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Hypothyroidism (CUI C0020676) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0020676

NCI Thesaurus Code: C26800  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: Abnormally low levels of thyroid hormone.

HPO Definition: Deficiency of thyroid hormone. [HPO:probinson]

MEDLINEPLUS Definition: 

Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. It is one of your endocrine glands, which make hormones. Thyroid hormones control the rate of many activities in your body. These include how fast you burn calories and how fast your heart beats. All of these activities are your body's metabolism. If your thyroid gland is not active enough, it does not make enough thyroid hormone to meet your body's needs. This condition is hypothyroidism.

Hypothyroidism is more common in women, people with other thyroid problems, and those over 60 years old. Hashimoto's disease, an autoimmune disorder, is the most common cause. Other causes include thyroid nodules, thyroiditis, congenital hypothyroidism, surgical removal of part or all of the thyroid, radiation treatment of the thyroid, and some medicines.

The symptoms can vary from person to person. They may include

  • Fatigue
  • Weight gain
  • A puffy face
  • Cold intolerance
  • Joint and muscle pain
  • Constipation
  • Dry skin
  • Dry, thinning hair
  • Decreased sweating
  • Heavy or irregular menstrual periods and fertility problems
  • Depression
  • Slowed heart rate

To diagnose hypothyroidism, your doctor will look at your symptoms and blood tests. Treatment is with synthetic thyroid hormone, taken every day.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases

NCI-GLOSS Definition: Too little thyroid hormone. Symptoms include weight gain, constipation, dry skin, and sensitivity to the cold.

CTCAE Definition: A disorder characterized by a decrease in production of thyroid hormone by the thyroid gland.

NICHD Definition: Reduced secretion of thyroid hormone(s) by the thyroid gland.

CSP Definition: deficiency of thyroid gland activity; characterized by decreased basal metabolic rate, fatigue and lethargy, sensitivity to cold, and menstrual disturbances; untreated it progresses to myxedema; in infants severe hypothyroidism leads to cretinism.

MSH Definition: A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA.

Synonyms & Abbreviations: (see Synonym Details)
Deficiencies, Thyroid-Stimulating Hormone
Deficiencies, TSH
Deficiency, Thyroid-Stimulating Hormone
Deficiency, TSH
Hormone Deficiencies, Thyroid-Stimulating
Hormone Deficiency, Thyroid-Stimulating
Hypothyreosis
Hypothyroidism (disorder)
Hypothyroidism [Disease/Finding]
Hypothyroidism NOS
Hypothyroidism, unspecified
Hypothyroidisms
hypothyroidism
Hypothyroid
Low T4
THYROID ACTIVITY DECREASED
Thyroid Stimulating Hormone Deficiency
Thyroid-Stimulating Hormone Deficiencies
Thyroid-Stimulating Hormone Deficiency
TSH Deficiencies
TSH Deficiency
Underactive thyroid
Unspecified acquired hypothyroidism
Unspecified hypothyroidism

External Source Codes: 
NCI Thesaurus Code C26800 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
ANSWER_CODE 33 LNC
AQL BL CF CI CL CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Contributing_Source CTRP NCI
Contributing_Source MedDRA NCI
Contributing_Source NICHD NCI
CTV3ID XUDWI SNOMEDCT_US
DATE_CREATED 12/23/2013 MEDLINEPLUS
DATE_FIRST_PUBLISHED 2006-06-09 PDQ
DATE_LAST_MODIFIED 2006-06-05 PDQ
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2928-6836 CSP
DX 19660101 MSH
EC congenital:Congenital Hypothyroidism MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EXTERNALLY_DEFINED N LNC
FX D003409 MSH
FX D009230 MSH
IAN DEFAULT ICD10
ICE Hypothyroidism, primary or NOS; Myxedema, primary or NOS ICD9CM
INCLUSION_TERM Myxoedema NOS ICD10
MDA 19990101 MSH
MESH_DEFINITION A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. NDFRT
MESH_DUI D007037 NDFRT
MESH_NAME Hypothyroidism NDFRT
MESH_UI M0010948 NDFRT
MMR 20160120 MSH
MN C19.874.482 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/hypothyroidism.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/hypothyroidism.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Institute of Diabetes and Digestive and Kidney Diseases http://www.niddk.nih.gov/ MEDLINEPLUS
NCI_THESAURUS_CODE C26800 PDQ
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Hypothyroidism NCI
NUI N0000001654 NDFRT
ORDER_NO 03661 ICD10CM
ORIG_STY Secondary related condition PDQ
PRIMARY_PATH 10021114$10043741$10043739$10014698$Hypothyroidism$Thyroid hypofunction disorders$Thyroid gland disorders$Endocrine disorders MDR
PRIMARY_SOC 10014698 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
REF orcid.org/0000-0001-5208-3432 HPO
RXAUI 3174961 RXNORM
RXAUI 3174962 RXNORM
RXCUI 1023091 RXNORM
SID HP:0003222 HPO
SID HP:0008203 HPO
SMQ_TERM_ADDVERSION 12.0 MDR
SMQ_TERM_ADDVERSION 18.1 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 12.0 MDR
SMQ_TERM_LMVERSION 18.1 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 40930008 NDFRT
SNOMEDID DB-80400 SNOMEDCT_US
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS E03.9 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~E03.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS E03.9 | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF AGE AT ONSET OF CLINICAL FINDING BEFORE 29.0 DAYS CHOOSE P72.2 | DESCENDANTS NOT EXHAUSTIVELY MAPPED | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447639009 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 445518008 | Age at onset of clinical finding (observable entity) | < 29.0 days SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~OTHERWISE TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~E03.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~P72.2 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUDWI SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~DB-80400 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T000892529 MSH
TERMUI T000892530 MSH
TERMUI T021070 MSH
TH NLM (1966) MSH
TH NLM (2017) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0020676

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