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Acute Lymphoblastic Leukemia (CUI C0023449) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0023449

NCI Thesaurus Code: C3167  (see NCI Thesaurus info)

Semantic Type: Neoplastic Process

NCIt Definition: Leukemia with an acute onset, characterized by the presence of lymphoblasts in the bone marrow and the peripheral blood. It includes the acute B lymphoblastic leukemia and acute T lymphoblastic leukemia.

PDQ Definition: Leukemia with an acute onset, characterized by the presence of lymphoblasts in the bone marrow and the peripheral blood. It includes the precursor B lymphoblastic leukemia and precursor T lymphoblastic leukemia. Check for active clinical trials using this agent. (NCI Thesaurus)

HPO Definition: A form of acute leukemia characterized by excess lympoblasts. [HPO:probinson]

MEDLINEPLUS Definition: 

Leukemia is cancer of the white blood cells. White blood cells help your body fight infection. Your blood cells form in your bone marrow. In leukemia, however, the bone marrow produces abnormal white blood cells. These cells crowd out the healthy blood cells, making it hard for blood to do its work. In acute lymphocytic leukemia (ALL), also called acute lymphoblastic leukemia, there are too many of specific types of white blood cells called lymphocytes or lymphoblasts. ALL is the most common type of cancer in children.

Possible risk factors for ALL include being male, being white, previous chemotherapy treatment, exposure to radiation, and for adults, being older than 70.

Symptoms of ALL include:

  • Weakness or feeling tired
  • Fever
  • Easy bruising or bleeding
  • Bleeding under the skin
  • Shortness of breath
  • Weight loss or loss of appetite
  • Pain in the bones or stomach
  • Pain or a feeling of fullness below the ribs
  • Painless lumps in the neck, underarm, stomach, or groin

Tests that examine the blood and bone marrow diagnose ALL. Treatments include chemotherapy, radiation therapy, stem cell transplants, and targeted therapy. Targeted therapy uses substances that attack cancer cells without harming normal cells. Once the leukemia is in remission, you need additional treatment to make sure that it does not come back.

NIH: National Cancer Institute

NICHD Definition: A rapidly progressive cancer of the blood and bone marrow consisting of the proliferation of lymphoblasts, which are immature, dysfunctional white blood cells.

NCI-GLOSS Definition: An aggressive (fast-growing) type of leukemia (blood cancer) in which too many lymphoblasts (immature white blood cells) are found in the blood and bone marrow.

CDISC Definition: A progressive, proliferative disease of blood cells, originating from immature lymphoid cells.

CTEP Definition: CTEP_For_FDA: 10000846/Acute lymphocytic leukemia

CSP Definition: acute leukemia in which lymphoblasts and their progenitor cells predominate; the most common childhood cancer and accounts for 20 percent of adult acute leukemia; common ALL antigen (CALLA) expressed in most cases.

MSH Definition: A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.

Synonyms & Abbreviations: (see Synonym Details)
Acute lymphatic leukaemia
acute lymphatic leukemia
Acute lymphoblastic leukaemia [ALL]
Acute lymphoblastic leukaemia, precursor-cell type
Acute lymphoblastic leukaemia-lymphoma
Acute lymphoblastic leukaemia
Acute lymphoblastic leukemia [ALL]
Acute lymphoblastic leukemia NOS
Acute lymphoblastic leukemia, NOS
Acute lymphoblastic leukemia, precursor-cell type
Acute lymphoblastic leukemia-lymphoma, NOS
Acute lymphoblastic leukemia-lymphoma
acute lymphoblastic leukemia
Acute Lymphocytic Leukaemia
Acute Lymphocytic Leukemias
ACUTE LYMPHOCYTIC LEUKEMIA
Acute Lymphogenous Leukemia
Acute lymphoid leukaemia, disease
Acute lymphoid leukaemia
Acute lymphoid leukemia, disease (disorder)
Acute lymphoid leukemia, disease
Acute Lymphoid Leukemia
ALL - Acute lymphoblastic leukaemia
ALL - Acute lymphoblastic leukemia
ALL - Acute Lymphocytic Leukemia
ALL1
ALL
Leukaemia lymphoblastic acute
Leukaemias acute lymphocytic
LEUKEMIA ACUTE LYMPHOBLASTIC
LEUKEMIA LYMPHOBLASTIC ACUTE
Leukemia, Acute Lymphoblastic
Leukemia, Acute Lymphocytic
Leukemia, Acute Lymphoid
LEUKEMIA, LYMPHOBLASTIC, ACUTE
LEUKEMIA, LYMPHOBLASTIC, MALIGNANT
Leukemia, Lymphoblastic
LEUKEMIA, LYMPHOCYTIC, ACUTE
Leukemia, Lymphoid, Acute
Leukemias acute lymphocytic
Lymphoblastic leukaemia
Lymphoblastic Leukemia, Acute
Lymphoblastic leukemia, NOS
Lymphoblastic Leukemia
Lymphoblastic Lymphoma
Lymphocytic Leukemia, Acute
Lymphoid leukaemia, acute
Lymphoid leukemia, acute
Lymphoma, Lymphoblastic
Precursor cell lymphoblastic leukaemia, not phenotyped
Precursor cell lymphoblastic leukaemia
Precursor cell lymphoblastic leukemia (morphologic abnormality)
Precursor Cell Lymphoblastic Leukemia Lymphoma
Precursor cell lymphoblastic leukemia, NOS
Precursor cell lymphoblastic leukemia, not phenotyped
Precursor Cell Lymphoblastic Leukemia-Lymphoma [Disease/Finding]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Precursor Cell Lymphoblastic Leukemia
Precursor Lymphoblasic Leukemia
Precursor Lymphoblastic Leukemia

