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Terms & Properties

Concept Unique Identifier (CUI): C0023418

NCI Thesaurus Code: C3161  (see NCI Thesaurus info)

Semantic Type: Neoplastic Process

NCIt Definition: A malignant (clonal) hematologic disorder, involving hematopoietic stem cells and characterized by the presence of primitive or atypical myeloid or lymphoid cells in the bone marrow and the blood. Leukemias are classified as acute or chronic based on the degree of cellular differentiation and the predominant cell type present. Leukemia is usually associated with anemia, fever, hemorrhagic episodes, and splenomegaly. Common leukemias include acute myeloid leukemia, chronic myelogenous leukemia, acute lymphoblastic or precursor lymphoblastic leukemia, and chronic lymphocytic leukemia. Treatment is vital to patient survival; untreated, the natural course of acute leukemias is normally measured in weeks or months, while that of chronic leukemias is more often measured in months or years.

RADLEX Definition: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. It is classified according to degree of cell differentiation as acute or chronic, and according to predominant type of cell involved as myelogenous or lymphocytic. (Dorland, 28th ed) [MeSH]

PDQ Definition: A malignant (clonal) hematologic disorder, involving hematopoietic stem cells and characterized by the presence of primitive or atypical myeloid or lymphoid cells in the bone marrow and the blood. Leukemias are classified as acute or chronic based on the degree of cellular differentiation and the predominant cell type present. Leukemia is usually associated with anemia, fever, hemorrhagic episodes, and splenomegaly. Common leukemias include acute myeloid leukemia, chronic myelogenous leukemia, acute lymphoblastic or precursor lymphoblastic leukemia, and chronic lymphocytic leukemia. Treatment is vital to patient survival; untreated, the natural course of acute leukemias is normally measured in weeks or months, while that of chronic leukemias is more often measured in months or years. Check for active clinical trials using this agent. (NCI Thesaurus)

HPO Definition: A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes. [HPO:probinson]

MEDLINEPLUS Definition: 

Leukemia is cancer of the white blood cells. White blood cells help your body fight infection. Your blood cells form in your bone marrow. In leukemia, the bone marrow produces abnormal white blood cells. These cells crowd out the healthy blood cells, making it hard for blood to do its work.

There are different types of leukemia, including

Leukemia can develop quickly or slowly. Chronic leukemia grows slowly. In acute leukemia, the cells are very abnormal and their number increases rapidly. Adults can get either type; children with leukemia most often have an acute type. Some leukemias can often be cured. Other types are hard to cure, but you can often control them. Treatments may include chemotherapy, radiation and stem cell transplantation. Even if symptoms disappear, you might need therapy to prevent a relapse.

NIH: National Cancer Institute

NICHD Definition: A cancer of the blood or bone marrow that is characterized by increased production of abnormal blood cells.

CDISC Definition: A progressive, proliferative disease of blood cells, originating from myeloid or lymphoid stem cells.

NCI-GLOSS Definition: Cancer that starts in blood-forming tissue such as the bone marrow and causes large numbers of blood cells to be produced and enter the bloodstream.

CTEP Definition: CTEP_For_FDA: 10024312/Leukemia NOS

CSP Definition: progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow; classified according to degree of cell differentiation as acute or chronic, and according to predominant type of cell involved as myelogenous or lymphocytic.

MSH Definition: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)

Synonyms & Abbreviations: (see Synonym Details)
-- Leukemia
Aleukaemic leukaemia [obs]
Aleukemic leukemia [obs]
Blood (Leukemia)
Chronic leukaemia [obs]
Chronic leukemia [obs]
Leucocythaemias
Leucocythaemia
Leucocythemias
Leucocythemia
Leukämie
Leukaemia morphology
Leukaemia NOS
Leukaemia of unspecified cell type
Leukaemia unspecified
Leukaemia, disease
Leukaemia, no ICD-O subtype
Leukaemia, unspecified
Leukaemias
LEUKAEMIA
Leukemia [Disease/Finding]
Leukemia morphology
Leukemia NOS
Leukemia of unspecified cell type (C95)
Leukemia of unspecified cell type
Leukemia unspecified
Leukemia, disease (disorder)
Leukemia, Disease
LEUKEMIA, MALIGNANT
Leukemia, no ICD-O subtype
Leukemia, no International Classification of Diseases for Oncology subtype (morphologic abnormality)
Leukemia, no International Classification of Diseases for Oncology subtype
Leukemia, NOS
Leukemia, unspecified
Leukemias, General
Leukemias, NOS
Leukemias
leukemia
Subacute leukaemia [obs]
Subacute leukemia [obs]
Unspecified leukaemia without mention of remission
Unspecified leukaemia
Unspecified leukemia without mention of remission
Unspecified leukemia

