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Acute Myeloid Leukemia (CUI C0023467) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0023467

NCI Thesaurus Code: C3171  (see NCI Thesaurus info)

Semantic Type: Neoplastic Process

NCIt Definition: A clonal expansion of myeloid blasts in the bone marrow, blood or other tissues. The classification of acute myeloid leukemias (AMLs) encompasses four major categories: 1) AML with recurrent genetic abnormalities; 2) AML with multilineage dysplasia; 3) Therapy-related AML; 4) AML not otherwise specified. The required bone marrow or peripheral blood blast percentage for the diagnosis of AML is 20% (WHO classification).

PDQ Definition: A clonal expansion of myeloid blasts in the bone marrow, blood or other tissues. The classification of acute myeloid leukemias (AMLs) encompasses four major categories: 1) AML with recurrent genetic abnormalities 2) AML with multilineage dysplasia 3) Therapy-related AML 4) AML not otherwise categorized. The required bone marrow or peripheral blood blast percentage for the diagnosis of AML has been recently reduced from 30% (French-American-British [FAB] classification) to 20% (WHO classification). (WHO, 2001) Check for active clinical trials using this agent. (NCI Thesaurus)

HPO Definition: A form of leukemia characterized by overproduction of an early myeloid cell. [HPO:probinson]

MEDLINEPLUS Definition: 

Leukemia is cancer of the white blood cells. White blood cells help your body fight infection. Your blood cells form in your bone marrow. In leukemia, however, the bone marrow produces abnormal white blood cells. These cells crowd out the healthy blood cells, making it hard for blood to do its work. In acute myeloid leukemia (AML), there are too many of a specific type of white blood cell called a myeloblast.

AML is the most common type of acute leukemia in adults. This type of cancer usually gets worse quickly if it is not treated. Possible risk factors include smoking, previous chemotherapy treatment, and exposure to radiation.

Symptoms of AML include:

  • Fever
  • Shortness of breath
  • Easy bruising or bleeding
  • Bleeding under the skin
  • Weakness or feeling tired
  • Weight loss or loss of appetite

Tests that examine the blood and bone marrow diagnose AML. Treatments include chemotherapy, other drugs, radiation therapy, stem cell transplants, and targeted therapy. Targeted therapy uses substances that attack cancer cells without harming normal cells. Once the leukemia is in remission, you need additional treatment to make sure that it does not come back.

NIH: National Cancer Institute

NICHD Definition: A rapidly progressive cancer of the blood and bone marrow consisting of the proliferation of abnormal myeloblasts, which are immature, dysfunctional white blood cells.

NCI-GLOSS Definition: An aggressive (fast-growing) disease in which too many myeloblasts (immature white blood cells that are not lymphoblasts) are found in the bone marrow and blood.

CTEP Definition: CTEP_For_FDA: 10000884/Acute myeloid leukemia NOS

CSP Definition: leukemia commonly occurring after alkylating agent treatment; manifestations include pancytopenia, megaloblastic bone marrow, and nucleated red cells in peripheral marrow; patients usually have chromosomal abnormalities in marrow cells.

CSP Definition: acute leukemia arising from myeloid tissue in which the granular, polymorphonuclear leukocytes and their precursors predominate.

MSH Definition: Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.

