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Malignant hyperpyrexia due to anesthesia (CUI C0024591) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0024591

NCI Thesaurus Code: C84869  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: A rare disorder characterized by rapid rise of the body temperature, accompanied by rhabdomyolysis and, if untreated, by collapse and death. It occurs in susceptible individuals who receive certain drugs for general anesthesia, gas anesthetics, or succinylcholine. It may be inherited in an autosomal dominant pattern.

GARD Definition: Malignant hyperthermia (MH) is a severe reaction to certain gases used during anesthesia and/or a muscle relaxant used to temporarily paralyze a person during surgery. Signs and symptoms of MH include marked hyperthermia, a rapid heart rate, rapid breathing, acidosis, muscle rigidity, and breakdown of muscle tissue (rhabdomyolysis). Without prompt treatment, MH can be life-threatening. People who are at increased risk for this reaction are said to have MH susceptibility. Susceptibility to MH may be caused by mutations in any of several genes and is inherited in an autosomal dominant manner. People with certain inherited muscle diseases (e.g., central core disease and multiminicore disease) also have MH susceptibility. - this information is from GARD/ORDR/NCATS.

HPO Definition: Malignant hyperthermia is characterized by a rapid increase in temperature to 39-42 degrees C in response to inhalational anesthetics such as halothane or to muscle relaxants such as succinylcholine. [HPO:curators]

NICHD Definition: A rare drug reaction characterized by a rapid rise of the body temperature and rhabdomyolysis.

CSP Definition: usually inherited reaction to general anesthesia manifested as a sudden, rapid rise in temperature, hypermetabolism, and skeletal muscle rigidity; mutation is in the calcium release channel of skeletal muscle sarcoplasmic reticulum.

MSH Definition: Rapid and excessive rise of temperature accompanied by muscular rigidity following general anesthesia.

Synonyms & Abbreviations: (see Synonym Details)
Anesthesia Hyperthermias
Anesthesia Hyperthermia
Anesthesia Related Hyperthermias
anesthesia related hyperthermia
FEVER MALIGNANT
HYPERPYREXIA MALIGNANT
HYPERPYREXIA, FULMINATING
Hyperpyrexia, malignant
Hyperpyrexias, Malignant
HYPERTHERMIA MALIGNANT
hyperthermia of anesthesia
Hyperthermia, Anesthesia Related
HYPERTHERMIA, MALIGNANT
Hyperthermias, Anesthesia Related
Malignant hyperpyrexia caused by anaesthesia
Malignant hyperpyrexia caused by anaesthetic
Malignant hyperpyrexia caused by anesthesia
Malignant hyperpyrexia caused by anesthetic (finding)
Malignant hyperpyrexia caused by anesthetic
Malignant hyperpyrexia due to anaesthesia
Malignant hyperpyrexia due to anaesthetic
Malignant hyperpyrexia due to anesthesia
Malignant hyperpyrexia due to anesthetic
Malignant Hyperpyrexias
Malignant Hyperpyrexia
MALIGNANT HYPERTHEMIA
Malignant hyperthermia (finding)
Malignant Hyperthermia [Disease/Finding]
Malignant hyperthermia caused by anaesthesia
Malignant hyperthermia caused by anesthesia
Malignant hyperthermia due to anaesthesia
Malignant hyperthermia due to anesthesia
Malignant Hyperthermia Syndrome
Malignant hyperthermia with anesthesia
MALIGNANT HYPERTHERMIA, SUSCEPTIBILITY TO, 1
Malignant Hyperthermias
Malignant Hyperthermia
MH - Malignant hyperpyrexia
MHS - Malignant hyperthermia
MHS1
MHS
MH
Related Hyperthermia, Anesthesia
Related Hyperthermias, Anesthesia

