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Isoflurane (CUI C0022180) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0022180

NCI Thesaurus Code: C65978  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Pharmacologic Substance

NCIt Definition: A fluorinated ether with general anesthetic and muscle relaxant activities. Although the exact mechanism of action has not been established, inhaled isoflurane, appears to act on the lipid matrix of the neuronal cell membrane, which results in disruption of neuronal transmission. This agent enhances the release of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), thereby increasing the activity of the inhibitory neurotransmitter on synaptic transmission. Isoflurane may also both inhibit glutamatergic excitatory transmission by increasing glutamate re-uptake, and potentiate glycine receptor activity, which decreases motor function. In addition, isoflurane may alter certain pro- and anti-inflammatory cytokines, including interleukin-6 and -10 (IL-6, IL-10), possibly through the activation of the nuclear factor kappa B (NF-KB) pathway, which may affect immune responses during surgery.

PDQ Definition: A fluorinated ether with general anesthetic and muscle relaxant activities. Although the exact mechanism of action has not been established, inhaled isoflurane, appears to act on the lipid matrix of the neuronal cell membrane, which results in disruption of neuronal transmission. This agent enhances the release of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), thereby increasing the activity of the inhibitory neurotransmitter on synaptic transmission. Isoflurane may inhibit glutamatergic excitatory transmission by increasing glutamate re-uptake and it may potentiate glycine receptor activity, which decreases motor function. In addition, isoflurane may alter certain pro- and anti-inflammatory cytokines, including interleukin-6 and -10 (IL-6, IL-10), possibly through the activation of the nuclear factor kappa B (NF-KB) pathway, which may affect immune responses during surgery. Check for active clinical trials using this agent. (NCI Thesaurus)

CSP Definition: F2CHOCHCl-CF3; used as an inhalation anesthetic; may act via beta adrenergic or muscarinic receptors; adverse side effects are hypotension and risk of myocardial ischemia and cardiac arrest.

MSH Definition: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.

Synonyms & Abbreviations: (see Synonym Details)
1-chloro-2,2,2-trifluoroethyl difluoromethyl ether (SN); 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane
1-chloro-2,2,2-Trifluoroethyl difluoromethyl ether
2-Chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane
26675-46-7
Aerrane
Ethane, 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro-
Forane
Isoflo
Isoflurane (substance)
Isoflurane [Chemical/Ingredient]
isoflurane
Isoflurano
Isofluranum
Product containing isoflurane (medicinal product)
Product containing isoflurane

External Source Codes: 
NCI Thesaurus Code C65978 (see NCI Thesaurus info)
CAS Registry Number 26675-46-7 (see NLM ChemIDplus info)
FDA UNII Code CYS9AKD70P
PDQ Closed Trial Search ID 752236
PDQ Open Trial Search ID 752236 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:6015 NCI
Chemical_Formula C3H2ClF5O NCI
Contributing_Source FDA NCI
CTV3ID o25.. SNOMEDCT_US
CTV3ID XUWvE SNOMEDCT_US
DATE_FIRST_PUBLISHED 2013-09-05 PDQ
DATE_LAST_MODIFIED 2013-09-05 PDQ
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 1372-8195 CSP
DX 19870101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20030131 SNOMEDCT_US
FDA_UNII_CODE CYS9AKD70P DRUGBANK
FDA_UNII_CODE CYS9AKD70P NDFRT
HN 87(75); was see under METHYL ETHERS 1975-86 MSH
LEVEL Ingredient NDFRT
LT TRD MTH
LT TRD PDQ
MDA 19741111 MSH
MESH_DEFINITION A stable, non-explosive inhalation anesthetic, relatively free from significant side effects. NDFRT
MESH_DUI D007530 NDFRT
MESH_NAME Isoflurane NDFRT
MESH_UI M0011763 NDFRT
MMR 20130708 MSH
MN D02.355.601.570 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NCI_THESAURUS_CODE C65978 PDQ
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006307 NDFRT
NUI N0000147364 NDFRT
ORIG_STY Drug/agent PDQ
PA D018685 MSH
PM 87; was see under METHYL ETHERS 1975-86 MSH
RN CYS9AKD70P MSH
RR 26675-46-7 (Isoflurane) MSH
RXAUI 191680 RXNORM
RXAUI 2071804 RXNORM
RXAUI 2256635 RXNORM
RXAUI 2714589 RXNORM
RXAUI 2994338 RXNORM
RXAUI 3155764 RXNORM
RXAUI 3177556 RXNORM
RXAUI 3177557 RXNORM
RXAUI 3183230 RXNORM
RXAUI 3183231 RXNORM
RXAUI 5485227 RXNORM
RXCUI 1431961 RXNORM
RXCUI 6026 RXNORM
RXCUI 92754 RXNORM
RXN_BN_CARDINALITY single RXNORM
SID APRD00212 DRUGBANK
SPL_SET_ID 0a83d13c-cd1c-48d9-91fd-215ca310295a MTHSPL
SPL_SET_ID 10e5faa4-2071-4f9f-acd8-a0af1fba9867 MTHSPL
SPL_SET_ID 13c9c37a-0c3d-450a-a61e-d2796818b18f MTHSPL
SPL_SET_ID 1d0315b8-f9c6-412d-8fb9-7dabe5b72eb4 MTHSPL
SPL_SET_ID 208f68ef-3a7b-4547-8f26-bbe504fa72c7 MTHSPL
SPL_SET_ID 3d30eb8d-a62e-475f-926b-78ba63bee9c8 MTHSPL
SPL_SET_ID 3e461f3b-c782-4963-ae93-decb3cd28e91 MTHSPL
SPL_SET_ID 51d92b9b-1226-4bbe-8d42-fb0bfdffabf3 MTHSPL
SPL_SET_ID 59707c98-9803-4070-aca1-15f9635247ae MTHSPL
SPL_SET_ID 85b967e8-a2a8-41f6-8da6-11f4da161ae5 MTHSPL
SPL_SET_ID 8dc7efa4-f28d-45a1-aab5-a5122a1b8449 MTHSPL
SPL_SET_ID 9514c5f9-63d0-45b8-a375-6ae94c74a25a MTHSPL
SPL_SET_ID b0c8964f-24a8-4bab-ae8d-1536737e43ec MTHSPL
SPL_SET_ID b69c2259-d7d8-482d-8443-6279d217da0a MTHSPL
SPL_SET_ID ba95be45-2717-4642-8d37-90036bcbb973 MTHSPL
SPL_SET_ID d6851c71-0c2f-43f6-883c-a43fe894985d MTHSPL
SPL_SET_ID dbeb646f-dc6c-40f2-803c-68858d6ac080 MTHSPL
SPL_SET_ID dfb26527-c5ab-44d0-9236-24b1600e0db4 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~o25.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUWvE SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T022631 MSH
TH BAN (19XX) MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH USAN (1972) MSH
TH USP (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^1713^Active/Master NDFRT
VANDF_RECORD 50.6^1647^Active/Master NDFRT
VUID 4019107 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0022180

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