Synonyms & Abbreviations: (see Synonym Details)
Acute granulocytic leukaemia
acute granulocytic leukemia
Acute megakaryocytic leukemia
Acute myeloblastic leukaemia [AML]
Acute myeloblastic leukaemia
Acute myeloblastic leukemia [AML]
Acute myeloblastic leukemia NOS
Acute Myeloblastic Leukemias
acute myeloblastic leukemia
Acute myelocytic leukaemia
Acute Myelocytic Leukemias
acute myelocytic leukemia
Acute myelogenous leukaemia
Acute Myelogenous Leukemias
ACUTE MYELOGENOUS LEUKEMIA
Acute myeloid leukaemia - category
Acute myeloid leukaemia NOS
Acute myeloid leukaemia, disease
Acute myeloid leukaemia, no ICD-O subtype
Acute myeloid leukaemia
Acute myeloid leukemia (all subtypes)
Acute Myeloid Leukemia (AML)
Acute myeloid leukemia - category (morphologic abnormality)
Acute myeloid leukemia - category
Acute myeloid leukemia NOS
Acute myeloid leukemia, disease (disorder)
Acute myeloid leukemia, disease
Acute myeloid leukemia, no ICD-O subtype
Acute myeloid leukemia, no International Classification of Diseases for Oncology subtype (morphologic abnormality)
Acute myeloid leukemia, no International Classification of Diseases for Oncology subtype
Acute myeloid leukemia, NOS
Acute Myeloid Leukemias
acute myeloid leukemia
Acute non lymphoblastic leukemia
Acute non-lymphocytic leukaemia
Acute non-lymphocytic leukemia
Acute Nonlymphoblastic Leukemias
Acute Nonlymphoblastic Leukemia
Acute Nonlymphocytic Leukemias
acute nonlymphocytic leukemia
AML - Acute myeloblastic leukaemia
AML - Acute myeloblastic leukemia
AML - Acute myeloid leukaemia
AML - Acute Myeloid Leukemia
AML
ANLL
Hematopoeitic - Acute Myleogenous Leukemia (AML)
Leukaemia myeloblastic acute
Leukaemias acute myeloid
LEUKEMIA ACUTE MYELOBLASTIC
Leukemia acute myelogenous
LEUKEMIA MYELOBLASTIC ACUTE
Leukemia, Acute Myeloblastic
Leukemia, Acute Myelocytic
Leukemia, Acute Myelogenous
Leukemia, Acute Myeloid
Leukemia, Acute Nonlymphoblastic
Leukemia, Acute Nonlymphocytic
LEUKEMIA, GRANULOCYTIC, ACUTE
LEUKEMIA, MYELOBLASTIC, ACUTE
LEUKEMIA, MYELOCYTIC, ACUTE
LEUKEMIA, MYELOGENOUS, ACUTE
Leukemia, Myeloid, Acute [Disease/Finding]
LEUKEMIA, MYELOID, ACUTE
Leukemia, Nonlymphoblastic, Acute
Leukemia, Nonlymphocytic, Acute
Leukemias acute myeloid
Leukemias, Acute Myeloblastic
Leukemias, Acute Myelocytic
Leukemias, Acute Myelogenous
Leukemias, Acute Myeloid
Leukemias, Acute Nonlymphoblastic
Leukemias, Acute Nonlymphocytic
Myeloblastic Leukemia, Acute
Myeloblastic Leukemias, Acute
Myelocytic Leukemia, Acute
Myelocytic Leukemias, Acute
Myelogenous Leukemia, Acute
Myelogenous Leukemias, Acute
Myeloid leukaemia, acute
Myeloid leukemia, acute
Myeloid Leukemias, Acute
Non-lymphoblastic leukaemia acute
Non-lymphoblastic leukemia acute
Nonlymphoblastic Leukemia, Acute
Nonlymphoblastic Leukemias, Acute
Nonlymphocytic Leukemia, Acute
Nonlymphocytic Leukemias, Acute

