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Hepatic Encephalopathy (CUI C0019151) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0019151

NCI Thesaurus Code: C79596  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: A constellation of signs and symptoms characterized by changes in personality, consciousness, and reflexes, resulting from neuropsychiatric abnormalities secondary to liver failure without evidence of other brain disease.

GARD Definition: Hepatic encephalopathy is a syndrome observed in some patients with cirrhosis. It is defined as a spectrum of neuropsychiatric abnormalities in patients with liver dysfunction, when other known brain disease has been excluded.  Signs and symptoms may be debilitating, and they can begin mildly and gradually, or occur suddenly and severely. They may include personality or mood changes, intellectual impairment, abnormal movements, a depressed level of consciousness, and other symptoms.  There are several theories regarding the exact cause, but development of the condition is probably at least partially due to the effect of substances that are toxic to nerve tissue (neurotoxic), which are typically present with liver damage and/or liver disease. Treatment depends upon the severity of mental status changes and upon the certainty of the diagnosis. - this information is from GARD/ORDR/NCATS.

HPO Definition: Central nervous system dysfunction in association with liver failure and characterized clinically (depending on degree of severity) by lethargy, confusion, nystagmus, decorticate posturing, spasticity, and bilateral Babinski reflexes. [HPO:probinson]

CSP Definition: syndrome characterized by central nervous system dysfunction in association with liver failure, including portal-systemic shunts; clinical features include lethargy and confusion, frequently progressing to coma, asterixis, nystagmus, brisk oculovestibular reflexes, decorticate and decerebrate posturing, muscle spasticity, and bilateral extensor plantar reflexes.

MSH Definition: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)

Synonyms & Abbreviations: (see Synonym Details)
coma hepaticum
ENCEPH HEPATIC
ENCEPH HEPATOCEREBRAL
ENCEPH PORTAL SYSTEMIC
ENCEPH PORTOSYSTEMIC
Encephalopathies, Hepatic
Encephalopathies, Hepatocerebral
Encephalopathies, Portal-Systemic
Encephalopathies, Portosystemic
ENCEPHALOPATHY HEPATIC
ENCEPHALOPATHY, HEPATIC
Encephalopathy, Hepatocerebral
Encephalopathy, Portal Systemic
ENCEPHALOPATHY, PORTAL-SYSTEMIC
Encephalopathy, Portosystemic
Gaustad syndrome
Gaustad's syndrome
HE - Hepatic encephalopathy
hepatic coma/encephalopathy
Hepatic Encephalopathies
Hepatic encephalopathy (disorder)
Hepatic Encephalopathy [Disease/Finding]
hepatic encephalopathy
HEPATIC ENCEPH
Hepatocerebral Encephalopathies
Hepatocerebral Encephalopathy
HEPATOCEREBRAL ENCEPH
hepatocerebral syndrome
Hepatoencephalopathy
portacaval encephalopathy
Portal systemic encephalopathy (disorder)
Portal Systemic Encephalopathy
PORTAL SYSTEMIC ENCEPH
Portal-Systemic Encephalopathies
portal-systemic encephalopathy
Portosystemic Encephalopathies
Portosystemic Encephalopathy
PORTOSYSTEMIC ENCEPH
Transient hepatargy syndrome

External Source Codes: 
NCI Thesaurus Code C79596 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CTV3ID X0058 SNOMEDCT_US
CTV3ID XUl9E SNOMEDCT_US
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 1754-6730 CSP
DISEASE_IDENTIFIER_ID 1674 GARD
DISEASE_IDENTIFIER_ID 1675 GARD
DX 19840101 MSH
EFFECTIVE_TIME 20040731 SNOMEDCT_US
EFFECTIVE_TIME 20120131 SNOMEDCT_US
HAS_GARD_PAGE true GARD
HN 1984; use HEPATIC COMA 1975-83 MSH
ICE Hepatic coma; Hepatocerebral intoxication; Portal-systemic encephalopathy ICD9CM
IDENTIFIER_TYPE_ID 1 GARD
IS_ACTIVE true GARD
IS_RARE true GARD
IS_SPANISH false GARD
MDA 19990101 MSH
MESH_DEFINITION A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5) NDFRT
MESH_DUI D006501 NDFRT
MESH_NAME Hepatic Encephalopathy NDFRT
MESH_UI M0010200 NDFRT
MMR 20060705 MSH
MN C06.552.308.500.356 MSH
MN C10.228.140.163.360 MSH
MN C18.452.132.360 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DISEASE_KIND NDFRT
NUI N0000001496 NDFRT
PM 1984; see HEPATIC COMA 1975-83; HEPATIC COMA was heading 1963-83 MSH
PRIMARY_PATH 10019660$10014624$10014623$10029205$Hepatic encephalopathy$Encephalopathies toxic and metabolic$Encephalopathies$Nervous system disorders MDR
PRIMARY_SOC 10029205 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/10452/hepatic-encephalopathy/resources/1 GARD
RXAUI 3153876 RXNORM
RXAUI 3153877 RXNORM
RXAUI 3153893 RXNORM
RXAUI 3153894 RXNORM
RXAUI 3172148 RXNORM
RXAUI 3172149 RXNORM
RXAUI 3172309 RXNORM
RXAUI 3222580 RXNORM
RXAUI 3222582 RXNORM
RXCUI 1024215 RXNORM
SMQ_TERM_ADDVERSION 10.1 MDR
SMQ_TERM_ADDVERSION 19.0 MDR
SMQ_TERM_ADDVERSION 8.0 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_CAT B MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 10.1 MDR
SMQ_TERM_LMVERSION 12.1 MDR
SMQ_TERM_LMVERSION 19.0 MDR
SMQ_TERM_SCOPE 1 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 13920009 NDFRT
SOS A progressive metabolic liver disorder that affects intellectual functioning and is characterized by disturbances of consciousness that may progress to psychiatric changes or coma. AOD
SOS Excludes: hepatic coma associated with viral hepatitis - see category 070 ICD9CM
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS K72.9 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~K72.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS K72.90 | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS K72.90 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~K72.90 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~X0058 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUl9E SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T019603 MSH
TERMUI T019604 MSH
TERMUI T368462 MSH
TERMUI T368463 MSH
TERMUI T368464 MSH
TERMUI T368465 MSH
TERMUI T368466 MSH
TERMUI T368467 MSH
TH NLM (1966) MSH
TH NLM (1990) MSH
TH NLM (2000) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0019151

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