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Lambert-Eaton Myasthenic Syndrome (CUI C0022972) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0022972

NCI Thesaurus Code: C3155  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: A rare autoimmune presynaptic disorder characterized by impairment of the impulse transmission at the neuromuscular junction. It affects predominantly the proximal muscles of the lower extremities, resulting in muscle weakness and fatigability. It has been associated with small cell lung carcinoma.

GARD Definition: Lambert Eaton myasthenic syndrome (LEMS) is a disorder of the neuromuscular junction. The neuromuscular junction is the site where nerve cells meet muscle cells and help activate the muscles. This syndrome occurs when antibodies interfere with electrical impulses between the nerve and muscle cells. It may be associated with other autoimmune diseases, or more commonly coincide with or precede a diagnosis of cancer such as small cell lung cancer. Symptoms may include muscle weakness, a tingling sensation in the affected areas, fatigue, and dry mouth. Treatment of a underlying disorder or cancer is the first priority of treatment. - this information is from GARD/ORDR/NCATS.

MSH Definition: An autoimmune disease characterized by weakness and fatigability of proximal muscles, particularly of the pelvic girdle, lower extremities, trunk, and shoulder girdle. There is relative sparing of extraocular and bulbar muscles. CARCINOMA, SMALL CELL of the lung is a frequently associated condition, although other malignancies and autoimmune diseases may be associated. Muscular weakness results from impaired impulse transmission at the NEUROMUSCULAR JUNCTION. Presynaptic calcium channel dysfunction leads to a reduced amount of acetylcholine being released in response to stimulation of the nerve. (From Adams et al., Principles of Neurology, 6th ed, pp 1471)

Synonyms & Abbreviations: (see Synonym Details)
Eaton Lambert Myasthenic Syndrome
Eaton Lambert syndrome
Eaton-Lambert Myasthenic Syndrome
Eaton-Lambert Myasthenic-Myopathic Syndrome
Eaton-Lambert Myopathic-Myasthenic Syndromes
Eaton-Lambert Myopathic-Myasthenic Syndrome
Eaton-Lambert syndrome (disorder)
EATON-LAMBERT SYNDROME
EATON-LAMBERT-ROOKE SYNDROME
Lambert Eaton myasthenic syndrome
Lambert Eaton syndrome
Lambert-Eaton Myasthenic Syndrome [Disease/Finding]
Lambert-Eaton myasthenic syndrome
Lambert-Eaton Myasthenic-Myopathic Syndromes
Lambert-Eaton Myasthenic-Myopathic Syndrome
Lambert-Eaton Myopathic-Myasthenic Syndromes
Lambert-Eaton Myopathic-Myasthenic Syndrome
Lambert-Eaton syndrome NOS
Lambert-Eaton syndrome
LEMS - Lambert-Eaton myasthenic syndrome
LEMS
MYASTHENIC MYOPATHIC SYNDROME LAMBERT EATON
Myasthenic Myopathic Syndrome of Eaton Lambert
Myasthenic Myopathic Syndrome of Lambert Eaton
myasthenic syndrome of Lambert Eaton
Myasthenic syndrome of Lambert-Eaton
Myasthenic Syndrome, Eaton-Lambert
Myasthenic Syndrome, Lambert Eaton
Myasthenic Syndrome, Lambert-Eaton
Myasthenic syndrome
Myasthenic-Myopathic Syndrome of Eaton-Lambert
Myasthenic-Myopathic syndrome of Lambert-Eaton
Myopathic Myasthenic Syndrome of Eaton Lambert
MYOPATHIC MYASTHENIC SYNDROME OF LAMBERT EATON
Myopathic-Myasthenic Syndrome of Eaton-Lambert
Myopathic-Myasthenic Syndrome of Lambert-Eaton
Syndrome, Eaton-Lambert Myasthenic
Syndrome, Eaton-Lambert
Syndrome, Lambert-Eaton Myasthenic
Syndrome, Lambert-Eaton

