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Mitral Valve Prolapse Syndrome (CUI C0026267) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0026267

NCI Thesaurus Code: C50655  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: A fairly common and often benign valvular heart disorder characterized by redundancy or hooding of mitral valve leaflets so that they prolapse into the left atrium, often causing mitral regurgitation. It is often a symptomless condition but may be marked by varied symptoms (e.g. chest pain, fatigue, dizziness, dyspnea, or palpitations) leading in some cases to endocarditis or ventricular tachycardia.

RADLEX Definition: Abnormal protrusion of one or both of the leaflets of the mitral valve into the left atrium during systole. This may be accompanied by mitral regurgitation, systolic murmur, nonejection click, or cardiac arrhythmia. [MeSH]

HPO Definition: One or both of the leaflets (cusps) of the mitral valve bulges back into the left atrium upon contraction of the left ventricle. [HPO:probinson]

MEDLINEPLUS Definition: 

Mitral valve prolapse (MVP) occurs when one of your heart's valves doesn't work properly. The flaps of the valve are "floppy" and don't close tightly. Most people who have the condition are born with it. It also tends to run in families.

Most of the time, MVP doesn't cause any problems. Rarely, blood can leak the wrong way through the floppy valve. This can cause

  • Palpitations (feelings that your heart is skipping a beat, fluttering, or beating too hard or too fast)
  • Shortness of breath
  • Cough
  • Fatigue, dizziness, or anxiety
  • Migraine headaches
  • Chest discomfort

Most people who have mitral valve prolapse (MVP) don't need treatment because they don't have symptoms and complications. If you need treatment for MVP, medicines can help relieve symptoms or prevent complications. Very few people will need surgery to repair or replace the mitral valve.

MVP puts you at risk for infective endocarditis, a kind of heart infection. To prevent it, doctors used to prescribe antibiotics before dental work or certain surgeries. Now, only people at high risk of endocarditis need the antibiotics.

NIH: National Heart, Lung, and Blood Institute

FDA Definition: Prolapse of the mitral valve, often with regurgitation, associated with myxomatous proliferation of the leaflets of the mitral valve.

MSH Definition: Abnormal protrusion or billowing of one or both of the leaflets of MITRAL VALVE into the LEFT ATRIUM during SYSTOLE. This allows the backflow of blood into left atrium leading to MITRAL VALVE INSUFFICIENCY; SYSTOLIC MURMURS; or CARDIAC ARRHYTHMIA.

Synonyms & Abbreviations: (see Synonym Details)
Asynchronous valve closure syndrome
Ballon Mitralklappe
Ballonklappe
balloon mitral valve
balloon valve
BARLOW SYNDROME
Barlow Syndrom
BARLOW'S SYNDROME
BARLOWS SYNDROME
Click Murmur Syndrome
Click syndrome
Click-Murmur Syndrome, Mitral
Click-Murmur Syndrome, Systolic
Click-Murmur Syndromes
Click-Murmur Syndrome
Click/Murmur Syndrom
Familial mitral valve prolapse
Floppy Mitral Valves
Floppy mitral valve
Floppy valve syndrome
floppy valve
Floppy-Valve-Syndrom
HEART, SOLDIER
J.B. Barlow syndrome
J.B. Barlow's syndrome (disorder)
J.B. Barlow's syndrome
Klappenprolaps
Mitral (valve) prolapse
Mitral Click Murmur Syndrome
MITRAL CLICK-MURMUR SYNDROME
Mitral leaflet prolapse
MITRAL REGURGITATION, FAMILIAL
Mitral valve posterior leaflet prolapse
Mitral valve prolapse (disorder)
MITRAL VALVE PROLAPSE 1
Mitral Valve Prolapse [Disease/Finding]
MITRAL VALVE PROLAPSE SYNDROME
Mitral valve prolapse, familial, autosomal dominant
MITRAL VALVE PROLAPSE, FAMILIAL
Mitral valve prolapse, posterior leaflet
Mitral Valve Prolapses
MITRAL VALVE PROLAPSE
Mitral Valve, Floppy
Mitral Valve, Prolapsed
Mitral Valves, Floppy
Mitral Valves, Prolapsed
MVP - Mitral valve prolapse
MVP PROLAPSED MITRAL VALVE
MVP1
MVP
MYXOMATOUS VALVULAR DISEASE, FAMILIAL
PMV
Prolapse, Mitral Valve
Prolapsed Mitral Valves
Prolapsed mitral valve
Prolapses, Mitral Valve
Syndrome, Click-Murmur
Syndrome, Mitral Click-Murmur
Syndrome, Systolic Click-Murmur
Syndromes, Click-Murmur
Systolic Click Murmur Syndrome
Systolic Click-Murmur Syndrome
SYSTOLIC MURMUR-CLICK SYNDROME
Valve Prolapse, Mitral
Valve Prolapses, Mitral
Valve, Prolapse Of Mitral
Valve, Prolapsed Mitral
Valves, Prolapsed Mitral

