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Levodopa (CUI C0023570) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0023570

NCI Thesaurus Code: C611  (see NCI Thesaurus info)

Semantic Type: Biologically Active Substance

Semantic Type: Amino Acid, Peptide, or Protein

Semantic Type: Pharmacologic Substance

NCIt Definition: An amino acid precursor of dopamine with antiparkinsonian properties. Levodopa is a prodrug that is converted to dopamine by DOPA decarboxylase and can cross the blood-brain barrier. When in the brain, levodopa is decarboxylated to dopamine and stimulates the dopaminergic receptors, thereby compensating for the depleted supply of endogenous dopamine seen in Parkinson's disease. To assure that adequate concentrations of levodopa reach the central nervous system, it is administered with carbidopa, a decarboxylase inhibitor that does not cross the blood-brain barrier, thereby diminishing the decarboxylation and inactivation of levodopa in peripheral tissues and increasing the delivery of dopamine to the CNS.

PDQ Definition: An amino acid precursor of dopamine with antiparkinsonian properties. Levodopa is a prodrug that is converted to dopamine by DOPA decarboxylase and can cross the blood-brain barrier. When in the brain, levodopa is decarboxylated to dopamine and stimulates the dopaminergic receptors, thereby compensating for the depleted supply of endogenous dopamine seen in Parkinson's disease. To assure that adequate concentrations of levodopa reach the central nervous system, it is administered with carbidopa, a decarboxylase inhibitor that does not cross the blood-brain barrier, thereby diminishing the decarboxylation and inactivation of levodopa in peripheral tissues and increasing the delivery of dopamine to the CNS. Check for active clinical trials using this agent. (NCI Thesaurus)

CSP Definition: naturally occuring form of DOPA and precursor of dopamine; used as an antiparkinsonian agent; unlike dopamine it can be administered orally.

MSH Definition: The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to DOPAMINE. It is used for the treatment of PARKINSONIAN DISORDERS and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system.

Synonyms & Abbreviations: (see Synonym Details)
(-)-3-(3,4-Dihydroxyphenyl)-L-alanine
(-)-Dopa
(--)-2Amino-3-(3,4-dihydroxyphenyl)propanoic Acid
(--)-2amino-3-)3,4-dihydroxyphenyl)propanoic acid
(--)-3-(3,4-Dihydroxyphenyl)-L-alanine
.beta.-(3,4-Dihydroxyphenyl)-L-alanine
118381
3 Hydroxy L tyrosine
3,4-Dihydroxy-L-phenylalanine
3,4-DIHYDROXYPHENYLALANINE
3-(3,4-Dihydroxyphenyl)-L-alanine
3-Hydroxy-L-tyrosine
Bendopa
beta-(3,4-Dihydroxyphenyl)-L-alanine
beta-(3,4-Dihydroxyphenyl)alanine
Cidandopa
Deadopa
Dihydroxy-L-phenylalanine
DOPA A L
Dopaflex
Dopaidan
Dopalina
Dopal
Doparkine
Doparl
Dopar
Dopasol
Dopaston
Dopastral
Doprin
Eldopal
Eldopar
Eldopatec
Eurodopa
L 3,4 Dihydroxyphenylalanine
L 3,4-dihydroxyphenylalanine
L Dopa
L(-)-Dopa
L-.beta.-(3,4-Dihydroxyphenyl)alanine
L-3,4-dihydroxyphenylalanine
L-3-hydroxytyrosine
L-beta-(3,4-Dihydroxyphenyl)alanine
L-dopa - Levodopa
L-dopa
Laradopa
larodopa
Ledopa
Levodopa (substance)
Levodopa [Chemical/Ingredient]
levodopa
Levodopum
levopa
Maipedopa
Parda
Product containing levodopa (medicinal product)
Product containing levodopa
Veldopa
β-(3,4-dihydroxyphenyl)alanine

