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melanoma (CUI C0025202) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0025202

NCI Thesaurus Code: C3224  (see NCI Thesaurus info)

Semantic Type: Neoplastic Process

NCIt Definition: A malignant, usually aggressive tumor composed of atypical, neoplastic melanocytes. Most often, melanomas arise in the skin (cutaneous melanomas) and include the following histologic subtypes: superficial spreading melanoma, nodular melanoma, acral lentiginous melanoma, and lentigo maligna melanoma. Cutaneous melanomas may arise from acquired or congenital melanocytic or dysplastic nevi. Melanomas may also arise in other anatomic sites including the gastrointestinal system, eye, urinary tract, and reproductive system. Melanomas frequently metastasize to lymph nodes, liver, lungs, and brain.

HPO Definition: The presence of a melanoma, a malignant cancer originating from pigment producing melanocytes. Melanoma can originate from the skin or the pigmented layers of the eye (the uvea). [HPO:probinson]

MEDLINEPLUS Definition: 

Melanoma is the most serious type of skin cancer. Often the first sign of melanoma is a change in the size, shape, color, or feel of a mole. Most melanomas have a black or black-blue area. Melanoma may also appear as a new mole. It may be black, abnormal, or "ugly looking."

Thinking of "ABCDE" can help you remember what to watch for:

  • Asymmetry - the shape of one half does not match the other
  • Border - the edges are ragged, blurred or irregular
  • Color - the color is uneven and may include shades of black, brown and tan
  • Diameter - there is a change in size, usually an increase
  • Evolving - the mole has changed over the past few weeks or months

Surgery is the first treatment of all stages of melanoma. Other treatments include chemotherapy and radiation, biologic, and targeted therapies. Biologic therapy boosts your body's own ability to fight cancer. Targeted therapy uses substances that attack cancer cells without harming normal cells.

NIH: National Cancer Institute

CDISC Definition: A malignant neoplasm composed of melanocytes.

NCI-GLOSS Definition: A form of cancer that begins in melanocytes (cells that make the pigment melanin). It may begin in a mole (skin melanoma), but can also begin in other pigmented tissues, such as in the eye or in the intestines.

NICHD Definition: A malignant neoplasm comprised of melanocytes typically arising in the skin.

CTEP Definition: CTEP_For_FDA: 90600020/Malignant melanoma site/stage unspecified

CSP Definition: malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites; occurring mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo; frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved.

MSH Definition: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)

Synonyms & Abbreviations: (see Synonym Details)
Malignant melanoma (disorder)
Malignant melanoma, no ICD-O subtype
Malignant melanoma, no International Classification of Diseases for Oncology subtype (morphologic abnormality)
Malignant melanoma, no International Classification of Diseases for Oncology subtype
Malignant melanoma, NOS
Malignant Melanomas
Malignant Melanoma
Melanoma [Disease/Finding]
MELANOMA MALIGNANT
MELANOMA, MALIGNANT
Melanoma, NOS
Melanomas, Malignant
Melanomas
melanoma
Melanosarcoma
MM - Malignant melanoma
Skin cancer, melanoma

External Source Codes: 
NCI Thesaurus Code C3224 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN /blood supply /chem /second /secret /ultrastruct permitted; coord IM with precoord organ/neopl term (IM); MELANOMA, EXPERIMENTAL is also available MSH
ANSWER_CODE 5 LNC
ANSWER_CODE 6 LNC
ANSWER_CODE 9 LNC
AQL BL BS CF CH CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SC SE SU TH UL UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CITE Playbook RADLEX
Contributing_Source CDISC NCI
Contributing_Source CTEP NCI
Contributing_Source CTRP NCI
Contributing_Source MedDRA NCI
Contributing_Source NICHD NCI
CTV3ID Xa99S SNOMEDCT_US
CTV3ID XUVry SNOMEDCT_US
DATE_CREATED 06/03/1999 MEDLINEPLUS
DATE_LAST_MODIFIED 2009-10-19 PDQ
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2020-2434 CSP
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20020731 SNOMEDCT_US
EXTERNALLY_DEFINED N LNC
HPO_COMMENT A malignant skin tumor of originating from melanocytes, pigment cells normally present in the epidermis and sometimes in the dermis. HPO
ICD-O-3_Code 8720/3 NCI
ICD-O-3_CODE 8720/3 SNOMEDCT_US
MDA 19990101 MSH
MESH_DEFINITION A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445) NDFRT
MESH_DUI D008545 NDFRT
MESH_NAME Melanoma NDFRT
MESH_UI M0013309 NDFRT
MMR 19960610 MSH
MN C04.557.465.625.650.510 MSH
MN C04.557.580.625.650.510 MSH
MN C04.557.665.510 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/melanoma.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Chinese - Simplified https://www.nlm.nih.gov/medlineplus/languages/melanoma.html#Chinese - Simplified MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Chinese - Traditional https://www.nlm.nih.gov/medlineplus/languages/melanoma.html#Chinese - Traditional MEDLINEPLUS
MP_OTHER_LANGUAGE_URL French https://www.nlm.nih.gov/medlineplus/languages/melanoma.html#French MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Hindi https://www.nlm.nih.gov/medlineplus/languages/melanoma.html#Hindi MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Japanese https://www.nlm.nih.gov/medlineplus/languages/melanoma.html#Japanese MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Korean https://www.nlm.nih.gov/medlineplus/languages/melanoma.html#Korean MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Russian https://www.nlm.nih.gov/medlineplus/languages/melanoma.html#Russian MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Somali https://www.nlm.nih.gov/medlineplus/languages/melanoma.html#Somali MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/melanoma.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Cancer Institute http://www.nci.nih.gov/ MEDLINEPLUS
NDFRT_KIND DISEASE_KIND NDFRT
Neoplastic_Status Malignant NCI
NICHD_Hierarchy_Term Melanoma NCI
NUI N0000001969 NDFRT
ORIG_STY Neoplasm diagnosis PDQ
PID 1302 PDQ
PRIMARY_PATH 10025650$10027156$10040900$10029104$Malignant melanoma$Skin melanomas (excl ocular)$Skin neoplasms malignant and unspecified$Neoplasms benign, malignant and unspecified (incl cysts and polyps) MDR
PRIMARY_SOC 10029104 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RXAUI 3196387 RXNORM
RXAUI 3197236 RXNORM
RXAUI 3197239 RXNORM
RXCUI 1023577 RXNORM
SID HP:0002887 HPO
SID HP:0006777 HPO
SID HP:0007474 HPO
SMQ_TERM_ADDVERSION 10.0 MDR
SMQ_TERM_ADDVERSION 12.0 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 14.0 MDR
SMQ_TERM_LMVERSION 20.0 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 372244006 NDFRT
SNOMEDID DF-00642 SNOMEDCT_US
SNOMEDID M-87203 SNOMEDCT_US
SUBSET_MEMBER 446608001~MAPTARGET~8720/3 SNOMEDCT_US
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS C43.9 | POSSIBLE REQUIREMENT FOR MORPHOLOGY CODE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~C43.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS C43.9 | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~C43.9 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~Xa99S SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUVry SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~DF-00642 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~M-87203 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERM_LEVEL 4 ICDO
TERM_LEVEL Synonym ICDO
TERMUI T025423 MSH
TERMUI T025424 MSH
TH NLM (1966) MSH
TH NLM (1994) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0025202

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