External Source Codes: 
NCI Thesaurus Code C50655 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
COMMENT duplicate RADLEX
COMMENT Same as "mitral valve prolapse" RADLEX
Contributing_Source FDA NCI
CTV3ID X778A SNOMEDCT_US
CTV3ID XUbLj SNOMEDCT_US
DATE_CREATED 03/27/2002 MEDLINEPLUS
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_CREATED 2015-01-22T00:04:00 GARD
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 1390-4391 CSP
DID 1393-3757 CSP
DISEASE_IDENTIFIER_ID 12717 GARD
DISEASE_IDENTIFIER_ID 12718 GARD
DISEASE_IDENTIFIER_ID 12722 GARD
DISEASE_IDENTIFIER_ID 33743 GARD
DX 19790101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20040731 SNOMEDCT_US
FDA_Table Patient Code (Appendix B) NCI
GENELOCUS ,1,6,p,1,2,.,1,-,p,1,1,.,2, OMIM
GENESYMBOL MMVP1 OMIM
GENESYMBOL MVP OMIM
GENESYMBOL PMV OMIM
HAS_GARD_PAGE true GARD
HN 79 MSH
HPO_COMMENT Mitral valve prolapse can be associated with mitral regurgitation. HPO
IAN DEFAULT ICD10
IDENTIFIER_SOURCE Orp GARD
IDENTIFIER_TYPE_ID 1 GARD
INCLUSION_TERM Floppy mitral valve syndrome ICD10
IS_ACTIVE true GARD
IS_RARE true GARD
IS_SPANISH false GARD
MDA 19771206 MSH
MESH_DEFINITION Abnormal protrusion or billowing of one or both of the leaflets of MITRAL VALVE into the LEFT ATRIUM during SYSTOLE. This allows the backflow of blood into left atrium leading to MITRAL VALVE INSUFFICIENCY; SYSTOLIC MURMURS; or CARDIAC ARRHYTHMIA. NDFRT
MESH_DUI D008945 NDFRT
MESH_NAME Mitral Valve Prolapse NDFRT
MESH_UI M0013959 NDFRT
MIMTYPE 5 OMIM
MIMTYPEMEANING Mendelian phenotype or locus, molecular basis unknown. OMIM
MIMTYPEVALUE perc OMIM
MMR 20120703 MSH
MN C14.280.484.400.500 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/mitralvalveprolapse.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/mitralvalveprolapse.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Heart, Lung, and Blood Institute http://www.nhlbi.nih.gov/ MEDLINEPLUS
NDFRT_KIND DISEASE_KIND NDFRT
NUI N0000002020 NDFRT
PM 79 MSH
PRIMARY_PATH 10027730$10027723$10046973$10007541$Mitral valve prolapse$Mitral valvular disorders$Cardiac valve disorders$Cardiac disorders MDR
PRIMARY_SOC 10007541 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/3687/mitral-valve-prolapse-familial-autosomal-dominant/resources/1 GARD
REPLACED_BY RID3268 RADLEX
REPLACED_BY RID3269 RADLEX
RXAUI 3160926 RXNORM
RXAUI 3199180 RXNORM
RXAUI 3199190 RXNORM
RXAUI 3199191 RXNORM
RXAUI 3243250 RXNORM
RXAUI 3288035 RXNORM
RXAUI 5039088 RXNORM
RXAUI 5039861 RXNORM
RXCUI 1022189 RXNORM
SNOMED_CID 409712001 NDFRT
SNOMED_CID 8074002 NDFRT
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS I34.1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~I34.1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS I34.1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF HYPOGONADISM WITH MITRAL VALVE PROLAPSE AND INTELLECTUAL DISABILITY SYNDROME AND IF FEMALE CHOOSE E28.39 | MAP IS CONTEXT DEPENDENT FOR GENDER SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF HYPOGONADISM WITH MITRAL VALVE PROLAPSE AND INTELLECTUAL DISABILITY SYNDROME AND IF MALE CHOOSE E29.1 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | MAP IS CONTEXT DEPENDENT FOR GENDER SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF HYPOGONADISM WITH MITRAL VALVE PROLAPSE AND INTELLECTUAL DISABILITY SYNDROME CHOOSE F79 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF HYPOGONADISM WITH MITRAL VALVE PROLAPSE AND INTELLECTUAL DISABILITY SYNDROME CHOOSE I34.1 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~MAP SOURCE CONCEPT CANNOT BE CLASSIFIED WITH AVAILABLE DATA SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447638001 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447639009 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~4 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 721841001 | Hypogonadism with mitral valve prolapse and intellectual disability syndrome | AND IFA 248152002 | Female (finding) | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 721841001 | Hypogonadism with mitral valve prolapse and intellectual disability syndrome | AND IFA 248153007 | Male (finding) | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 721841001 | Hypogonadism with mitral valve prolapse and intellectual disability syndrome | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~OTHERWISE TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~E28.39 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~E29.1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~F79 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~I34.1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~ SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~X778A SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUbLj SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERM_STATUS Retired RADLEX
TERMUI T026747 MSH
TERMUI T026748 MSH
TERMUI T026749 MSH
TERMUI T026750 MSH
TERMUI T682348 MSH
TERMUI T811749 MSH
TERMUI T819041 MSH
TH NLM (1979) MSH
TH NLM (2008) MSH
TH OMIM (2013) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0026267

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