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Myeloid Leukemia, Chronic (CUI C0023473) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0023473

NCI Thesaurus Code: C3174  (see NCI Thesaurus info)

Semantic Type: Neoplastic Process

NCIt Definition: A chronic myeloproliferative neoplasm characterized by the expression of the BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear at any age, but it mostly affects middle aged and older individuals. Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. If untreated, it follows a biphasic or triphasic natural course; an initial indolent chronic phase which is followed by an accelerated phase, a blast phase, or both. Allogeneic stem cell transplantation and tyrosine kinase inhibitors delay disease progression and prolong overall survival.

PDQ Definition: The most common chronic myeloproliferative disorder characterized by neutrophilic leukocytosis. It is associated with the Philadelphia (Ph) chromosome and/or the BCR/ABL fusion gene. Most patients are middle-aged or elderly. Common findings at presentation include fatigue, weight loss, anemia, night sweats, and splenomegaly. The disease is bi- or triphasic; an initial indolent chronic phase is followed by an accelerated or blast phase. Allogeneic bone marrow transplantation is currently the only curative therapy (adapted from WHO 2001). Check for active clinical trials using this agent. (NCI Thesaurus)

HPO Definition: A myeloproliferative disorder characterized by increased proliferation of the granulocytic cell line without the loss of their capacity to differentiate. [HPO:probinson]

MEDLINEPLUS Definition: 

Leukemia is cancer of the white blood cells. White blood cells help your body fight infection. Your blood cells form in your bone marrow. In leukemia, the bone marrow produces abnormal white blood cells. These cells crowd out the healthy blood cells, making it hard for blood to do its work. In chronic myeloid leukemia (CML), there are too many granulocytes, a type of white blood cell.

Most people with CML have a gene mutation (change) called the Philadelphia chromosome.

Sometimes CML does not cause any symptoms. If you have symptoms, they may include:

  • Fatigue
  • Weight loss
  • Night sweats
  • Fever
  • Pain or a feeling of fullness below the ribs on the left side

Tests that examine the blood and bone marrow diagnose CML. Treatments include chemotherapy, stem cell transplants, infusion of donated white blood cells following stem cell transplants, surgery to remove the spleen, and biologic and targeted therapies. Biologic therapy boosts your body's own ability to fight cancer. Targeted therapy uses substances that attack cancer cells without harming normal cells.

NIH: National Cancer Institute

NCI-GLOSS Definition: A slowly progressing disease in which too many white blood cells are made in the bone marrow.

CSP Definition: chronic leukemia in which myeloid progenitor cells predominate; the hallmark of CML, the Philadelphia chromosome, is a reciprocal translocation between chromosomes 9 and 22 which activates the proto- oncogene c-abl.

MSH Definition: Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.

