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Methadone (CUI C0025605) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0025605

NCI Thesaurus Code: C62044  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Pharmacologic Substance

NCIt Definition: A synthetic opioid with analgesic activity. Methadone mimics the actions of endogenous peptides at CNS opioid receptors, primarily on the mu-receptor and has actions similar to those of morphine and morphine-like agents. The characteristic morphine-like effects include analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia and physical dependence. However, the detoxification symptoms between morphine-like agents and methadone differ in that the onset of methadone's withdrawal symptoms is slower, the course is more prolonged and the symptoms are less severe.

CSP Definition: synthetic narcotic possessing pharmacologic actions similar to those of morphine and heroin and almost equal addiction liability; used as an analgesic and as a narcotic abstinence syndrome suppressant in the treatment of heroin addition.

MSH Definition: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)

Synonyms & Abbreviations: (see Synonym Details)
(+-)-Methadone
(+/-)-Methadone
(±)-methadone
3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-
6-Dimethylamino-4,4-diphenyl-3-heptanone
dl-Methadone
Methadone (substance)
Methadone [Chemical/Ingredient]
methadone
Methadonum
Product containing methadone (medicinal product)
Product containing methadone

External Source Codes: 
NCI Thesaurus Code C62044 (see NCI Thesaurus info)
CAS Registry Number 76-99-3 (see NLM ChemIDplus info)
FDA UNII Code UC6VBE7V1Z

