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Lactose Intolerance (CUI C0022951) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0022951

NCI Thesaurus Code: C3154  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: Inability to fully digest and absorb lactose due to limited or no lactase activity in the small intestine. Congenital intolerance is inherited following an autosomal recessive pattern but is rare. It is more often due to a gradual decline of lactase production in adulthood following the ingestion of fewer lactose-containing foods or secondary to an intestinal mucosal brush-border injury. Prevalence is highest among Asians, Native Americans and Africans. Clinical signs include abdominal cramping, bloating, flatulence and diarrhea following the dietary intake of lactose.

MEDLINEPLUS Definition: 

Lactose intolerance means that you cannot digest foods with lactose in them. Lactose is the sugar found in milk and foods made with milk. After eating foods with lactose in them, you may feel sick to your stomach. You may also have

  • Gas
  • Diarrhea
  • Swelling in your stomach

Your doctor may do a blood, breath or stool test to find out if your problems are due to lactose intolerance.

Lactose intolerance is not serious. Eating less food with lactose, or using pills or drops to help you digest lactose usually helps. You may need to take a calcium supplement if you don't get enough of it from your diet, since milk and foods made with milk are the most common source of calcium for most people.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases

HPO Definition: An inability to digest lactose. [HPO:probinson]

NCI-GLOSS Definition: The inability to digest or absorb lactose, a type of sugar found in milk and other dairy products.

MSH Definition: The condition resulting from the absence or deficiency of LACTASE in the MUCOSA cells of the GASTROINTESTINAL TRACT, and the inability to break down LACTOSE in milk for ABSORPTION. Bacterial fermentation of the unabsorbed lactose leads to symptoms that range from a mild indigestion (DYSPEPSIA) to severe DIARRHEA. Lactose intolerance may be an inborn error or acquired.

Synonyms & Abbreviations: (see Synonym Details)
Alactasia
Cow's milk enteropathy
Dairy product intolerance
Hypolactasia
Intolerance or malabsorption of lactose
Intolerance, Lactose
Lactose intolerance (disorder)
Lactose Intolerance [Disease/Finding]
Lactose intolerance, unspecified
LACTOSE INTOLERANCE
Lactose Malabsorption
LM - Lactose malabsorption
Malabsorption, Lactose
Milk intolerance (disorder)
MILK INTOLERANCE
MILK SUGAR INTOLERANCE

External Source Codes: 
NCI Thesaurus Code C3154 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL BL CF CI CL CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CTV3ID XE11K SNOMEDCT_US
CTV3ID XUmrF SNOMEDCT_US
DATE_CREATED 11/23/1999 MEDLINEPLUS
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0551-8201 CSP
DX 19670101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20150131 SNOMEDCT_US
HN 67(64) MSH
IAN DEFAULT ICD10
MDA 19990101 MSH
MESH_DEFINITION The condition resulting from the absence or deficiency of LACTASE in the MUCOSA cells of the GASTROINTESTINAL TRACT, and the inability to break down LACTOSE in milk for ABSORPTION. Bacterial fermentation of the unabsorbed lactose leads to symptoms that range from a mild indigestion (DYSPEPSIA) to severe DIARRHEA. Lactose intolerance may be an inborn error or acquired. NDFRT
MESH_DUI D007787 NDFRT
MESH_NAME Lactose Intolerance NDFRT
MESH_UI M0012180 NDFRT
MMR 20130708 MSH
MN C06.405.469.637.506 MSH
MN C16.320.565.202.589 MSH
MN C18.452.603.506 MSH
MN C18.452.648.202.589 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
MODULE_ID 731000124108 SNOMEDCT_US
MODULE_NAME US National Library of Medicine maintained module SNOMEDCT_US
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/lactoseintolerance.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/lactoseintolerance.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Institute of Diabetes and Digestive and Kidney Diseases http://www.niddk.nih.gov/ MEDLINEPLUS
NDFRT_KIND DISEASE_KIND NDFRT
NUI N0000001777 NDFRT
ORDER_NO 04599 ICD10CM
ORDER_NO 04603 ICD10CM
PM 67 MSH
PRIMARY_PATH 10023681$10042454$10016950$10027433$Lactose intolerance$Sugar intolerance (excl glucose intolerance)$Food intolerance syndromes$Metabolism and nutrition disorders MDR
PRIMARY_SOC 10027433 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
REF orcid.org/0000-0001-6908-9849 HPO
RXAUI 3188060 RXNORM
RXAUI 3188061 RXNORM
RXAUI 3188062 RXNORM
RXAUI 5930154 RXNORM
RXAUI 5930685 RXNORM
RXAUI 5931179 RXNORM
RXAUI 5931615 RXNORM
RXCUI 1025110 RXNORM
SNOMED_CID 267425008 NDFRT
SNOMEDID D5-40060 SNOMEDCT_US
SNOMEDID R-FB652 SNOMEDCT_US
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS E73.9 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS K90.4 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~E73.9 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~K90.4 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS E73.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS K90.49 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF ACQUIRED LACTASE DEFICIENCY CHOOSE E73.1 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF CONGENITAL LACTASE DEFICIENCY CHOOSE E73.0 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF HEREDITARY GASTROGENIC LACTOSE INTOLERANCE CHOOSE E73.8 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF LACTASE DEFICIENCY IN DISEASES OTHER THAN OF THE SMALL INTESTINE CHOOSE E73.8 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF LACTOSE INTOLERANCE IN CHILDREN WITHOUT LACTASE DEFICIENCY CHOOSE E73.8 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF NONPERSISTENCE OF INTESTINAL LACTASE CHOOSE E73.8 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF PRIMARY LACTOSE INTOLERANCE CHOOSE E73.8 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447639009 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~4 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~5 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~6 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~7 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~8 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 190751001 | Primary lactose intolerance (disorder) | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 25744000 | Hereditary gastrogenic lactose intolerance (disorder) | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 29512005 | Lactase deficiency in diseases other than of the small intestine (disorder) | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 38032004 | Nonpersistence of intestinal lactase (disorder) | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 5388008 | Congenital lactase deficiency (disorder) | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 54250004 | Lactose intolerance in children without lactase deficiency (disorder) | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 60414003 | Acquired lactase deficiency (disorder) | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~OTHERWISE TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~E73.0 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~E73.1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~E73.8 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~E73.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~K90.49 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XE11K SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUmrF SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~D5-40060 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~R-FB652 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T023308 MSH
TERMUI T023309 MSH
TERMUI T841854 MSH
TERMUI T841855 MSH
TERMUI T841856 MSH
TERMUI T841857 MSH
TH GHR (2014) MSH
TH NLM (1964) MSH
TH NLM (1998) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0022951

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