External Source Codes: 
NCI Thesaurus Code C3161 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN general or unspecified; many specific leukemia types are available MSH
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Contributing_Source CDISC NCI
Contributing_Source CTEP NCI
Contributing_Source CTRP NCI
Contributing_Source MedDRA NCI
Contributing_Source NICHD NCI
CTV3ID BBr.. SNOMEDCT_US
CTV3ID XUNuu SNOMEDCT_US
DATE_CREATED 10/12/2010 MEDLINEPLUS
DATE_LAST_MODIFIED 2012-03-26 PDQ
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2004-1566 CSP
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EXCLUDES1 personal history of leukemia (Z85.6) ICD10CM
EXTERNALLY_DEFINED N LNC
FX D017254 MSH
IAN DEFAULT ICD10
ICD-O-3_Code 9800/3 NCI
ICD-O-3_CODE 9800/3 SNOMEDCT_US
ICE Leukemia NOS ICD9CM
ICF The following fifth-digit subclassification is for use with category 208: {0 without mention of having achieved remission, failed remission; 1 in remission; 2 in relapse} ICD9CM
IPX -C91 ICPC
IPX -C92 ICPC
IPX -C93 ICPC
IPX -C94 ICPC
IPX -C95 ICPC
MDA 19990101 MSH
MESH_DEFINITION A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006) NDFRT
MESH_DUI D007938 NDFRT
MESH_NAME Leukemia NDFRT
MESH_UI M0012382 NDFRT
MMR 20110624 MSH
MN C04.557.337 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/leukemia.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Chinese - Simplified https://www.nlm.nih.gov/medlineplus/languages/leukemia.html#Chinese - Simplified MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Chinese - Traditional https://www.nlm.nih.gov/medlineplus/languages/leukemia.html#Chinese - Traditional MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/leukemia.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Cancer Institute http://www.nci.nih.gov/ MEDLINEPLUS
NCI_THESAURUS_CODE C3161 PDQ
NDFRT_KIND DISEASE_KIND NDFRT
Neoplastic_Status Malignant NCI
NICHD_Hierarchy_Term Leukemia NCI
NUI N0000001815 NDFRT
ORDER_NO 02705 ICD10CM
ORDER_NO 02714 ICD10CM
ORIG_STY Neoplasm diagnosis PDQ
PID 426 PDQ
PRIMARY_PATH 10024288$10024310$10024324$10029104$Leukaemia$Leukaemias NEC$Leukaemias$Neoplasms benign, malignant and unspecified (incl cysts and polyps) MDR
PRIMARY_SOC 10029104 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RXAUI 3188778 RXNORM
RXAUI 3188804 RXNORM
RXAUI 4223311 RXNORM
RXAUI 4223312 RXNORM
RXCUI 1021987 RXNORM
SID HP:0005519 HPO
SID HP:0006726 HPO
SMQ_TERM_ADDVERSION 10.0 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 20.0 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 188762002 NDFRT
SNOMED_CID 93143009 NDFRT
SUBSET_MEMBER 446608001~MAPTARGET~9800/3 SNOMEDCT_US
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS C95.9 | POSSIBLE REQUIREMENT FOR MORPHOLOGY CODE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~C95.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS C95.90 | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~C95.90 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~BBr.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUNuu SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERM_LEVEL 2 ICDO
TERM_LEVEL 3 ICDO
TERM_LEVEL 4 ICDO
TERMUI T023645 MSH
TERMUI T786153 MSH
TERMUI T786154 MSH
TH NLM (1978) MSH
TH NLM (2012) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

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