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Immunohistochemistry (CUI C0021044) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0021044

NCI Thesaurus Code: C23020  (see NCI Thesaurus info)

Semantic Type: Diagnostic Procedure

NCIt Definition: Immunohistochemical staining techniques allow for the visualization of antigens via the sequential application of a specific antibody to the antigen (primary antibody), a secondary antibody to the primary antibody and an enzyme complex with a chromogenic substrate. The enzymatic activation of the chromogen results in a visible reaction product at the antigen site. The specimen may then be counterstained and coverslipped. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen.

NCI-GLOSS Definition: A technique used to identify specific molecules in different kinds of tissue. The tissue is treated with antibodies that bind the specific molecule. These are made visible under a microscope by using a color reaction, a radioisotope, colloidal gold, or a fluorescent dye. Immunohistochemistry is used to help diagnose diseases, such as cancer, and to detect the presence of microorganisms. It is also used in basic research to understand how cells grow and differentiate (become more specialized).

CDISC Definition: Immunohistochemical staining techniques allow for the visualization of antigens via the sequential application of a specific antibody to the antigen (primary antibody), a secondary antibody to the primary antibody and an enzyme complex with a chromogenic substrate. The enzymatic activation of the chromogen results in a visible reaction product at the antigen site. The specimen may then be counterstained and coverslipped. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen.

MSH Definition: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

Synonyms & Abbreviations: (see Synonym Details)
Cell/Tissue, Immunohistochemistry
IHC
Immunohistochemistry procedure (procedure)
Immunohistochemistry procedure
Immunohistochemistry Staining Method
Immunohistochemistry technique (qualifier value)
Immunohistochemistry technique
Immunohistochemistry
IMMUNOHISTOCHEM

External Source Codes: 
NCI Thesaurus Code C23020 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN GEN; avoid as coord; SPEC qualif when IM; no qualif when NIM; immunohistochem of disease is disease /diag or /metab MSH
AQL CL EC ES HI IS MT SN ST TD UT VE MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
Contributing_Source CDISC NCI
Contributing_Source CTRP NCI
CTV3ID XU4PL SNOMEDCT_US
CTV3ID XUqjL SNOMEDCT_US
DATE_LAST_MODIFIED 2007-10-30 PDQ
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 1554-2150 CSP
DX 19880101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20150131 SNOMEDCT_US
HN 88 MSH
MDA 19870508 MSH
MMR 20110624 MSH
MN E01.370.225.500.607.512 MSH
MN E01.370.225.750.551.512 MSH
MN E05.200.500.607.512 MSH
MN E05.200.750.551.512 MSH
MN E05.478.583 MSH
MN H01.158.100.656.234.512 MSH
MN H01.158.201.344.512 MSH
MN H01.158.201.486.512 MSH
MN H01.181.122.573.512 MSH
MN H01.181.122.605.512 MSH
NCI_THESAURUS_CODE C23020 PDQ
ORIG_STY Intervention or procedure PDQ
PID 6567 PDQ
PM 88 MSH
PRIMARY_PATH 10059656$10020126$10022893$10022891$Immunohistochemistry$Histopathology procedures NEC$Investigations, imaging and histopathology procedures NEC$Investigations MDR
PRIMARY_SOC 10022891 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
SUBSET_MEMBER 900000000000497000~MAPTARGET~XU4PL SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUqjL SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T021431 MSH
TH NLM (1988) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0021044

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