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN for methadone maintenance treatment, coordinate with OPIATE SUBSTITUTION TREATMENT MSH
AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:6807 NCI
Chemical_Formula C21H27NO NCI
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID x01KX SNOMEDCT_US
CTV3ID XUWtu SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2268-7060 CSP
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20030131 SNOMEDCT_US
FDA_UNII_CODE UC6VBE7V1Z DRUGBANK
FDA_UNII_CODE UC6VBE7V1Z NDFRT
FX D058850 MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
MDA 19990101 MSH
MESH_DEFINITION A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3) NDFRT
MESH_DUI D008691 NDFRT
MESH_NAME Methadone NDFRT
MESH_UI M0013541 NDFRT
MMR 20160701 MSH
MN D02.522.675 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006650 NDFRT
NUI N0000147909 NDFRT
PA D000701 MSH
PA D000996 MSH
PA D009294 MSH
RN UC6VBE7V1Z MSH
RR 1095-90-5 (HCl) MSH
RR 229809935B MSH
RR 76-99-3 (Methadone) MSH
RXAUI 2072262 RXNORM
RXAUI 221666 RXNORM
RXAUI 3093211 RXNORM
RXAUI 3192944 RXNORM
RXAUI 3192945 RXNORM
RXAUI 3198182 RXNORM
RXAUI 3198185 RXNORM
RXAUI 6395617 RXNORM
RXAUI 6395661 RXNORM
RXAUI 6396333 RXNORM
RXCUI 6813 RXNORM
SID APRD00485 DRUGBANK
SOS A synthetic opioid drug used in maintenance therapy for those dependent on opioids. It has a long half-life and can be given orally once daily with supervision. An opioid largely used in the maintenance treatment of heroin dependency because (1) it prevents heroin withdrawal symptoms; (2) it fulfills the addict's physical need for the drug; (3) at sufficiently high doses, it blocks the effects of heroin through cross-tolerance; thus, a shot of street heroin while undergoing methadone treatment will probably give no pleasurable effect; (4) it is a longer-acting drug than heroin, the average dose lasting 24 hours, thus making it more convenient to administer; (5) it is effective orally, thus breaking the reliance on the ritual of injection; and (6) it can be dispensed at a treatment center. The ultimate aim is to wean addicts from heroin and the heroin lifestyle and allow them to adjust to a new lifestyle through which they can then withdraw from methadone and live drug free. AOD
SOS Remainder of NIDA definition: It is thus often used not only for maintenance but for detoxification from opiate addiction by reducing doses gradually over a short period. Critics argue that because the patient is still dependent on an opiate narcotic, it is doubtful users will ever withdraw from methadone. Data have shown not only that people can become addicted to methadone in such legal settings but also that some people continue to use heroin and other illicit drugs while taking methadone and that for many people, methadone has become a drug of preference, thus generating an active illicit market. Some patients complain that methadone and the daily "treatment" process is just as disruptive as heroin use. Recently, a new synthetic opiate, LAAM, has been advocated as an alternative to methadone for treatment purposes because daily doses are not needed. AOD
SOS Slang name: dolly. Trade name: Dolophine. Classification: narcotic analgesic agonists. (RIS 27:214--125 entries) AOD
SPL_SET_ID 04d04496-36bb-46df-a6e9-5c8aa8578222 MTHSPL
SPL_SET_ID 052cc172-e3f8-436a-ad92-234c3b7b4e38 MTHSPL
SPL_SET_ID 092d78eb-6423-495c-bf0d-e6532bea7138 MTHSPL
SPL_SET_ID 0b72a120-ca4e-4b90-7d89-52967a39adb3 MTHSPL
SPL_SET_ID 1deb3865-48b5-4860-880f-625f912d7ed4 MTHSPL
SPL_SET_ID 20127592-3a20-e280-2c70-f3d4e1ce009f MTHSPL
SPL_SET_ID 2c560dba-8b7e-4ba1-a390-30fff6af8aeb MTHSPL
SPL_SET_ID 3c926b78-999e-4d26-9498-7f1bcaf0b992 MTHSPL
SPL_SET_ID 401e17da-0314-49bd-9c2c-8321be129f66 MTHSPL
SPL_SET_ID 44d6011b-c4b8-44b8-bff9-8655f0443901 MTHSPL
SPL_SET_ID 4a3b2bc3-d837-4ca9-aee1-452633b6a06b MTHSPL
SPL_SET_ID 4c796a39-d87f-4358-9d4b-26e27464b642 MTHSPL
SPL_SET_ID 544483e6-6f9d-4371-9e93-313e54e0ea05 MTHSPL
SPL_SET_ID 552751F7-42FF-40C7-8495-A6AA306D5C23 MTHSPL
SPL_SET_ID 5e23b861-c635-4749-9c2a-be9d4a501823 MTHSPL
SPL_SET_ID 5E70E915-B946-4A80-BCC6-3F49BC30F2F5 MTHSPL
SPL_SET_ID 6059a68d-5434-4a0e-9f53-b793c3dc8630 MTHSPL
SPL_SET_ID 6984eb5a-57a3-4686-bc67-91bc3e7a531e MTHSPL
SPL_SET_ID 7a4840d6-98e3-4523-81a0-ef0b3a47d0c2 MTHSPL
SPL_SET_ID 7d83edfd-b529-41b6-beea-e91316dd0c7b MTHSPL
SPL_SET_ID 7ff89589-149c-4007-8144-5f60131b8c33 MTHSPL
SPL_SET_ID 802ab399-479b-4271-a2a7-07aadde91cff MTHSPL
SPL_SET_ID 808a9d0b-720b-4034-a862-5122ff514608 MTHSPL
SPL_SET_ID 8c363f90-c378-48ae-abbc-aeb25c9bf5cb MTHSPL
SPL_SET_ID 9bbe219f-3bf1-44f4-a709-cd108c4fa9ef MTHSPL
SPL_SET_ID a36705c4-867f-41f1-94c9-78b8b31836ce MTHSPL
SPL_SET_ID aa8e14c1-fbfd-4e4d-b59e-2d4ae1ca815f MTHSPL
SPL_SET_ID af2fa7bc-5d43-47d8-835e-b9adc565600a MTHSPL
SPL_SET_ID b2373917-5c7d-4199-be4e-3cf79690a631 MTHSPL
SPL_SET_ID bba507c1-d23a-4a05-9539-3c6131076c65 MTHSPL
SPL_SET_ID c3c1b3f7-3bb1-4864-b634-8fc9dbaac9bb MTHSPL
SPL_SET_ID c54baaee-8ea4-45f5-a5c8-bb84cf86832f MTHSPL
SPL_SET_ID cf106b94-9c17-4a22-a1ba-ad45d32b41ce MTHSPL
SPL_SET_ID cf10ec82-1f41-45c0-b438-5ade38b5625a MTHSPL
SPL_SET_ID d0e6a966-179a-45e0-8444-4c1b8523f8d2 MTHSPL
SPL_SET_ID d3b7a707-78af-4fd5-9b66-b63050bbd6f6 MTHSPL
SPL_SET_ID d5bd3e97-b3f6-4bc2-9fb7-02921be35cdb MTHSPL
SPL_SET_ID DA0A54C6-8B53-4774-8C40-E615AC8D804D MTHSPL
SPL_SET_ID db37a292-5685-4f10-92fc-57631e1a25f9 MTHSPL
SPL_SET_ID e6af84de-cbfc-4a3b-bd73-6bcf77337168 MTHSPL
SPL_SET_ID e72841bf-364b-49b1-8e69-7e26ddcd2657 MTHSPL
SPL_SET_ID ec41ab86-a948-44e4-b21c-c65a22cdf294 MTHSPL
SPL_SET_ID eddf7077-02fb-4771-9823-31984f4ff2bb MTHSPL
SPL_SET_ID f2057290-4286-4581-9711-50a0a834e228 MTHSPL
SPL_SET_ID f7805bcf-023a-48df-a5c9-23a04d11d621 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~x01KX SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUWtu SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T025833 MSH
TH BAN (19XX) MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH NLM (1966) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^2443^Active/Master NDFRT
VANDF_RECORD 50.6^11^Active/Master NDFRT
VUID 4019820 NDFRT

Additional Concept Data:  (none)

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