skip navigation links
National Cancer Institute
Enterprise Vocabulary Services
Box
NCIm Version: 201808 (Browser Version 2.9, using LexEVS 6.5.1)
SearchBox Top
SearchBox Bottom
Mitochondria (CUI C0026237) Suggest changes to this concept
Add to Cart

Terms & Properties

Concept Unique Identifier (CUI): C0026237

NCI Thesaurus Code: C13258  (see NCI Thesaurus info)

Semantic Type: Cell Component

NCIt Definition: Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Mitochondria contain distinctive ribosomes, transfer RNAs, amino acyl t-RNA synthetases, and elongation and termination factors. Mitochondria depend upon genes within the nucleus for many essential messenger RNAs. Mitochondria consist of two sets of membranes, a smooth continuous outer coat and an inner membrane arranged in tubules or more often in folds that form platelike double membranes (cristae). Mitochondria are the principal energy source of the cell and contains the cytochrome enzymes of terminal electron transport and the enzymes of the citric acid cycle, fatty acid oxidation, and oxidative phosphorylation. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP.

GO Definition: A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]

NCI-GLOSS Definition: Small structures in a cell that are found in the cytoplasm (fluid that surrounds the cell nucleus). Mitochondria make most of the energy for the cell and have their own genetic material that is different from the genetic material found in the nucleus. Many diseases are caused by mutations (changes) in the DNA of mitochondria. Mitochondria are cell organelles.

CSP Definition: self-replicating organelles found in cytoplasm bound by two membranes, the inner one folded into the interior as a series of projections; they are the principal sites of energy generation resulting from the oxidation of food, and contain the enzymes of the Krebs and fatty acid cycles and the respiratory pathway; they contain DNA and RNA for independent replication.

MSH Definition: Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)

UWDA Definition: Membranous cytoplasmic organelle the interior of which is subdivided by cristae.

FMA Definition: Membranous cytoplasmic organelle the interior of which is subdivided by cristae.

Synonyms & Abbreviations: (see Synonym Details)
Mitochondrial structure (cell structure)
Mitochondrial structure
Mitochondrial
mitochondria
Mitochondrion (cell structure)
mitochondrion

External Source Codes: 
NCI Thesaurus Code C13258 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN A 11 qualif except /cytol; /genet permitted; coord with organ /metab (IM) but not also organ /ultrastruct for metab studies, coord with organ /ultrastruct (IM) for morphol studies: TN 126; mitochondria of vasc or smooth musc tissue goes under MITOCHONDRIA, MUSCLE & do not coord with MUSCLE, SMOOTH or MUSCLE, SMOOTH, VASCULAR unless particularly discussed & then probably only NIM MSH
AQL CH CL DE EN GE IM ME MI PA PH PS RE SE TR UL VI MSH
AUTHORITY Bloom & Fawcett 1994:22, Nomina Anatomica 89:H10 FMA
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CTV3ID XaDnF SNOMEDCT_US
CTV3ID XaDnG SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0596-9251 CSP
DX 19600101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
GO_COMMENT Some anaerobic or microaerophilic organisms (e.g. Entamoeba histolytica, Giardia intestinalis and several Microsporidia species) do not have mitochondria, and contain mitochondrion-related organelles (MROs) instead, called mitosomes or hydrogenosomes, very likely derived from mitochondria. To annotate gene products located in these mitochondrial relics in species such as Entamoeba histolytica, Giardia intestinalis or others, please use GO:0032047 'mitosome' or GO:0042566 'hydrogenosome'. (See PMID:24316280 for a list of species currently known to contain mitochondrion-related organelles.) GO
GO_NAMESPACE cellular_component GO
GO_SUBSET goslim_aspergillus GO
GO_SUBSET goslim_candida GO
GO_SUBSET goslim_chembl GO
GO_SUBSET goslim_generic GO
GO_SUBSET goslim_metagenomics GO
GO_SUBSET goslim_pir GO
GO_SUBSET goslim_plant GO
GO_SUBSET goslim_yeast GO
GXR NIF_Subcellular:sao1860313010 GO
GXR Wikipedia:Mitochondrion GO
HN MITOCHONDRIAL CONTRACTION was heading 1969-96 (was see under MITOCHONDRIA 1975, was Prov 1969-74) MSH
MDA 19990101 MSH
MMR 20030709 MSH
MN A11.284.430.214.190.875.564 MSH
MN A11.284.835.626 MSH
PM MITOCHONDRIAL CONTRACTION was heading 1975-96 (see under MITOCHONDRIA 1975) MSH
SOS A cytoplasmic organelle of eukaryotic cells, enclosed by a double membrane. The inner membrane forms cristae and contains numerous small spheres attached by stalks on the inner surface. The components of the respiratory chain and the mechanism for ATP synthesis are part of the inner membrane. Major metabolic pathways involved in the oxidation of carbohydrates, lipids, and amino acids, and special biosynthetic pathways involving urea and heme synthesis are located in the mitochondrial matrix space. Mitochondria may have a role in the maintenance of cytoplasmic CA2+ levels. Mitochondria also contain a specific DNA containing genetic information for some of the mitochondrial proteins, and the biochemical equipment for limited protein synthesis. AOD
SUBSET_MEMBER 734138000~TARGETCOMPONENT~75056005 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XaDnF SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XaDnG SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
TERMUI T026686 MSH
TERMUI T026687 MSH
TH NLM (1966) MSH
TH NLM (1995) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
UWT Anatomical Structure UWDA

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0026237

Mainbox Bottom