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Morphine (CUI C0026549) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0026549

NCI Thesaurus Code: C62051  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Pharmacologic Substance

NCIt Definition: An opiate alkaloid isolated from the plant Papaver somniferum and produced synthetically. Morphine binds to and activates specific opiate receptors (delta, mu and kappa), each of which are involved in controlling different brain functions. In the central nervous and gastrointestinal systems, this agent exhibits widespread effects including analgesia, anxiolysis, euphoria, sedation, respiratory depression, and gastrointestinal system smooth muscle contraction. (NCI04)

CSP Definition: principal and most active narcotic alkaloid of opium, having powerful analgesic action and some central stimulant action; abuse leads to dependence.

MSH Definition: The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.

Synonyms & Abbreviations: (see Synonym Details)
(-)-morphine
(5alpha,6alpha)-17-Methyl-7,8-didehydro-4,5-epoxymorphinan-3,6-diol
(5alpha,6alpha)-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol
(5R,6S,9R,13S,14R)-4,5-Epoxy-N-methyl-7-morphinen-3,6-diol
(7R,7AS,12bs)-3-methyl-2,3,4,4a,7,7a-hexahydro-1H-4,12-methano[1]benzofuro[3,2-e]isoquinoline-7,9-diol
Morfina
Morphia
Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-
Morphine (substance)
Morphine [Chemical/Ingredient]
morphine
Morphinum
Morphin
Morphium
MORPH
Product containing morphine (medicinal product)
Product containing morphine

External Source Codes: 
NCI Thesaurus Code C62051 (see NCI Thesaurus info)
CAS Registry Number 57-27-2 (see NLM ChemIDplus info)
FDA UNII Code 76I7G6D29C
NSC Code 11411 (see NCI DTP info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN /analogs = MORPHINE DERIVATIVES MSH
AQL AD AE AG AI AN BI BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:17303 NCI
Chemical_Formula C17H19NO3 NCI
CITE Playbook RADLEX
Contributing_Source FDA NCI
CTV3ID x02LY SNOMEDCT_US
CTV3ID XUWJz SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0092-7466 CSP
DX 19600101 MSH
EC analogs & derivatives:Morphine Derivatives MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20020731 SNOMEDCT_US
FDA_UNII_CODE 76I7G6D29C DRUGBANK
FDA_UNII_CODE 76I7G6D29C NDFRT
FX D011957 MSH
HN MORPHINE SULFATE was (NM) 1980-96 MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
MDA 19990101 MSH
MESH_DEFINITION The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle. NDFRT
MESH_DUI D009020 NDFRT
MESH_NAME Morphine NDFRT
MESH_UI M0014064 NDFRT
MMR 20160531 MSH
MN D03.132.577.249.562.571 MSH
MN D03.605.497.607.587 MSH
MN D03.633.400.686.607.587 MSH
MN D04.615.723.795.576.571 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000007070 NDFRT
NUI N0000145914 NDFRT
PA D000701 MSH
PA D009294 MSH
PM MORPHINE SULFATE was indexed under MORPHINE 1980-96 MSH
RN 76I7G6D29C MSH
RR 57-27-2 (Morphine) MSH
RR 6211-15-0 (sulfate (2:1) (salt) pentahydrate) MSH
RR 64-31-3 (sulfate (2:1) (salt) anhydrous) MSH
RR X3P646A2J0 MSH
RXAUI 2072405 RXNORM
RXAUI 227603 RXNORM
RXAUI 3195106 RXNORM
RXAUI 3195107 RXNORM
RXAUI 3199640 RXNORM
RXAUI 3199647 RXNORM
RXAUI 3199662 RXNORM
RXAUI 3199673 RXNORM
RXAUI 3279383 RXNORM
RXAUI 3622137 RXNORM
RXAUI 6396354 RXNORM
RXCUI 7052 RXNORM
SID APRD00215 DRUGBANK
SOS Slang names are listed in appendix B. Classification: narcotic analgesic agonists. See also Brompton cocktail. (RIS 27:217--14 entries) AOD
SOS The principal active ingredient in opium. (Raw opium is composed of approximately 10 percent morphine by weight.) Isolated in 1803 and named after Morpheus, the Greek god of dreams, morphine first received widespread use in the United States during the Civil War. Still one of the most useful of medical drugs, it is considered by some to be superior to all other pain relievers. In addition to pain relief, it reduces drive states and encourages sleep. Since the Harrison Narcotics Act and the spread of heroin use, the recreational use of morphine has declined, although the subjective effects of the two drugs in equivalent potencies are almost identical. AOD
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SUBSET_MEMBER 900000000000497000~MAPTARGET~x02LY SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUWJz SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T026955 MSH
TERMUI T026956 MSH
TH BAN (19XX) MSH
TH FDA SRS (2014) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^122^Active/Master NDFRT
VANDF_RECORD 50.6^37^Active/Master NDFRT
VUID 4017530 NDFRT

Additional Concept Data:  (none)

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