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Metronidazole (CUI C0025872) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0025872

NCI Thesaurus Code: C651  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Pharmacologic Substance

NCIt Definition: A synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities. Although its mechanism of action is not fully elucidated, un-ionized metronidazole is readily taken up by obligate anaerobic organisms and is subsequently reduced by low-redox potential electron-transport proteins to an active, intermediate product. Reduced metronidazole causes DNA strand breaks, thereby inhibiting DNA synthesis and bacterial cell growth.

NCI-GLOSS Definition: A drug that is used to treat infection and is being studied in the treatment of cancer. It is a type of antibacterial, antiprotozoal, and anthelmintic.

CSP Definition: antiprotozoal and antibacterial effective against obligate anaerobes.

MSH Definition: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed).

Synonyms & Abbreviations: (see Synonym Details)
1-(2-hydroxy-1-ethyl)-2-methyl-5-nitroimidazole
1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole
1-(beta-Ethylol)-2-methyl-5-nitro-3-azapyrrole
1-(beta-Hydroxyethyl)-2-methyl-5-nitroimidazole
1-(beta-Oxyethyl)-2-methyl-5-nitroimidazole
1-(β-ethylol)-2-methyl-5-nitro-3-azapyrrole
1-(β-hydroxyethyl)-2-methyl-5-nitroimidazole
1-(β-oxyethyl)-2-methyl-5-nitroimidazole
1H-Imidazole-1-ethanol, 2-methyl-5-nitro-
2 Methyl 5 nitroimidazole 1 ethanol
2-methyl-1-(2-hydroxyethyl)-5-nitroimidazole
2-methyl-3-(2-hydroxyethyl)-4-nitroimidazole
2-methyl-5-nitroimidazole-1-ethanol
Flagyl I.V. RTU
Flagyl
Metro I.V.
Metronidazole (substance)
Metronidazole [Chemical/Ingredient]
metronidazole
Metronidazolum
Metronidazol
METRO
Product containing metronidazole (medicinal product)
Product containing metronidazole
Satric
Tricom

External Source Codes: 
NCI Thesaurus Code C651 (see NCI Thesaurus info)
CAS Registry Number 443-48-1 (see NLM ChemIDplus info)
FDA UNII Code 140QMO216E
NSC Code 50364 (see NCI DTP info)
NSC Code 69587 (see NCI DTP info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:6909 NCI
Chemical_Formula C6H9N3O3 NCI
Contributing_Source FDA NCI
CTV3ID ef1.. SNOMEDCT_US
CTV3ID XUVxl SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 1549-4919 CSP
DX 19650101 MSH
EFFECTIVE_TIME 20020731 SNOMEDCT_US
EFFECTIVE_TIME 20160131 SNOMEDCT_US
FDA_UNII_CODE 140QMO216E DRUGBANK
FDA_UNII_CODE 140QMO216E NDFRT
HN 64 MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
LT TRD PDQ
MDA 19990101 MSH
MESH_DEFINITION A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed). NDFRT
MESH_DUI D008795 NDFRT
MESH_NAME Metronidazole NDFRT
MESH_UI M0013695 NDFRT
MMR 20160531 MSH
MN D02.640.672.500 MSH
MN D03.383.129.308.658.500 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000005776 NDFRT
NUI N0000146194 NDFRT
PA D000890 MSH
PA D000981 MSH
PA D011838 MSH
RN 140QMO216E MSH
RR 443-48-1 (Metronidazole) MSH
RR 69198-10-3 (mono-HCl) MSH
RR 73334-05-1 (ester PO4) MSH
RR 76JC1633UF MSH
RR L500PR95QA MSH
RXAUI 2072355 RXNORM
RXAUI 224677 RXNORM
RXAUI 2597570 RXNORM
RXAUI 2599900 RXNORM
RXAUI 2756642 RXNORM
RXAUI 3091898 RXNORM
RXAUI 3092557 RXNORM
RXAUI 3194064 RXNORM
RXAUI 3194065 RXNORM
RXAUI 3198678 RXNORM
RXAUI 3198682 RXNORM
RXAUI 3727873 RXNORM
RXCUI 6922 RXNORM
SID APRD00631 DRUGBANK
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SUBSET_MEMBER 900000000000497000~MAPTARGET~XUVxl SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T026247 MSH
TERMUI T026248 MSH
TH BAN (19XX) MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH NLM (1998) MSH
TH USAN (1962) MSH
TH USP (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^431^Active/Master NDFRT
VANDF_RECORD 50.6^200^Active/Master NDFRT
VUID 4017836 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0025872

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