skip navigation links
National Cancer Institute
Enterprise Vocabulary Services
Box
NCIm Version: 201706 (Browser Version 2.9, using LexEVS 6.5.1)
SearchBox Top
SearchBox Bottom
Liver Cirrhosis (CUI C0023890) Suggest changes to this concept
Add to Cart

Terms & Properties

Concept Unique Identifier (CUI): C0023890

NCI Thesaurus Code: C2951  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: A disorder characterized by replacement of the liver parenchyma with fibrous tissue and regenerative nodules. It is usually caused by alcoholism, hepatitis B, and hepatitis C. Complications include the development of ascites, esophageal varices, bleeding, and hepatic encephalopathy.

RADLEX Definition: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules. [MeSH]

HPO Definition: A chronic disorder of the liver in which liver tissue becomes scarred and is partially replaced by regenerative nodules and fibrotic tissue resulting in loss of liver function. [HPO:probinson]

MEDLINEPLUS Definition: 

Cirrhosis is scarring of the liver. Scar tissue forms because of injury or long-term disease. Scar tissue cannot do what healthy liver tissue does - make protein, help fight infections, clean the blood, help digest food and store energy. Cirrhosis can lead to

  • Easy bruising or bleeding, or nosebleeds
  • Swelling of the abdomen or legs
  • Extra sensitivity to medicines
  • High blood pressure in the vein entering the liver
  • Enlarged veins called varices in the esophagus and stomach. Varices can bleed suddenly.
  • Kidney failure
  • Jaundice
  • Severe itching
  • Gallstones

A small number of people with cirrhosis get liver cancer.

Your doctor will diagnose cirrhosis with blood tests, imaging tests, or a biopsy.

Cirrhosis has many causes. In the United States, the most common causes are chronic alcoholism and hepatitis. Nothing will make the scar tissue disappear, but treating the cause can keep it from getting worse. If too much scar tissue forms, you may need to consider a liver transplant.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases

NICHD Definition: A chronic degenerative disease of the liver characterized by parenchymal nodularity and fibrosis.

NCI-GLOSS Definition: A type of chronic, progressive liver disease in which liver cells are replaced by scar tissue.

CSP Definition: liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.

MSH Definition: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.

Synonyms & Abbreviations: (see Synonym Details)
Cirrhoses, Hepatic
Cirrhoses, Liver
Cirrhosis (of liver) NOS
CIRRHOSIS LIVER
Cirrhosis of liver (disorder)
CIRRHOSIS OF LIVER
Cirrhosis, Hepatic
Cirrhosis, Liver
cirrhosis
CL - Cirrhosis of liver
Hepatic Cirrhoses
Hepatic cirrhosis NOS
hepatic cirrhosis
Liver Cirrhoses
Liver Cirrhosis [Disease/Finding]
liver cirrhosis
Zirrhose

External Source Codes: 
NCI Thesaurus Code C2951 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Contributing_Source MedDRA NCI
Contributing_Source NICHD NCI
CTV3ID X307L SNOMEDCT_US
DATE_CREATED 07/08/1999 MEDLINEPLUS
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 1754-7664 CSP
DX 19600101 MSH
EFFECTIVE_TIME 20040731 SNOMEDCT_US
HN LIVER CIRRHOSIS, POSTNECROTIC was heading 1963-77 MSH
HPO_COMMENT Cirrhosis is caused by chronic liver disease as a result of viral infections (hepatitis), alcohol abuse, certain medications, certain metabolic disorders of iron and copper, and many others. Cirrhosis may lead to a number of abnormalities including hepatomegaly, jaundice, abnormal liver function tests, ascites, dilatation of veins in the abdominal wall, anemia, and clotting deficiencies. HPO
MDA 19990101 MSH
MESH_DEFINITION Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules. NDFRT
MESH_DUI D008103 NDFRT
MESH_NAME Liver Cirrhosis NDFRT
MESH_UI M0012636 NDFRT
MMR 20100625 MSH
MN C06.552.630 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
MODULE_ID 731000124108 SNOMEDCT_US
MODULE_NAME US National Library of Medicine maintained module SNOMEDCT_US
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/cirrhosis.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/cirrhosis.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Institute of Diabetes and Digestive and Kidney Diseases http://www.niddk.nih.gov/ MEDLINEPLUS
MSC Diagnosis.Term MTHMST
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Cirrhosis NCI
NUI N0000001862 NDFRT
OL use LIVER CIRRHOSIS to search LIVER CIRRHOSIS, POSTNECROTIC 1966-77 MSH
PM LIVER CIRRHOSIS, POSTNECROTIC was heading 1963-77 MSH
PRIMARY_PATH 10019641$10019669$10019654$10019805$Hepatic cirrhosis$Hepatic fibrosis and cirrhosis$Hepatic and hepatobiliary disorders$Hepatobiliary disorders MDR
PRIMARY_SOC 10019805 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
REF HPO:skoehler HPO
RXAUI 3133643 RXNORM
RXAUI 3172139 RXNORM
RXAUI 3189940 RXNORM
RXAUI 3189941 RXNORM
RXCUI 1024193 RXNORM
SMQ_TERM_ADDVERSION 10.1 MDR
SMQ_TERM_ADDVERSION 8.0 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 12.1 MDR
SMQ_TERM_LMVERSION 19.0 MDR
SMQ_TERM_SCOPE 1 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_STATUS I MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 19943007 NDFRT
SNOMEDID D5-80600 SNOMEDCT_US
SOS A disease characterized by fibrosis, nodules, and loss of the normal structure of the liver accompanied by decline in liver function. AOD
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS K74.6 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~K74.6 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS K74.60 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~K74.60 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~X307L SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~D5-80600 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T024183 MSH
TERMUI T024184 MSH
TERMUI T024185 MSH
TH NLM (1963) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0023890

Mainbox Bottom