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Leucine (CUI C0023401) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0023401

NCI Thesaurus Code: C29599  (see NCI Thesaurus info)

Semantic Type: Biologically Active Substance

Semantic Type: Amino Acid, Peptide, or Protein

Semantic Type: Pharmacologic Substance

NCIt Definition: One of nine essential amino acids in humans (provided by food), Leucine is important for protein synthesis and many metabolic functions. Leucine contributes to regulation of blood-sugar levels; growth and repair of muscle and bone tissue; growth hormone production; and wound healing. Leucine also prevents breakdown of muscle proteins after trauma or severe stress and may be beneficial for individuals with phenylketonuria. Leucine is available in many foods and deficiency is rare. (NCI04)

CRCH Definition: Amino acid with side chain -CH2CH(CH3)2.

CSP Definition: essential branched-chain amino acid important for hemoglobin formation.

MSH Definition: An essential branched-chain amino acid important for hemoglobin formation.

NPO Definition: An alpha-aminoacid with chemical formula NH2-CH(CH2-CH(CH3)-CH3)-C(OH)=OH.

Synonyms & Abbreviations: (see Synonym Details)
(2S)-2-Amino-4-methylpentanoic acid
(2S)-alpha-2-Amino-4-methylvaleric acid
(2S)-alpha-Leucine
(S)-(+)-Leucine
(S)-2-Amino-4-methylpentanoic acid
(S)-Leucine
2-amino-4-methylpentanoic acid
2-Amino-4-methylvaleric acid
L-Isomer Leucine
L-Leucine (product)
L-Leucine
L-Leucin
L-Leuzin
Leucine (product)
Leucine (substance)
Leucine [Chemical/Ingredient]
Leucine, L Isomer
Leucine, L-Isomer
leucine
Leu
L

External Source Codes: 
NCI Thesaurus Code C29599 (see NCI Thesaurus info)
CAS Registry Number 61-90-5 (see NLM ChemIDplus info)
FDA UNII Code GMW67QNF9C
NSC Code 9252 (see NCI DTP info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN /biosyn /defic /physiol permitted MSH
AQL AA AD AE AG AI AN BI BL CF CH CL CS CT DE DF EC GE HI IM IP ME PD PH PK PO RE SD SE ST TO TU UR MSH
AUTHORITY Rosse MD FMA
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:15603 NCI
Chemical_Formula C6H13NO2 NCI
CODE NPO_285 NPO
Contributing_Source CRCH NCI
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID X807P SNOMEDCT_US
CTV3ID XUc1M SNOMEDCT_US
CTV3ID XUc1N SNOMEDCT_US
DB_XR_ID CHEBI:25017 NPO
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0124-2988 CSP
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20040731 SNOMEDCT_US
Essential_Amino_Acid Y NCI
FDA_UNII_CODE GMW67QNF9C DRUGBANK
FDA_UNII_CODE GMW67QNF9C NDFRT
INFOODS LEU_G NCI
LEVEL Ingredient NDFRT
Macronutrient Y NCI
MDA 19990101 MSH
MESH_DEFINITION An essential branched-chain amino acid important for hemoglobin formation. NDFRT
MESH_DUI D007930 NDFRT
MESH_NAME Leucine NDFRT
MESH_UI M0012372 NDFRT
MMR 20130708 MSH
MN D12.125.070.637 MSH
MN D12.125.142.441 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006558 NDFRT
NUI N0000146995 NDFRT
Nutrient Y NCI
RDF_ID CHEBI_25017 NPO
RN GMW67QNF9C MSH
RR 61-90-5 (Leucine) MSH
RR 7005-03-0 MSH
RXAUI 200481 RXNORM
RXAUI 2072038 RXNORM
RXAUI 2597317 RXNORM
RXAUI 3053930 RXNORM
RXAUI 3185278 RXNORM
RXAUI 3186113 RXNORM
RXAUI 3186114 RXNORM
RXAUI 3188733 RXNORM
RXAUI 3188746 RXNORM
RXAUI 3188751 RXNORM
RXAUI 6798213 RXNORM
RXCUI 6308 RXNORM
SID NUTR00033 DRUGBANK
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SPL_SET_ID ef345c23-20a8-40d4-bf3c-5650ed81e2f1 MTHSPL
SPL_SET_ID f0779c98-8eca-4256-a27d-0136395846ba MTHSPL
SPL_SET_ID f0c53be7-01ac-40ed-b3cd-8911ba704346 MTHSPL
SPL_SET_ID f3c9743b-9c5d-49e9-a7e7-ecb6560ffa84 MTHSPL
SPL_SET_ID f452b457-5ca1-4fdc-a319-eadbc04e953a MTHSPL
SPL_SET_ID f8366a24-06ac-4417-a1fc-ea7338a0781d MTHSPL
SPL_SET_ID f83c73bc-82b9-41d3-be8a-987f8bd28d05 MTHSPL
SPL_SET_ID fd0b42d6-6733-4525-6283-715ee5a466a9 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~X807P SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUc1M SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUc1N SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T023617 MSH
TERMUI T023618 MSH
TERMUI T360395 MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH NLM (1966) MSH
TH NLM (1999) MSH
TH UNK (19XX) MSH
TH USAN (19XX) MSH
TH USP (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
Unit g NCI
USDA_ID 504 NCI
VANDF_RECORD 50.416^1285^Active/Master NDFRT
VUID 4018684 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0023401

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