External Source Codes: 
NCI Thesaurus Code C3171 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN general or unspecified: prefer specifics MSH
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Contributing_Source CTRP NCI
Contributing_Source MedDRA NCI
Contributing_Source NICHD NCI
CTV3ID B650. SNOMEDCT_US
CTV3ID BBr61 SNOMEDCT_US
CTV3ID XUcUD SNOMEDCT_US
DATE_CREATED 10/12/2010 MEDLINEPLUS
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_CREATED 2015-01-22T00:04:00 GARD
DATE_LAST_MODIFIED 2012-03-21 PDQ
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 4000-0108 CSP
DID 4001-0002 CSP
DISEASE_IDENTIFIER_ID 33233 GARD
DISEASE_IDENTIFIER_ID 33234 GARD
DISEASE_IDENTIFIER_ID 6752 GARD
DISEASE_IDENTIFIER_ID 6753 GARD
DISEASE_IDENTIFIER_ID 6754 GARD
DISEASE_IDENTIFIER_ID 6755 GARD
DX 19890101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20050131 SNOMEDCT_US
EXCLUDES1 acute exacerbation of chronic myeloid leukemia (C92.10) ICD10CM
EXCLUDES1 refractory anemia with excess of blasts not in transformation (D46.2-) ICD10CM
GENELOCUS ,8,p,1,2, OMIM
GENESYMBOL NSD3 OMIM
GENESYMBOL WHSC1L1 OMIM
HAS_GARD_PAGE true GARD
HN 2008 (1989) MSH
IAN DEFAULT ICD10
ICD-O-3_Code 9861/3 NCI
ICD-O-3_CODE 9861/3 SNOMEDCT_US
ICE Acute promyelocytic leukemia ICD9CM
IDENTIFIER_SOURCE Orp GARD
IDENTIFIER_TYPE_ID 1 GARD
INCLUSION_TERM Acute myeloblastic leukaemia (with maturation) ICD10
INCLUSION_TERM Acute myeloblastic leukaemia, minimal differentiation ICD10
INCLUSION_TERM AML (without a FAB classification) NOS ICD10
INCLUSION_TERM AML M0 ICD10
INCLUSION_TERM AML M1 ICD10
INCLUSION_TERM AML M2 ICD10
INCLUSION_TERM AML with t(8;21) ICD10
INCLUSION_TERM AML1/ETO ICD10
INCLUSION_TERM Refractory anaemia with excess blasts in transformation ICD10
IS_ACTIVE true GARD
IS_RARE true GARD
IS_SPANISH false GARD
MDA 19880609 MSH
MESH_DEFINITION Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES. NDFRT
MESH_DUI D015470 NDFRT
MESH_NAME Leukemia, Myeloid, Acute NDFRT
MESH_UI M0023827 NDFRT
MIMTYPE 3 OMIM
MIMTYPEMEANING Phenotype description, molecular basis known. OMIM
MIMTYPEVALUE pound OMIM
MMR 20120703 MSH
MN C04.557.337.539.275 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
MOVED_FROM 602439 OMIM
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/acutemyeloidleukemia.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/acutemyeloidleukemia.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Cancer Institute http://www.nci.nih.gov/ MEDLINEPLUS
NCI_THESAURUS_CODE C3171 PDQ
NDFRT_KIND DISEASE_KIND NDFRT
Neoplastic_Status Malignant NCI
NICHD_Hierarchy_Term Acute Myeloid Leukemia NCI
NUI N0000003267 NDFRT
ORDER_NO 02622 ICD10CM
ORIG_STY Neoplasm diagnosis PDQ
PID 818 PDQ
PM 2008; see LEUKEMIA, NONLYMPHOCYTIC, ACUTE 1989-2007 MSH
PRIMARY_PATH 10000880$10024291$10024324$10029104$Acute myeloid leukaemia$Leukaemias acute myeloid$Leukaemias$Neoplasms benign, malignant and unspecified (incl cysts and polyps) MDR
PRIMARY_SOC 10029104 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/537/acute-non-lymphoblastic-leukemia/resources/1 GARD
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/5734/acute-myelocytic-leukemia/resources/1 GARD
RXAUI 3101519 RXNORM
RXAUI 3189003 RXNORM
RXAUI 3207459 RXNORM
RXAUI 3207461 RXNORM
RXAUI 3286634 RXNORM
RXAUI 3287793 RXNORM
RXAUI 3287794 RXNORM
RXAUI 3287795 RXNORM
RXAUI 3287804 RXNORM
RXAUI 3287805 RXNORM
RXAUI 3287821 RXNORM
RXAUI 3288070 RXNORM
RXAUI 3288071 RXNORM
RXAUI 3288075 RXNORM
RXAUI 3288078 RXNORM
RXAUI 5038603 RXNORM
RXAUI 5039574 RXNORM
RXAUI 5039575 RXNORM
RXCUI 1022145 RXNORM
SEE_ALSO (see also M-9930/3) ICDO
SID HP:0001914 HPO
SID HP:0004843 HPO
SID HP:0005516 HPO
SID HP:0006724 HPO
SID HP:0006728 HPO
SMQ_TERM_ADDVERSION 10.0 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 20.0 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 17788007 NDFRT
SNOMED_CID 413443009 NDFRT
SNOMED_CID 91861009 NDFRT
SOS Excludes: acute exacerbation of chronic myeloid leukemia (205.1) ICD9CM
SUBSET_MEMBER 446608001~MAPTARGET~9861/3 SNOMEDCT_US
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS C92.0 | POSSIBLE REQUIREMENT FOR MORPHOLOGY CODE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~C92.0 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS C92.00 | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~C92.00 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~B650. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~BBr61 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUcUD SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERM_LEVEL 4 ICDO
TERM_LEVEL Synonym ICDO
TERMUI T023686 MSH
TERMUI T023687 MSH
TERMUI T023688 MSH
TERMUI T023689 MSH
TERMUI T023690 MSH
TERMUI T023691 MSH
TERMUI T045793 MSH
TERMUI T045794 MSH
TERMUI T045795 MSH
TERMUI T045796 MSH
TERMUI T045797 MSH
TERMUI T689231 MSH
TERMUI T689232 MSH
TERMUI T689277 MSH
TERMUI T811696 MSH
TERMUI T811697 MSH
TERMUI T811698 MSH
TH NLM (1967) MSH
TH NLM (1989) MSH
TH NLM (2008) MSH
TH NLM (2013) MSH
TH OMIM (2013) MSH
TH ORD (2010) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0023467

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