or MCLS MSH
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Contributing_Source MedDRA NCI
Contributing_Source NICHD NCI
CTV3ID G7510 SNOMEDCT_US
DATE_CREATED 02/11/2009 MEDLINEPLUS
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0571-6720 CSP
DISEASE_IDENTIFIER_ID 4202 GARD
DISEASE_IDENTIFIER_ID 4203 GARD
DX 19840101 MSH
EFFECTIVE_TIME 20020731 SNOMEDCT_US
GENELOCUS ,1,9,q,1,3,.,2, OMIM
GENESYMBOL ITPKC OMIM
HAS_GARD_PAGE true GARD
HN 1984(77); use LYMPHATIC DISEASES 1977-1983 MSH
IAN DEFAULT ICD10
ICE Kawasaki disease ICD9CM
IDENTIFIER_TYPE_ID 1 GARD
IS_ACTIVE true GARD
IS_RARE true GARD
IS_SPANISH false GARD
LAST_REVIEW_DATE 2010-01-21T00:00:00 GARD
MDA 19760519 MSH
MESH_DEFINITION An acute, febrile, mucocutaneous condition accompanied by swelling of cervical lymph nodes in infants and young children. The principal symptoms are fever, congestion of the ocular conjunctivae, reddening of the lips and oral cavity, protuberance of tongue papillae, and edema or erythema of the extremities. NDFRT
MESH_DUI D009080 NDFRT
MESH_NAME Mucocutaneous Lymph Node Syndrome NDFRT
MESH_UI M0014162 NDFRT
MIMTYPE 3 OMIM
MIMTYPEMEANING Phenotype description, molecular basis known. OMIM
MIMTYPEVALUE pound OMIM
MMR 20130708 MSH
MN C14.907.940.560 MSH
MN C15.604.560 MSH
MN C17.800.862.560 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
MOVED_FROM 300530 OMIM
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/kawasakidisease.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/kawasakidisease.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Heart, Lung, and Blood Institute http://www.nhlbi.nih.gov/ MEDLINEPLUS
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Kawasaki Disease NCI
NUI N0000002042 NDFRT
ORDER_NO 17929 ICD10CM
PM 1984; see LYMPHATIC DISEASES 1977-1983 MSH
PRIMARY_PATH 10023320$10003231$10047116$10047065$Kawasaki's disease$Arterial inflammations$Vascular inflammations$Vascular disorders MDR
PRIMARY_SOC 10047065 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/6816/kawasaki-syndrome/resources/1 GARD
RXAUI 3184318 RXNORM
RXAUI 3190464 RXNORM
RXAUI 3199885 RXNORM
RXAUI 3199886 RXNORM
RXAUI 3287667 RXNORM
RXCUI 1023193 RXNORM
SMQ_TERM_ADDVERSION 12.0 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 12.0 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 75053002 NDFRT
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS M30.3 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~M30.3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS M30.3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~M30.3 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~G7510 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T027133 MSH
TERMUI T027134 MSH
TERMUI T027135 MSH
TERMUI T751046 MSH
TH GHR (2014) MSH
TH NLM (1977) MSH
TH NLM (2010) MSH
TH OMIM (2013) MSH
TH ORD (2010) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0026691

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