Synonyms & Abbreviations: (see Synonym Details)
BCR-ABL Positive Chronic Myelogenous Leukemia
CGL - Chronic granulocytic leukaemia
CGL - Chronic granulocytic leukemia
CGL
Chronic granulocytic leukaemia
Chronic granulocytic leukemia, NOS
Chronic Granulocytic Leukemias
CHRONIC GRANULOCYTIC LEUKEMIA
Chronic myelocytic leukaemia
Chronic myelocytic leukemia, NOS
Chronic Myelocytic Leukemias
chronic myelocytic leukemia
Chronic myelogenous leukaemia
Chronic myelogenous leukemia (CML)
Chronic Myelogenous Leukemia, BCR-ABL1 Positive
Chronic myelogenous leukemia, BCR/ABL positive
Chronic myelogenous leukemia, no ICD-O subtype
Chronic myelogenous leukemia, no International Classification of Diseases for Oncology subtype (morphologic abnormality)
Chronic myelogenous leukemia, no International Classification of Diseases for Oncology subtype
Chronic myelogenous leukemia, NOS
Chronic myelogenous leukemia, t(9;22)(q34;11)
Chronic Myelogenous Leukemias
chronic myelogenous leukemia
Chronic myeloid leukaemia, disease
Chronic myeloid leukaemia
Chronic myeloid leukemia (all subtypes)
Chronic myeloid leukemia, disease (disorder)
Chronic myeloid leukemia, disease
Chronic myeloid leukemia, NOS
Chronic Myeloid Leukemias
chronic myeloid leukemia
CML - Chronic Myelogenous Leukemia
CML - Chronic myeloid leukaemia
CML - Chronic myeloid leukemia
CML
Granulocytic Leukemia, Chronic
Granulocytic Leukemias, Chronic
Hematopoeitic - Chronic Myelocytic Leukemia (CML)
Leukaemia myelocytic chronic
Leukaemias chronic myeloid
LEUKEMIA CHRONIC MYELOCYTIC
LEUKEMIA MYELOCYTIC CHRONIC
LEUKEMIA PHILA POS
Leukemia, Chronic Granulocytic
Leukemia, Chronic Myelocytic
Leukemia, chronic myelogenous (CML)
Leukemia, Chronic Myelogenous
Leukemia, chronic myeloid
LEUKEMIA, GRANULOCYTIC, CHRONIC
LEUKEMIA, MYELOCYTIC, CHRONIC
Leukemia, Myelogenous, Chronic, BCR-ABL Positive [Disease/Finding]
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
LEUKEMIA, MYELOGENOUS, CHRONIC
Leukemia, Myelogenous, Ph1 Positive
Leukemia, Myelogenous, Ph1-Positive
LEUKEMIA, MYELOID, CHRONIC
Leukemia, Myeloid, Ph1 Positive
Leukemia, Myeloid, Ph1-Positive
Leukemia, Myeloid, Philadelphia Positive
Leukemia, Myeloid, Philadelphia-Positive
Leukemia, Ph1-Positive Myelogenous
Leukemia, Ph1-Positive Myeloid
Leukemia, Philadelphia-Positive Myeloid
Leukemias chronic myeloid
Leukemias, Chronic Granulocytic
Leukemias, Chronic Myelocytic
Leukemias, Chronic Myelogenous
Leukemias, Chronic Myeloid
Leukemias, Ph1-Positive Myelogenous
Leukemias, Ph1-Positive Myeloid
Leukemias, Philadelphia-Positive Myeloid
Myelocytic Leukemia, Chronic
Myelocytic Leukemias, Chronic
Myelogenous Leukemia, Chronic
Myelogenous Leukemia, Ph1 Positive
Myelogenous Leukemia, Ph1-Positive
Myelogenous Leukemias, Chronic
Myelogenous Leukemias, Ph1-Positive
Myeloid leukaemia, chronic
Myeloid leukemia, chronic
Myeloid Leukemia, Ph1 Positive
Myeloid Leukemia, Ph1-Positive
Myeloid Leukemia, Philadelphia Positive
Myeloid Leukemia, Philadelphia-Positive
Myeloid Leukemias, Chronic
Myeloid Leukemias, Ph1-Positive
Myeloid Leukemias, Philadelphia-Positive
Ph1-Positive Myelogenous Leukemias
Ph1-Positive Myelogenous Leukemia
Ph1-Positive Myeloid Leukemias
Ph1-Positive Myeloid Leukemia
Philadelphia-Positive Myeloid Leukemias
Philadelphia-Positive Myeloid Leukemia