External Source Codes: 
NCI Thesaurus Code C3155 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
Contributing_Source CTRP NCI
CTV3ID F3810 SNOMEDCT_US
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_CREATED 2015-01-22T00:04:00 GARD
DATE_FIRST_PUBLISHED 2009-01-29 PDQ
DATE_LAST_MODIFIED 2010-01-29 PDQ
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0944-7801 CSP
DID 2017-5738 CSP
DID 2057-3596 CSP
DISEASE_IDENTIFIER_ID 33093 GARD
DISEASE_IDENTIFIER_ID 4340 GARD
DISEASE_IDENTIFIER_ID 4341 GARD
DISEASE_IDENTIFIER_ID 4342 GARD
DISEASE_IDENTIFIER_ID 4343 GARD
DISEASE_IDENTIFIER_ID 4344 GARD
DX 19900101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
HAS_GARD_PAGE true GARD
HN 1990 MSH
IAN ASTERISK ICD10
ICE Eaton-Lambert syndrome ICD9CM
IDENTIFIER_SOURCE Orp GARD
IDENTIFIER_TYPE_ID 1 GARD
IS_ACTIVE true GARD
IS_RARE true GARD
IS_SPANISH false GARD
LAST_REVIEW_DATE 2009-10-09T00:00:00 GARD
MDA 19890407 MSH
MESH_DEFINITION An autoimmune disease characterized by weakness and fatigability of proximal muscles, particularly of the pelvic girdle, lower extremities, trunk, and shoulder girdle. There is relative sparing of extraocular and bulbar muscles. CARCINOMA, SMALL CELL of the lung is a frequently associated condition, although other malignancies and autoimmune diseases may be associated. Muscular weakness results from impaired impulse transmission at the NEUROMUSCULAR JUNCTION. Presynaptic calcium channel dysfunction leads to a reduced amount of acetylcholine being released in response to stimulation of the nerve. (From Adams et al., Principles of Neurology, 6th ed, pp 1471) NDFRT
MESH_DUI D015624 NDFRT
MESH_NAME Lambert-Eaton Myasthenic Syndrome NDFRT
MESH_UI M0023968 NDFRT
MMR 20150622 MSH
MN C04.588.614.550.225 MSH
MN C04.730.856.225 MSH
MN C10.114.468 MSH
MN C10.574.781.500 MSH
MN C10.668.758.450 MSH
MN C20.111.258.350 MSH
NCI_THESAURUS_CODE C3155 PDQ
NDFRT_KIND DISEASE_KIND NDFRT
NUI N0000003300 NDFRT
ORIG_STY Secondary related condition PDQ
PM 1990 MSH
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/6851/lambert-eaton-myasthenic-syndrome/resources/1 GARD
RXAUI 3153034 RXNORM
RXAUI 3153038 RXNORM
RXAUI 3188096 RXNORM
RXAUI 3188097 RXNORM
RXAUI 3188102 RXNORM
RXAUI 3200506 RXNORM
RXAUI 3200510 RXNORM
RXAUI 3200511 RXNORM
RXAUI 3200940 RXNORM
RXAUI 3200941 RXNORM
RXCUI 988889 RXNORM
SMQ_TERM_ADDVERSION 10.0 MDR
SMQ_TERM_ADDVERSION 10.1 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 10.1 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 56989000 NDFRT
SNOMEDID DA-50130 SNOMEDCT_US
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS G70.8 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~G70.8 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS G73.1 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF EATON LAMBERT SYNDROME WITH UNDERLYING MALIGNANCY CHOOSE C80.1 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF EATON LAMBERT SYNDROME WITH UNDERLYING MALIGNANCY CHOOSE G73.1 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF EATON LAMBERT SYNDROME WITHOUT UNDERLYING MALIGNANCY CHOOSE G70.80 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~MAP SOURCE CONCEPT CANNOT BE CLASSIFIED WITH AVAILABLE DATA SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447638001 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447639009 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 292991000119106 | Eaton Lambert syndrome without underlying malignancy (disorder) | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 608874000 | Eaton Lambert syndrome with underlying malignancy (disorder) | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~OTHERWISE TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~C80.1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~G70.80 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~G73.1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~ SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~F3810 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~DA-50130 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T046211 MSH
TERMUI T046212 MSH
TERMUI T046213 MSH
TERMUI T046214 MSH
TERMUI T046215 MSH
TERMUI T368374 MSH
TERMUI T368375 MSH
TERMUI T368376 MSH
TERMUI T368377 MSH
TH NLM (1990) MSH
TH NLM (1999) MSH
TH NLM (2000) MSH
TH ORD (2010) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

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