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Melatonin (CUI C0025219) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0025219

NCI Thesaurus Code: C2267  (see NCI Thesaurus info)

Semantic Type: Pharmacologic Substance

Semantic Type: Organic Chemical

Semantic Type: Hormone

NCIt Definition: A hormone involved in sleep regulatory activity, and a tryptophan-derived neurotransmitter, which inhibits the synthesis and secretion of other neurotransmitters such as dopamine and GABA. Melatonin is synthesized from serotonin intermediate in the pineal gland and the retina where the enzyme 5-hydroxyindole-O-methyltransferase, that catalyzes the last step of synthesis, is found. This hormone binds to and activates melatonin receptors and is involved in regulating the sleep and wake cycles. In addition, melatonin possesses antioxidative and immunoregulatory properties via regulating other neurotransmitters.

NCI-GLOSS Definition: A hormone made by the pineal gland (tiny organ near the center of the brain). Melatonin helps control the body's sleep cycle, and is an antioxidant. It is also made in the laboratory and sold as a supplement.

CSP Definition: 5-methoxy-N-acetyltryptamine, a pineal hormone involved in modulation of skin pigmentation, gonad development, and circadian rhythms.

MSH Definition: A biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of SLEEP, mood, and REPRODUCTION. Melatonin is also an effective antioxidant.

Synonyms & Abbreviations: (see Synonym Details)
5-methoxy-N-acetyltryptamine
Acetamide, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)-
melanocyte-inhibiting factor
Melatonin (substance)
Melatonin [Chemical/Ingredient]
Melatonine
melatonin
MIH
N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide
N-[2-(5-methoxyindol-3-yl)ethyl]acetamide
N-Acetyl-5-methoxytryptamine

External Source Codes: 
NCI Thesaurus Code C2267 (see NCI Thesaurus info)
CAS Registry Number 73-31-4 (see NLM ChemIDplus info)
NSC Code 113928 (see NCI DTP info)
NSC Code 56423 (see NCI DTP info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BI BL CF CH CL CS CT DF EC GE HI IM IP ME PD PH PK PO RE SD SE ST TO TU UR MSH
AUTHORITY Bloom & Fawcett 94:516 FMA
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CHEBI_ID CHEBI:16796 NCI
Contributing_Source CTRP NCI
CTV3ID XUDZh SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2334-4121 CSP
DX 19680101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
FDA_UNII_CODE JL5DK93RCL DRUGBANK
FDA_UNII_CODE JL5DK93RCL NDFRT
HN 68(65) MSH
HN ETOH descriptor 1995. AOD
LEVEL Ingredient NDFRT
MDA 19990101 MSH
MESH_DEFINITION A biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of SLEEP, mood, and REPRODUCTION. Melatonin is also an effective antioxidant. NDFRT
MESH_DUI D008550 NDFRT
MESH_NAME Melatonin NDFRT
MESH_UI M0013319 NDFRT
MMR 20160531 MSH
MN D03.633.100.473.914.481 MSH
MN D06.472.506 MSH
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000010145 NDFRT
NUI N0000148757 NDFRT
PA D000975 MSH
PA D002492 MSH
PM 68 MSH
RN JL5DK93RCL MSH
RR 73-31-4 (Melatonin) MSH
RXAUI 3104697 RXNORM
RXAUI 3192125 RXNORM
RXAUI 3192126 RXNORM
RXAUI 3197274 RXNORM
RXAUI 3197292 RXNORM
RXAUI 3631969 RXNORM
RXAUI 4234588 RXNORM
RXCUI 6711 RXNORM
SID APRD00742 DRUGBANK
SID DB08189 DRUGBANK
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SPL_SET_ID fdaf86c2-137d-4926-a63b-9faf7ec7e04c MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUDZh SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
TERMUI T025444 MSH
TH FDA SRS (2014) MSH
TH NLM (1965) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
UWT Anatomical Structure UWDA
VANDF_RECORD 50.416^3997^Active/Master NDFRT
VANDF_RECORD 50.6^3790^Active/Master NDFRT
VUID 4021324 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0025219

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