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Hydrocortisone (CUI C0020268) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0020268

NCI Thesaurus Code: C555  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Hormone

Semantic Type: Pharmacologic Substance

NCIt Definition: A synthetic or semisynthetic analog of natural hydrocortisone hormone produced by the adrenal glands with primary glucocorticoid and minor mineralocorticoid effects. As a glucocorticoid receptor agonist, hydrocortisone promotes protein catabolism, gluconeogenesis, capillary wall stability, renal excretion of calcium, and suppresses immune and inflammatory responses. (NCI04)

PDQ Definition: A synthetic or semisynthetic analog of natural hydrocortisone hormone produced by the adrenal glands with primary glucocorticoid and minor mineralocorticoid effects. As a glucocorticoid receptor agonist, hydrocortisone promotes protein catabolism, gluconeogenesis, capillary wall stability, renal excretion of calcium, and suppresses immune and inflammatory responses. Check for active clinical trials using this agent. (NCI Thesaurus)

NCI-GLOSS Definition: A drug used to relieve the symptoms of certain hormone shortages and to suppress an immune response.

CSP Definition: main glucocorticoid secreted by the adrenal cortex; its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.

MSH Definition: The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.

Synonyms & Abbreviations: (see Synonym Details)
(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
(11beta)-11,17,21-Trihydroxypregn-4-ene-3,20-dione
10483
11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione
11beta-hydrocortisone
11β-hydrocortisone
17-hydroxycorticosterone
4-Pregnen-11beta,17alpha,21-triol-3,20-dione
50-23-7
Aeroseb-HC
Barseb HC
Barseb-HC
Cetacort
Compound F
Cort-Dome
Cortef
Cortenema
Cortifan
cortisol
Cortispray
Cortril
Dermacort
Domolene-HC
Domolene
Eldecort
Hautosone
HC - Hydrocortisone
HC
Heb-Cort
Hidrocortisona
Hydrocortisone (substance)
Hydrocortisone [Chemical/Ingredient]
hydrocortisone
Hydrocortisonum
Hydrocortone
Hytone
Komed HC
Komed-HC
Nutracort
Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-
Proctocort
Product containing hydrocortisone (medicinal product)
Product containing hydrocortisone
Rectoid
Therapeutic Hydrocortisone

External Source Codes: 
NCI Thesaurus Code C555 (see NCI Thesaurus info)
CAS Registry Number 50-23-7 (see NLM ChemIDplus info)
FDA UNII Code WI4X0X7BPJ
NSC Code 10482 (see NCI DTP info)
NSC Code 10483 (see NCI DTP info)
PDQ Closed Trial Search ID 39274
PDQ Open Trial Search ID 39274 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BI BL CF CH CL CS CT DF EC GE HI IM IP ME PD PH PK PO RE SD SE ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:17650 NCI
Chemical_Formula C21H30O5 NCI
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID fe4.. SNOMEDCT_US
CTV3ID XUY3p SNOMEDCT_US
DATE_LAST_MODIFIED 2007-02-06 PDQ
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0059-6967 CSP
DX 19600101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20030731 SNOMEDCT_US
FDA_UNII_CODE WI4X0X7BPJ DRUGBANK
FDA_UNII_CODE WI4X0X7BPJ NDFRT
HN /adv eff-pois-tox was HYDROCORTISONE TOXICOLOGY 1963-65 MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
LT TRD MSH
LT TRD MTH
LT TRD PDQ
MDA 19990101 MSH
MESH_DEFINITION The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. NDFRT
MESH_DUI D006854 NDFRT
MESH_NAME Hydrocortisone NDFRT
MESH_UI M0010707 NDFRT
MMR 20160531 MSH
MN D04.210.500.745.745.654.600 MSH
MN D06.472.040.585.353.476 MSH
MN D06.472.040.585.478.392 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NCI_THESAURUS_CODE C555 PDQ
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006460 NDFRT
NUI N0000146291 NDFRT
ORIG_STY Drug/agent PDQ
PA D000893 MSH
PID 1904 PDQ
PM /adverse effects /poisoning /toxicity were HYDROCORTISONE TOXICOLOGY 1963-65 MSH
RN 0 MSH
RN WI4X0X7BPJ MSH
RR 4068-92-2 ((9 beta,10 alpha,11 alpha)-isomer) MSH
RR 50-23-7 (Hydrocortisone) MSH
RR 566-35-8 ((11 alpha)-isomer) MSH
RR 60103-17-5 (cpd w/o stereochem designation) MSH
RXAUI 1136299 RXNORM
RXAUI 1136311 RXNORM
RXAUI 1136315 RXNORM
RXAUI 1136318 RXNORM
RXAUI 1136321 RXNORM
RXAUI 1136324 RXNORM
RXAUI 1136332 RXNORM
RXAUI 1136337 RXNORM
RXAUI 1136340 RXNORM
RXAUI 172269 RXNORM
RXAUI 1910174 RXNORM
RXAUI 2071457 RXNORM
RXAUI 2597203 RXNORM
RXAUI 2599413 RXNORM
RXAUI 2802981 RXNORM
RXAUI 3135932 RXNORM
RXAUI 3169770 RXNORM
RXAUI 3169771 RXNORM
RXAUI 3173775 RXNORM
RXAUI 3173776 RXNORM
RXAUI 3223229 RXNORM
RXCUI 202639 RXNORM
RXCUI 202641 RXNORM
RXCUI 202643 RXNORM
RXCUI 202644 RXNORM
RXCUI 202645 RXNORM
RXCUI 202647 RXNORM
RXCUI 202652 RXNORM
RXCUI 202653 RXNORM
RXCUI 202654 RXNORM
RXCUI 202655 RXNORM
RXCUI 5492 RXNORM
RXN_BN_CARDINALITY single RXNORM
RXN_OBSOLETED 03/27/2013 RXNORM
RXN_OBSOLETED 03/29/2016 RXNORM
RXN_OBSOLETED 09/30/2013 RXNORM
SID APRD01019 DRUGBANK
SID DB07886 DRUGBANK
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SPL_SET_ID fc29adaa-48f1-40d4-a721-307462f3025a MTHSPL
SPL_SET_ID fcd4747b-3c54-4b2f-a6bc-eafa0cf7016e MTHSPL
SPL_SET_ID fd6343a9-15a6-4894-b51f-122e4d6dbe79 MTHSPL
SPL_SET_ID fdcda809-9798-4370-bda0-310bb8bb9a59 MTHSPL
SPL_SET_ID fdf62f87-8b60-47ff-968a-0a5f0c8bc42f MTHSPL
SPL_SET_ID fe571543-26fd-4cae-8e6a-0b35d728b46d MTHSPL
SPL_SET_ID fe5ec664-6cec-4944-b7cb-a25d2da0a303 MTHSPL
SPL_SET_ID fe749381-e4d1-47ef-908e-3b24c9d91385 MTHSPL
SPL_SET_ID fecf8380-3bb5-11e5-98c5-0002a5d5c51b MTHSPL
SPL_SET_ID fefdf8fc-1664-4961-a074-ed94591f62df MTHSPL
SPL_SET_ID ff34da77-5e96-4ed1-8c28-ba0b2f35576a MTHSPL
SPL_SET_ID ffd1edc1-2f40-4b0a-a53a-9fb53b8d3184 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~fe4.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUY3p SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T020678 MSH
TERMUI T020679 MSH
TERMUI T020683 MSH
TH BAN (19XX) MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH UNK (19XX) MSH
TH USP (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^536^Active/Master NDFRT
VANDF_RECORD 50.6^286^Active/Master NDFRT
VUID 4017941 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0020268

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