External Source Codes: 
NCI Thesaurus Code C611 (see NCI Thesaurus info)
CAS Registry Number 59-92-7 (see NLM ChemIDplus info)
FDA UNII Code 46627O600J
NSC Code 118381 (see NCI DTP info)
PDQ Closed Trial Search ID 42622
PDQ Open Trial Search ID 42622 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BI BL CF CH CL CS CT DF EC GE HI IM IP ME PD PH PK PO RE SD SE ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:15765 NCI
Chemical_Formula C9H11NO4 NCI
Contributing_Source FDA NCI
CTV3ID dq1.. SNOMEDCT_US
CTV3ID XUWqg SNOMEDCT_US
DATE_LAST_MODIFIED 2006-12-27 PDQ
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 5000-0053 CSP
DX 19750101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20030131 SNOMEDCT_US
FDA_UNII_CODE 46627O600J DRUGBANK
FDA_UNII_CODE 46627O600J NDFRT
FX D004298 MSH
HN 75; was see DOPA 1972-74 MSH
LEVEL Ingredient NDFRT
LT TRD MSH
LT TRD MTH
LT TRD PDQ
MDA 19990101 MSH
MESH_DEFINITION The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to DOPAMINE. It is used for the treatment of PARKINSONIAN DISORDERS and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system. NDFRT
MESH_DUI D007980 NDFRT
MESH_NAME Levodopa NDFRT
MESH_UI M0012434 NDFRT
MMR 20160701 MSH
MN D02.092.311.200.480 MSH
MN D12.125.072.050.685.400.500 MSH
MN D12.125.072.050.875.130.500 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NCI_THESAURUS_CODE C611 PDQ
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006700 NDFRT
NUI N0000146151 NDFRT
OL search DOPA 1972-74 MSH
ORIG_STY Drug/agent PDQ
PA D000978 MSH
PA D015259 MSH
PID 6342 PDQ
PM 75; was see DOPA 1972-74 MSH
RN 0 MSH
RN 46627O600J MSH
RXAUI 1137365 RXNORM
RXAUI 1177486 RXNORM
RXAUI 206099 RXNORM
RXAUI 2072047 RXNORM
RXAUI 2629492 RXNORM
RXAUI 2653154 RXNORM
RXAUI 3022058 RXNORM
RXAUI 3093218 RXNORM
RXAUI 3185152 RXNORM
RXAUI 3185211 RXNORM
RXAUI 3186373 RXNORM
RXAUI 3186374 RXNORM
RXAUI 3189358 RXNORM
RXAUI 3189359 RXNORM
RXCUI 202990 RXNORM
RXCUI 216725 RXNORM
RXCUI 6375 RXNORM
RXN_BN_CARDINALITY single RXNORM
RXN_OBSOLETED 03/27/2013 RXNORM
SID APRD00309 DRUGBANK
SID EXPT01107 DRUGBANK
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SPL_SET_ID ed11ba39-2ec3-4926-bc00-000065515d26 MTHSPL
SPL_SET_ID eeb20562-3b70-4c3c-a28a-fa8b657c9413 MTHSPL
SPL_SET_ID ef35e299-f244-4ff8-be75-6362290a4251 MTHSPL
SPL_SET_ID f075a58f-2977-44b4-838d-a24ae0bc550c MTHSPL
SPL_SET_ID f13a92ec-bb94-4ebd-acaa-b9ad14d67cac MTHSPL
SPL_SET_ID f1a334d2-129c-49f9-bd29-6bb0838085fe MTHSPL
SPL_SET_ID f1d6c0c3-6bff-4ea2-bcf8-0d679b5ccc6d MTHSPL
SPL_SET_ID fd6d7db6-ccbd-4e4c-bee4-0a4777b476e2 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~dq1.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUWqg SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T023781 MSH
TERMUI T023782 MSH
TERMUI T023783 MSH
TERMUI T023784 MSH
TERMUI T023785 MSH
TERMUI T023786 MSH
TERMUI T580140 MSH
TERMUI T580142 MSH
TH DE MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH NLM (1995) MSH
TH UNK (19XX) MSH
TH USAN (1969) MSH
TH USP (19XX) MSH
TH US MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^385^Active/Master NDFRT
VANDF_RECORD 50.6^160^Active/Master NDFRT
VUID 4017790 NDFRT

Additional Concept Data:  (none)

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