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Lupus Erythematosus, Systemic (CUI C0024141) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0024141

NCI Thesaurus Code: C3201  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: An autoimmune multi-organ disease typically associated with vasculopathy and autoantibody production. Most patients have antinuclear antibodies (ANA). The presence of anti-dsDNA or anti-Smith antibodies are highly-specific.

HPO Definition: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. [HPO:probinson]

NCI-GLOSS Definition: A chronic, inflammatory, connective tissue disease that can affect many organs including the joints, skin, heart, lungs, kidneys, and nervous system. It is marked by many different symptoms; however, not everyone with SLE has all of the symptoms.

NICHD Definition: An autoimmune multi-organ disease typically associated with vasculopathy and autoantibody production. Most patients have antinuclear antibodies (ANA). The presence of anti-dsDNA or anti-Smith antibodies are highly-specific.

CSP Definition: chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes; it is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system; the disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.

MSH Definition: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.

Synonyms & Abbreviations: (see Synonym Details)
disseminated lupus erythematosus
LE SYNDROME
LE systemic
LUPUS ERYTHEMATOSIS (NOS)
LUPUS ERYTHEMATOSIS DISSEMINATED
Lupus Erythematosus Disseminatus
LUPUS ERYTHEMATOSUS SYSTEMIC
LUPUS ERYTHEMATOSUS, DISSEMINATED
Lupus Erythematosus, Systemic [Disease/Finding]
LUPUS ERYTHEMATOSUS, SYSTEMIC
LUPUS SYNDROME
LUPUS, ERYTHEMATOSUS, SYSTEMIC
lupus
SLE - Lupus Erythematosus, Systemic
SLE - Systemic lupus erythematosus
SLE NOS
SLE
SYNDROME DISSEMINATED LUPUS ERYTHEMATOSIS
SYNDROME LUPUS
Syst lupus erythematosus
SYSTEMIC LUPUS ERYTHEMATOSIS
Systemic lupus erythematosus (disorder)
Systemic lupus erythematosus (SLE)
Systemic lupus erythematosus NOS
Systemic lupus erythematosus synd
Systemic lupus erythematosus, unspecified
systemic lupus erythematosus

External Source Codes: 
NCI Thesaurus Code C3201 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN if not specified as "systemic" it is still probably correct to index here, not also discoid; LE CELLS see NEUTROPHILS is also available MSH
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Contributing_Source CTRP NCI
Contributing_Source NICHD NCI
CTV3ID N000. SNOMEDCT_US
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_FIRST_PUBLISHED 2008-07-30 PDQ
DATE_LAST_MODIFIED 2010-02-08 PDQ
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0729-7721 CSP
DISEASE_IDENTIFIER_ID 16923 GARD
DISEASE_IDENTIFIER_ID 16924 GARD
DISEASE_IDENTIFIER_ID 16928 GARD
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EXCLUDES1 lupus erythematosus (discoid) (NOS) (L93.0) ICD10CM
EXTERNALLY_DEFINED N LNC
FX D016682 MSH
FX D016736 MSH
FX D020293 MSH
GENELOCUS ,3,p,2,1,.,3,-,p,2,1,.,2, OMIM
GENESYMBOL AGS1 OMIM
GENESYMBOL CRV OMIM
GENESYMBOL HERNS OMIM
GENESYMBOL TREX1 OMIM
HPO_COMMENT This is a bundled term that describes a disease rather than a phenotypic feature, but is left for convenience for annotations of lupus conceived of as a feature of another disease. HPO
IAN DEFAULT ICD10
ICA Use additional code to identify manifestation, as: {endocarditis (424.91); nephritis (583.81) {chronic (582.81)}; nephrotic syndrome (581.81)} ICD9CM
ICE Disseminated lupus erythematosus; Libman-Sacks disease ICD9CM
IDENTIFIER_TYPE_ID 1 GARD
IS_ACTIVE true GARD
MDA 19990101 MSH
MESH_DEFINITION A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. NDFRT
MESH_DUI D008180 NDFRT
MESH_NAME Lupus Erythematosus, Systemic NDFRT
MESH_UI M0012757 NDFRT
MIMTYPE 3 OMIM
MIMTYPEMEANING Phenotype description, molecular basis known. OMIM
MIMTYPEVALUE pound OMIM
MMR 20130708 MSH
MN C17.300.480 MSH
MN C20.111.590 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NCI_THESAURUS_CODE C3201 PDQ
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Systemic Lupus Erythematosus NCI
NUI N0000001887 NDFRT
ORDER_NO 17944 ICD10CM
ORDER_NO 17955 ICD10CM
ORIG_STY Disease/diagnosis PDQ
PRIMARY_PATH 10042945$10025135$10010761$10028395$Systemic lupus erythematosus$Lupus erythematosus (incl subtypes)$Connective tissue disorders (excl congenital)$Musculoskeletal and connective tissue disorders MDR
PRIMARY_SOC 10028395 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RXAUI 3190324 RXNORM
RXAUI 3190336 RXNORM
RXAUI 3190337 RXNORM
RXAUI 3243224 RXNORM
RXCUI 1023595 RXNORM
SMQ_TERM_ADDVERSION 9.0 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 9.0 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 55464009 NDFRT
SOS Excludes: lupus erythematosus (discoid) NOS (695.4) ICD9CM
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS M32.9 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~M32.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS M32.9 | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~M32.9 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~N000. SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T024385 MSH
TERMUI T024386 MSH
TERMUI T024387 MSH
TH NLM (1966) MSH
TH NLM (1987) MSH
TH OMIM (2013) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0024141

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