External Source Codes: 
NCI Thesaurus Code C3167 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Contributing_Source CDISC NCI
Contributing_Source CTEP NCI
Contributing_Source CTRP NCI
Contributing_Source MedDRA NCI
Contributing_Source NICHD NCI
CTV3ID B640. SNOMEDCT_US
CTV3ID XU7H1 SNOMEDCT_US
DATE_CREATED 03/15/2001 MEDLINEPLUS
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2004-1620 CSP
DISEASE_IDENTIFIER_ID 6739 GARD
DISEASE_IDENTIFIER_ID 6740 GARD
DX 20080101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20050131 SNOMEDCT_US
GENELOCUS ,8,q,2,1, OMIM
GENESYMBOL NBN OMIM
GENESYMBOL NBS1 OMIM
HAS_GARD_PAGE true GARD
HN 2008; for LYMPHOBLASTIC LEUKEMIA use LEUKEMIA, LYMPHOID 1989-2007 MSH
IAN DEFAULT ICD10
ICD-O-3_Code 9835/3 NCI
ICD-O-3_CODE 9835/3 SNOMEDCT_US
IDENTIFIER_TYPE_ID 1 GARD
IS_ACTIVE true GARD
IS_RARE true GARD
IS_SPANISH false GARD
MDA 20070709 MSH
MESH_DEFINITION A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias. NDFRT
MESH_DUI D054198 NDFRT
MESH_NAME Precursor Cell Lymphoblastic Leukemia-Lymphoma NDFRT
MESH_UI M0502706 NDFRT
MIMTYPE 5 OMIM
MIMTYPEMEANING Mendelian phenotype or locus, molecular basis unknown. OMIM
MIMTYPEVALUE perc OMIM
MMR 20120703 MSH
MN C04.557.337.428.600 MSH
MN C15.604.515.560.600 MSH
MN C20.683.515.528.600 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/acutelymphocyticleukemia.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/acutelymphocyticleukemia.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Cancer Institute http://www.nci.nih.gov/ MEDLINEPLUS
NCI_THESAURUS_CODE C3167 PDQ
NDFRT_KIND DISEASE_KIND NDFRT
Neoplastic_Status Malignant NCI
NICHD_Hierarchy_Term Acute Lymphoblastic Leukemia NCI
NUI N0000181267 NDFRT
ORDER_NO 02585 ICD10CM
ORIG_STY Neoplasm diagnosis PDQ
PID 816 PDQ
PM 2008; for LYMPHOBLASTIC LEUKEMIA see LEUKEMIA, LYMPHOCYTIC 1989-2007; for LEUKEMIA, LYMPHOCYTIC, ACUTE see LEUKEMIA, LYMPHOCYTIC ACUTE 1989-2007 MSH
PRIMARY_PATH 10000846$10024290$10024324$10029104$Acute lymphocytic leukaemia$Leukaemias acute lymphocytic$Leukaemias$Neoplasms benign, malignant and unspecified (incl cysts and polyps) MDR
PRIMARY_SOC 10029104 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/522/acute-lymphoblastic-leukemia/resources/1 GARD
RXAUI 3286633 RXNORM
RXAUI 3287771 RXNORM
RXAUI 3287772 RXNORM
RXAUI 3287778 RXNORM
RXAUI 3287788 RXNORM
RXAUI 3287894 RXNORM
RXAUI 3287895 RXNORM
RXAUI 3287899 RXNORM
RXAUI 3287900 RXNORM
RXAUI 3287923 RXNORM
RXAUI 3288442 RXNORM
RXAUI 3288443 RXNORM
RXAUI 5039572 RXNORM
RXCUI 1024792 RXNORM
SEE_ALSO (see also M-9727/3) ICDO
SID HP:0004803 HPO
SID HP:0005555 HPO
SMQ_TERM_ADDVERSION 10.0 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 20.0 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMEDID DC-F4423 SNOMEDCT_US
SNOMEDID M-98353 SNOMEDCT_US
SOS Excludes: acute exacerbation of chronic lymphoid leukemia (204.1) ICD9CM
SUBSET_MEMBER 446608001~MAPTARGET~9835/3 SNOMEDCT_US
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS C91.0 | POSSIBLE REQUIREMENT FOR MORPHOLOGY CODE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~C91.0 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS C91.00 | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~C91.00 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~B640. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XU7H1 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~DC-F4423 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~M-98353 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERM_LEVEL 4 ICDO
TERM_LEVEL Synonym ICDO
TERMUI T023661 MSH
TERMUI T023662 MSH
TERMUI T045612 MSH
TERMUI T045613 MSH
TERMUI T045614 MSH
TERMUI T045615 MSH
TERMUI T049026 MSH
TERMUI T049027 MSH
TERMUI T683424 MSH
TERMUI T690095 MSH
TERMUI T690096 MSH
TERMUI T812685 MSH
TH NLM (1989) MSH
TH NLM (1991) MSH
TH NLM (2008) MSH
TH OMIM (2013) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0023449

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