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Histamine (CUI C0019588) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0019588

NCI Thesaurus Code: C73238  (see NCI Thesaurus info)

Semantic Type: Biologically Active Substance

Semantic Type: Organic Chemical

NCI-GLOSS Definition: A substance that has many effects in the body. It is released from some types of white blood cells during allergic reactions. It causes small blood vessels to dilate (widen) and become leaky, which can cause tissues to swell. It also causes smooth muscles to contract, gastric acid to be made, and the heart rate to increase. Histamine is used in tests for allergies, asthma, and gastric acid secretion. It is a type of neurotransmitter.

CSP Definition: depressor amine derived by enzymatic decarboxylation of histidine, present in the secretory granules of mast cells; a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.

MSH Definition: An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.

Synonyms & Abbreviations: (see Synonym Details)
1H-Imidazole-4-ethanamine
2-(4-Imidazolyl)ethylamine
4-(2-Aminoethyl)-1H-imidazole
5-Imidazoleethylamine
Histamine (substance)
Histamine [Chemical/Ingredient]
histamine

External Source Codes: 
NCI Thesaurus Code C73238 (see NCI Thesaurus info)
CAS Registry Number 51-45-6 (see NLM ChemIDplus info)
FDA UNII Code 820484N8I3
NSC Code 33792 (see NCI DTP info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AN BI BL CF CH CL CS CT DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UR MSH
AUTHORITY Gray's 99:1900-11901 Table 15.1 FMA
AUTHORITY Gray's 99:936; Burt 93:105 FMA
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:18295 NCI
Chemical_Formula C5H9N3 NCI
Contributing_Source FDA NCI
CTV3ID X795m SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 1549-4121 CSP
DX 19600101 MSH
EC agonists:Histamine Agonists MSH
EC antagonists & inhibitors:Histamine Antagonists MSH
EC secretion:Histamine Release MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
FDA_UNII_CODE 820484N8I3 DRUGBANK
FDA_UNII_CODE 820484N8I3 NDFRT
FX D006969 MSH
FX D011968 MSH
HN /antagonists & inhibitors was ANTIHISTAMINICS 1963-76 MSH
LEVEL Ingredient NDFRT
MDA 19990101 MSH
MESH_DEFINITION An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter. NDFRT
MESH_DUI D006632 NDFRT
MESH_NAME Histamine NDFRT
MESH_UI M0010390 NDFRT
MMR 20160531 MSH
MN D02.092.211.215.501 MSH
MN D02.092.471.440 MSH
MN D03.383.129.308.373 MSH
MN D23.469.050.300 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006292 NDFRT
NUI N0000147867 NDFRT
OL search HISTAMINE /antagonists & inhibitors under HISTAMINE H1 RECEPTOR BLOCKADERS 1966-76 MSH
PA D017442 MSH
PM /antagonists & inhibitors was ANTIHISTAMINICS 1963-76 MSH
RN 820484N8I3 MSH
RR 3POA0Q644U MSH
RR 51-45-6 (Histamine) MSH
RXAUI 167425 RXNORM
RXAUI 2071355 RXNORM
RXAUI 3052143 RXNORM
RXAUI 3091907 RXNORM
RXAUI 3168494 RXNORM
RXAUI 3168495 RXNORM
RXAUI 3173024 RXNORM
RXAUI 3173052 RXNORM
RXAUI 4618296 RXNORM
RXAUI 5027843 RXNORM
RXCUI 5333 RXNORM
SNOMEDID F-CB050 SNOMEDCT_US
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SPL_SET_ID fd42f96d-2985-4ec7-860a-0eda2c4cc297 MTHSPL
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SPL_SET_ID fe5db88c-8b7e-b090-096b-668f6fee44ba MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~X795m SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~F-CB050 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
TERMUI T019963 MSH
TH FDA SRS (2014) MSH
TH NLM (1966) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
UWT Anatomical Structure UWDA
VANDF_RECORD 50.416^2399^Active/Master NDFRT
VANDF_RECORD 50.6^36^Active/Master NDFRT
VUID 4019776 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0019588

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