External Source Codes: 
NCI Thesaurus Code C84869 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL BL CF CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Contributing_Source MedDRA NCI
Contributing_Source NICHD NCI
CTV3ID SN5y0 SNOMEDCT_US
CTV3ID XUaKg SNOMEDCT_US
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_CREATED 2015-01-22T00:04:00 GARD
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2871-4352 CSP
DISEASE_IDENTIFIER_ID 11605 GARD
DISEASE_IDENTIFIER_ID 11607 GARD
DISEASE_IDENTIFIER_ID 11608 GARD
DISEASE_IDENTIFIER_ID 33078 GARD
DISEASE_IDENTIFIER_ID 33079 GARD
DISEASE_IDENTIFIER_ID 33080 GARD
DISEASE_IDENTIFIER_ID 4642 GARD
DISEASE_IDENTIFIER_ID 4643 GARD
DISEASE_IDENTIFIER_ID 4644 GARD
DISEASE_IDENTIFIER_ID 4647 GARD
DX 19730101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20040131 SNOMEDCT_US
FX D005334 MSH
GENELOCUS ,1,9,q,1,3,.,1, OMIM
GENESYMBOL CCO OMIM
GENESYMBOL MHS OMIM
GENESYMBOL RYR1 OMIM
HAS_GARD_PAGE true GARD
HN 73 MSH
IAN DEFAULT ICD10
ICE Malignant hyperpyrexia due to anesthesia ICD9CM
IDENTIFIER_SOURCE Orp GARD
IDENTIFIER_TYPE_ID 1 GARD
IS_ACTIVE true GARD
IS_RARE true GARD
IS_SPANISH false GARD
LAST_REVIEW_ACTION Modified GARD
MDA 19990101 MSH
MESH_DEFINITION Rapid and excessive rise of temperature accompanied by muscular rigidity following general anesthesia. NDFRT
MESH_DUI D008305 NDFRT
MESH_NAME Malignant Hyperthermia NDFRT
MESH_UI M0012932 NDFRT
MIMTYPE 3 OMIM
MIMTYPEMEANING Phenotype description, molecular basis known. OMIM
MIMTYPEVALUE pound OMIM
MMR 20130708 MSH
MN C23.550.505.700 MSH
MN C23.550.767.600 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
MOVED_FROM 102990 OMIM
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Malignant Hyperthermia NCI
NUI N0000001928 NDFRT
ORDER_NO 82577 ICD10CM
PM 73 MSH
PRIMARY_PATH 10020844$10005907$10005908$10018065$Hyperthermia malignant$Body temperature altered$Body temperature conditions$General disorders and administration site conditions MDR
PRIMARY_SOC 10018065 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/6964/malignant-hyperthermia/resources/1 GARD
RXAUI 3174467 RXNORM
RXAUI 3174613 RXNORM
RXAUI 3196367 RXNORM
RXAUI 3196370 RXNORM
RXAUI 3196371 RXNORM
RXAUI 5039483 RXNORM
RXAUI 5930204 RXNORM
RXCUI 1021939 RXNORM
SID HP:0004896 HPO
SMQ_TERM_ADDVERSION 9.0 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 9.0 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 213026003 NDFRT
SNOMED_CID 405501007 NDFRT
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS T88.3 | POSSIBLE REQUIREMENT FOR AN EXTERNAL CAUSE CODE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~T88.3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS T41.45X? | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | EPISODE OF CARE INFORMATION NEEDED | POSSIBLE REQUIREMENT FOR AN EXTERNAL CAUSE CODE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS T88.3XX? | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | EPISODE OF CARE INFORMATION NEEDED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF MALIGNANT HYPERTHERMIA WITH ARTHROGRYPOSIS AND TORTICOLLIS SYNDROME CHOOSE Q68.0 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF MALIGNANT HYPERTHERMIA WITH ARTHROGRYPOSIS AND TORTICOLLIS SYNDROME CHOOSE Q68.8 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF MALIGNANT HYPERTHERMIA WITH ARTHROGRYPOSIS AND TORTICOLLIS SYNDROME CHOOSE R50.9 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~MAP SOURCE CONCEPT CANNOT BE CLASSIFIED WITH AVAILABLE DATA SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447638001 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447639009 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 719398004 | Malignant hyperthermia with arthrogryposis and torticollis syndrome | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~OTHERWISE TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~Q68.0 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~Q68.8 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~R50.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~T41.45X? SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~T88.3XX? SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~ SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~SN5y0 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUaKg SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T024766 MSH
TERMUI T024767 MSH
TERMUI T024768 MSH
TERMUI T024769 MSH
TERMUI T817898 MSH
TERMUI T841949 MSH
TH GHR (2014) MSH
TH NLM (1973) MSH
TH NLM (2014) MSH
TH OMIM (2013) MSH
TH ORD (2010) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
USE_ADDITIONAL code for adverse effect, if applicable, to identify drug (T41.- with fifth or sixth character 5) ICD10CM

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0024591

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