External Source Codes: 
NCI Thesaurus Code C3174 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Contributing_Source CTRP NCI
CTV3ID B651. SNOMEDCT_US
CTV3ID BBr63 SNOMEDCT_US
DATE_CREATED 10/12/2010 MEDLINEPLUS
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_LAST_MODIFIED 2004-12-21 PDQ
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2004-1700 CSP
DISEASE_IDENTIFIER_ID 17879 GARD
DISEASE_IDENTIFIER_ID 17880 GARD
DISEASE_IDENTIFIER_ID 17881 GARD
DISEASE_IDENTIFIER_ID 17882 GARD
DX 19890101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
GENELOCUS ,2,2,q,1,1,.,2,1, OMIM
GENESYMBOL ALL OMIM
GENESYMBOL BCR OMIM
GENESYMBOL CML OMIM
GENESYMBOL PHL OMIM
HAS_GARD_PAGE true GARD
HN 2008 (1989); for LEUKEMIA, MYELOCYTIC, CHRONIC & LEUKEMIA, MYELOGENOUS, CHRONIC use LEUKEMIA, MYELOID 1974-1988 MSH
ICD-O-3_Code 9863/3 NCI
ICD-O-3_Code 9875/3 NCI
ICD-O-3_CODE 9863/3 SNOMEDCT_US
ICE Eosinophilic leukemia; Neutrophilic leukemia ICD9CM
IDENTIFIER_TYPE_ID 1 GARD
IS_ACTIVE true GARD
IS_RARE true GARD
IS_SPANISH false GARD
LAST_REVIEW_DATE 2009-11-10T00:00:00 GARD
MDA 19880609 MSH
MESH_DEFINITION Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS. NDFRT
MESH_DUI D015464 NDFRT
MESH_NAME Leukemia, Myelogenous, Chronic, BCR-ABL Positive NDFRT
MESH_UI M0023821 NDFRT
MIMTYPE 3 OMIM
MIMTYPEMEANING Phenotype description, molecular basis known. OMIM
MIMTYPEVALUE pound OMIM
MMR 20120703 MSH
MN C04.557.337.539.250 MSH
MN C15.378.190.636.370 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/chronicmyeloidleukemia.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/chronicmyeloidleukemia.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Cancer Institute http://www.nci.nih.gov/ MEDLINEPLUS
NCI_THESAURUS_CODE C3174 PDQ
NDFRT_KIND DISEASE_KIND NDFRT
Neoplastic_Status Malignant NCI
NUI N0000003261 NDFRT
ORIG_STY Cancer stage PDQ
ORIG_STY Neoplasm diagnosis PDQ
PID 1031 PDQ
PM 2008; see LEUKEMIA, MYELOID, CHRONIC 1989-2007; for LEUKEMIA, MYELOID, PHILADELPHIA-POSITIVE see LEUKEMIA, MYELOID, PHILADELPHIA-POSITIVE 1989-2007; for LEUKEMIA, MYELOCYTIC, CHRONIC & LEUKEMIA, MYELOGENOUS, CHRONIC see LEUKEMIA, MYELOCYTIC 1974-1988 MSH
PRIMARY_PATH 10009013$10024296$10024324$10029104$Chronic myeloid leukaemia$Leukaemias chronic myeloid$Leukaemias$Neoplasms benign, malignant and unspecified (incl cysts and polyps) MDR
PRIMARY_SOC 10029104 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/6105/chronic-myeloid-leukemia/resources/1 GARD
RXAUI 3166871 RXNORM
RXAUI 3188871 RXNORM
RXAUI 3188951 RXNORM
RXAUI 3188956 RXNORM
RXAUI 3200614 RXNORM
RXAUI 3200632 RXNORM
RXAUI 3200667 RXNORM
RXAUI 3287796 RXNORM
RXAUI 3287797 RXNORM
RXAUI 3287799 RXNORM
RXAUI 3287801 RXNORM
RXAUI 3287807 RXNORM
RXAUI 3287812 RXNORM
RXAUI 3287814 RXNORM
RXAUI 3287816 RXNORM
RXAUI 3287818 RXNORM
RXAUI 3288077 RXNORM
RXAUI 3288080 RXNORM
RXAUI 3288082 RXNORM
RXAUI 5039580 RXNORM
RXAUI 5039581 RXNORM
RXCUI 1021752 RXNORM
SID HP:0005544 HPO
SMQ_TERM_ADDVERSION 10.0 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 20.0 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 92818009 NDFRT
SNOMEDID DC-F4243 SNOMEDCT_US
SNOMEDID M-98633 SNOMEDCT_US
SUBSET_MEMBER 446608001~MAPTARGET~9863/3 SNOMEDCT_US
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS C92.1 | POSSIBLE REQUIREMENT FOR MORPHOLOGY CODE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~C92.1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS C92.Z0 | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~C92.Z0 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~B651. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~BBr63 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~DC-F4243 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~M-98633 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERM_LEVEL 4 ICDO
TERM_LEVEL Synonym ICDO
TERMUI T045739 MSH
TERMUI T045740 MSH
TERMUI T045741 MSH
TERMUI T045742 MSH
TERMUI T045743 MSH
TERMUI T045744 MSH
TERMUI T045745 MSH
TERMUI T045746 MSH
TERMUI T045784 MSH
TERMUI T045785 MSH
TERMUI T045786 MSH
TERMUI T045787 MSH
TERMUI T045788 MSH
TERMUI T045789 MSH
TERMUI T045790 MSH
TERMUI T045791 MSH
TERMUI T045792 MSH
TERMUI T689284 MSH
TERMUI T811699 MSH
TERMUI T811700 MSH
TH NLM (1988) MSH
TH NLM (1989) MSH
TH NLM (2008) MSH
TH OMIM (2013) MSH
TH ORD (2010) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0023473

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