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Methemoglobinemia (CUI C0025637) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0025637

NCI Thesaurus Code: C34817  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: An inherited or acquired condition characterized by abnormally increased levels of methemoglobin in the blood.

HPO Definition: Abnormally increased levels of Methemoglobinemia in the blood. In this form of hemoglobin, there is an oxidized ferric iron (Fe +3) rather than the reduced ferrous form (Fe 2+) that is normally found in hemoglobin. Methemoglobin has a reduced affinity for oxygen, resulting in a reduced ability to release oxygen to tissues. [HPO:probinson]

NCI-GLOSS Definition: A condition in which a higher-than-normal amount of methemoglobin is found in the blood. Methemoglobin is a form of hemoglobin that cannot carry oxygen. In methemoglobinemia, tissues cannot get enough oxygen. Symptoms may include headache, dizziness, fatigue, shortness of breath, nausea, vomiting, rapid heartbeat, loss of muscle coordination, and blue-colored skin. Methemoglobinemia can be caused by injury or being exposed to certain drugs, chemicals, or foods. It can also be an inherited condition.

NICHD Definition: An inherited or acquired condition characterized by abnormally increased levels of methemoglobin in the blood.

MSH Definition: The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)

Synonyms & Abbreviations: (see Synonym Details)
Methaemoglobinaemia NOS
Methaemoglobinaemia, unspecified
METHAEMOGLOBINAEMIA
Methemoglobinemia (disorder)
Methemoglobinemia [Disease/Finding]
Methemoglobinemia NOS
Methemoglobinemia, unspecified
Methemoglobinemias
Methemoglobinemia

External Source Codes: 
NCI Thesaurus Code C34817 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN presence of methemoglobin in blood MSH
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Contributing_Source NICHD NCI
CTV3ID XUD5k SNOMEDCT_US
DATE_CREATED 2012-09-16T05:42:35Z HPO
DATE_FIRST_PUBLISHED 2009-08-12 PDQ
DATE_LAST_MODIFIED 2009-08-12 PDQ
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0449-0541 CSP
DID 1418-5137 CSP
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
IAN DEFAULT ICD10
ICA Use additional E code to identify cause ICD9CM
ICE Congenital NADH [DPNH]-methemoglobin-reductase deficiency; Hemoglobin M [Hb-M] disease; Methemoglobinemia: {NOS; acquired (with sulfhemoglobinemia); hereditary; toxic}; Stokvis' disease; Sulfhemoglobinemia ICD9CM
MDA 19990101 MSH
MESH_DEFINITION The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed) NDFRT
MESH_DUI D008708 NDFRT
MESH_NAME Methemoglobinemia NDFRT
MESH_UI M0013565 NDFRT
MMR 19940628 MSH
MN C15.378.619 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NCI_THESAURUS_CODE C34817 PDQ
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Methemoglobinemia NCI
NUI N0000002008 NDFRT
ORDER_NO 03526 ICD10CM
ORDER_NO 03529 ICD10CM
ORIG_STY Secondary related condition PDQ
PRIMARY_PATH 10027496$10018847$10018849$10005329$Methaemoglobinaemia$Haematological disorders$Haematological disorders NEC$Blood and lymphatic system disorders MDR
PRIMARY_SOC 10005329 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RXAUI 3198249 RXNORM
RXAUI 3198250 RXNORM
RXCUI 1023243 RXNORM
SNOMED_CID 38959009 NDFRT
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS D74.9 | MAPPED FOLLOWING WHO GUIDANCE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~D74.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS D74.9 | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~D74.9 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUD5k SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
TERMUI T025902 MSH
TH NLM (1966) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

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